Report error Found 465 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 2 subunit alpha'
Affinity DataKd: 3nMAssay Description:Inhibition of rat Nav1.2 channel expressed in Xenopus oocytes by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataEC50: 7.90E+3nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataEC50: 5.30nMAssay Description:Inhibition of Nav1.2 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataEC50: 79nMAssay Description:Inhibition of Nav1.2 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataEC50: 120nMAssay Description:Inhibition of Nav1.2 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataEC50: 12nMAssay Description:Inhibition of Nav1.2 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKd: 64nMAssay Description:Binding affinity to human recombinant Nav1.2 by radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKd: 140nMAssay Description:Binding affinity to human recombinant Nav1.2 by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 400nMAssay Description:Binding affinity to rat voltage-gated sodium channel Nav1.2 expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataKd: 1.00E+3nMAssay Description:Binding affinity to rat voltage-gated sodium channel Nav1.2 expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataKd: 55nMAssay Description:Binding affinity to rat voltage-gated sodium channel Nav1.2 expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataKd: 5.30nMAssay Description:Binding affinity to rat voltage-gated sodium channel Nav1.2 expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataKd: 1.40E+3nMAssay Description:Binding affinity to rat voltage-gated sodium channel Nav1.2 expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataKd: 290nMAssay Description:Binding affinity to rat voltage-gated sodium channel Nav1.2 expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataKd: 500nMAssay Description:Binding affinity to rat voltage-gated sodium channel Nav1.2 expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKd: 12nMAssay Description:Inhibition of full length human Nav1.2 expressed in HEK293 cells at -60 mV holding potential by manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataEC50: 360nMAssay Description:Modulator activity at rat Nav1.2 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataEC50: 98nMAssay Description:Modulator activity at rat Nav1.2 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataEC50: 138nMAssay Description:Modulator activity at rat Nav1.2 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataEC50: 134nMAssay Description:Modulator activity at rat Nav1.2 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataEC50: 156nMAssay Description:Modulator activity at rat Nav1.2 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Modulator activity at rat Nav1.2 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Modulator activity at rat Nav1.2 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of NaV1.2 channel (unknown origin) expressed in Xenopus laevis oocytes by two-electrode oocyte voltage-clamp methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 0.200nMAssay Description:Inhibition of full length human Nav1.2 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 0.280nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced tail current by whole cell patch clamp method re...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 0.450nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced sustained current by whole cell patch clamp meth...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 1nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced tail current by whole cell patch clamp method re...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 2nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 2nMAssay Description:Inhibition of human Nav1.2 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -35 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 2.10nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced sustained current by whole cell patch clamp meth...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human Nav1.2 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 3nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 4.20nMAssay Description:Inhibition of full length human Nav1.2 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 6nMAssay Description:Inhibition of human Nav1.2 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -35 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 7nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.2 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 7.5nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced sustained current by whole cell patch clamp meth...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 10nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.2 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 12nMAssay Description:Inhibition of human Nav1.2 by V1/2 protocol based analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of Na+ influx in chinese hamster ovary cells expressing rat brain sodium channel type IIAMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 14nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.2 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 14nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Human)
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 19nMAssay Description:Inhibition of full length human Nav1.2 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
