Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with Target = 'Sodium/hydrogen exchanger 2'
TargetSodium/hydrogen exchanger 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104844(N-[(1R,3R)-3-(2,3-Dihydro-benzofuran-4-yl)-2,2-dim...)
Affinity DataIC50: 1.80E+3nMAssay Description:Compound is screened in AP1 cells expressing human NHE-2 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50097897(N-(5-Methyl-1-phenyl-1H-pyrazole-4-carbonyl)-guani...)
Affinity DataIC50: 3.90E+3nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191831(5-(4-fluoro-3-methylphenyl)-2-methoxy-4-(4-(4-meth...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human NHE2 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50058715(CHEMBL64360 | EMD-96785 | N-(diaminomethylene)-2-m...)
Affinity DataIC50: 9.20E+3nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50097898(N-(5-Cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-car...)
Affinity DataIC50: 1.20E+4nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50097895(N-(5-Cyclopropyl-1-phenyl-1H-pyrazole-4-carbonyl)-...)
Affinity DataIC50: 1.28E+4nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50097896(N-(5-Cyclopropyl-1-naphthalen-1-yl-1H-pyrazole-4-c...)
Affinity DataIC50: 1.63E+4nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50058715(CHEMBL64360 | EMD-96785 | N-(diaminomethylene)-2-m...)
Affinity DataIC50: 1.70E+4nMAssay Description:Compound is screened in AP1 cells expressing human NHE-2 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50058715(CHEMBL64360 | EMD-96785 | N-(diaminomethylene)-2-m...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human NHE2 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50058759(CHEMBL436559 | N-(diaminomethylene)-4-isopropyl-3-...)
Affinity DataIC50: 2.87E+4nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50058759(CHEMBL436559 | N-(diaminomethylene)-4-isopropyl-3-...)
Affinity DataIC50: 6.20E+4nMAssay Description:Compound is screened in AP1 cells expressing human NHE-2 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50058759(CHEMBL436559 | N-(diaminomethylene)-4-isopropyl-3-...)
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of human NHE2 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50196789(CHEMBL3892788)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human NHE2 expressed in LAP1 cell assessed as intracellular pH recovery measured for 2 mins by CECF-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50097899(N-(5-Methyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl...)
Affinity DataIC50: 4.16E+5nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In DepthDetails Article
PubMed