Compile Data Set for Download or QSAR
Report error Found 474 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 2 subunit alpha'
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118519(CHEMBL3617050)
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of NaV1.2 channel (unknown origin) expressed in Xenopus laevis oocytes by two-electrode oocyte voltage-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118514(US9481677, 38 | CHEMBL3617063)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of full length human Nav1.2 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233223(CHEMBL4060338)
Affinity DataIC50: 0.280nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced tail current by whole cell patch clamp method re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233223(CHEMBL4060338)
Affinity DataIC50: 0.450nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced sustained current by whole cell patch clamp meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50: 1nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233224(CHEMBL4070670)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced tail current by whole cell patch clamp method re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50: 2nMAssay Description:Inhibition of human Nav1.2 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -35 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50: 2nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233224(CHEMBL4070670)
Affinity DataIC50: 2.10nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced sustained current by whole cell patch clamp meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human Nav1.2 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051090(CHEMBL3318149)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50: 3nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051091(CHEMBL3318150)
Affinity DataIC50: 3nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50242400(CCNCSSKWCRDHSRCC | CHEMBL525818)
Affinity DataKd:  3nMAssay Description:Inhibition of rat Nav1.2 channel expressed in Xenopus oocytes by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051089(CHEMBL3318148)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169425(US9481677, 44 | CHEMBL3341983)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of full length human Nav1.2 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233221(CHEMBL4064160)
Affinity DataEC50:  5.30nMAssay Description:Inhibition of Nav1.2 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50492340(CHEMBL2402969)
Affinity DataKd:  5.30nMAssay Description:Binding affinity to rat voltage-gated sodium channel Nav1.2 expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM145466(US8952169, 245)
Affinity DataIC50: 6nMAssay Description:Inhibition of human Nav1.2 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -35 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM268418(N-(7-(adamantan-1-ylmethoxy)-6-ethyl-[1,2,4]triazo...)
Affinity DataIC50: 7nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.2 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233222(CHEMBL4082248)
Affinity DataIC50: 7.5nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced sustained current by whole cell patch clamp meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051075(CHEMBL3318134)
Affinity DataIC50: 8nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051088(CHEMBL3318147)
Affinity DataIC50: 8nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50030510([1-Benzyl-7-chloro-1H-quinolin-(4E)-ylidene]-penty...)
Affinity DataKi:  9nMAssay Description:Inhibition of rat brain voltage-gated sodium channel subunit alpha Nav1.2-mediated current expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM268527(US9550775, 106 | N-(6-cyclopropyl-7-((3,5-dichloro...)
Affinity DataIC50: 10nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.2 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 12nMAssay Description:Inhibition of human Nav1.2 by V1/2 protocol based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50521571(CHEMBL4464990)
Affinity DataKd:  12nMAssay Description:Inhibition of full length human Nav1.2 expressed in HEK293 cells at -60 mV holding potential by manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233223(CHEMBL4060338)
Affinity DataEC50:  12nMAssay Description:Inhibition of Nav1.2 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM268423(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...)
Affinity DataIC50: 14nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.2 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50: 14nMAssay Description:Inhibition of Na+ influx in chinese hamster ovary cells expressing rat brain sodium channel type IIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50: 19nMAssay Description:Inhibition of full length human Nav1.2 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50: 20nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051077(CHEMBL3318136)
Affinity DataIC50: 24nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50582059(CHEMBL5082582)
Affinity DataEC50:  24nMAssay Description:Modulator activity at rat Nav1.2 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233221(CHEMBL4064160)
Affinity DataIC50: 26nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced sustained current by whole cell patch clamp meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051084(CHEMBL3318143)
Affinity DataIC50: 28nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50242509(CHEMBL4068937)
Affinity DataIC50: 29nMAssay Description:Inhibition of Nav1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2019
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50: 30nMAssay Description:Inhibition of voltage-gated Na channel 1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051079(CHEMBL3318138)
Affinity DataIC50: 33nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233222(CHEMBL4082248)
Affinity DataIC50: 35nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced tail current by whole cell patch clamp method re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50118517(CHEMBL3617067)
Affinity DataIC50: 36nMAssay Description:Inhibition of rat NaV1.2 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 38nMAssay Description:Inhibition of full length human Nav1.2 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50051073(CHEMBL3318132)
Affinity DataIC50: 41nMAssay Description:Inhibition of Nav1.2 (unknown origin) expressed in xenopus oocytes at -80 mV holding potential by two-electrode voltage-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051076(CHEMBL3318135)
Affinity DataIC50: 45nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051082(CHEMBL3318141)
Affinity DataIC50: 45nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50262566((2S,3S)-3-[(1R)-6-Methoxy-1-methyl-1-trifluorometh...)
Affinity DataIC50: 48nMAssay Description:Displacement of [3H]batrachotoxinin from rat sodium channel type 2A subunit expressed in CHO-CNa2A cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051081(CHEMBL3318140)
Affinity DataIC50: 50nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50582060(CHEMBL5084333)
Affinity DataEC50:  50nMAssay Description:Modulator activity at rat Nav1.2 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
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