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Report error Found 81 Enz. Inhib. hit(s) with Target = 'Small conductance calcium-activated potassium channel protein 2'
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583211(CHEMBL5078247)
Affinity DataEC50:  990nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583197(CHEMBL5079951)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583198(CHEMBL5090455)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583199(CHEMBL5074647)
Affinity DataEC50:  4.97E+4nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583200(CHEMBL5093708)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583201(CHEMBL5080805)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50275157(N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-me...)
Affinity DataEC50:  7.48E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583202(CHEMBL5083279)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583203(CHEMBL5081876)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583204(CHEMBL5075501)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583205(CHEMBL5069418)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583206(CHEMBL5079218)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583207(CHEMBL5088689)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583208(CHEMBL5089976)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583209(CHEMBL5082158)
Affinity DataEC50:  5.03E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583210(CHEMBL5074700)
Affinity DataEC50:  1.89E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583196(CHEMBL5084004)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583212(CHEMBL5076878)
Affinity DataEC50:  1.99E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583213(CHEMBL5086997)
Affinity DataEC50:  640nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583214(CHEMBL5076032)
Affinity DataEC50:  2.97E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583215(CHEMBL5075016)
Affinity DataEC50:  3.45E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583216(CHEMBL5081906)
Affinity DataEC50:  3.27E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583217(CHEMBL5084258)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583218(CHEMBL5090801)
Affinity DataEC50: >3.00E+4nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583219(CHEMBL5088936)
Affinity DataEC50:  6.59E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583220(CHEMBL5079766)
Affinity DataEC50:  4.51E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583221(CHEMBL5088498)
Affinity DataEC50:  3.88E+4nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583222(CHEMBL5094693)
Affinity DataEC50:  1.38E+4nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583223(CHEMBL5077913)
Affinity DataEC50:  3.59E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583224(CHEMBL5090420)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583225(CHEMBL5076140)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583226(CHEMBL5086120)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275183(1-ethyl-1H-benzo[d]imidazol-2(3H)-one | CHEMBL4528...)
Affinity DataEC50:  7.22E+5nMAssay Description:Positive modulation of SK2 in HEK293 cells in presence of Ca2+ by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275157(N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-me...)
Affinity DataEC50:  1.40E+4nMAssay Description:Positive modulation of SK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50618500(CHEMBL5421015)
Affinity DataEC50:  1.80E+3nMAssay Description:Positive modulation of SK2 in HEK293 cells in presence of Ca2+ by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275184(6,7-dichloro-3-(hydroxyimino)indolin-2-one | CHEMB...)
Affinity DataEC50:  800nMAssay Description:Positive modulation of SK2 in HEK293 cells in presence of Ca2+ by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583211(CHEMBL5078247)
Affinity DataEC50:  110nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells assessed as increase in calcium response at -90 mV holding potential measured at 1 to 2 days by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583213(CHEMBL5086997)
Affinity DataEC50:  91nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells assessed as increase in calcium response at -90 mV holding potential measured at 1 to 2 days by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583231(CHEMBL5094656)
Affinity DataEC50:  4.32E+3nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583230(CHEMBL5075803)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583229(CHEMBL5088379)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275090((1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetr...)
Affinity DataKd:  47nMAssay Description:Inhibition of human SK2 channel by inside-out patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583228(CHEMBL5072517)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50561185(CHEMBL4749661)
Affinity DataEC50:  0.0270nMAssay Description:Inhibition of recombinant rat SK2 expressed in HEK293 cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataEC50:  1.40E+4nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50583227(CHEMBL5079837)
Affinity DataEC50: >1.00E+5nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50561184(CHEMBL4762592)
Affinity DataEC50:  0.290nMAssay Description:Inhibition of recombinant rat SK2 expressed in HEK293 cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Chapman University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50561183(CHEMBL4787693)
Affinity DataEC50:  0.0240nMAssay Description:Inhibition of recombinant rat SK2 expressed in HEK293 cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50263327(N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2...)
Affinity DataIC50: 11nMAssay Description:Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50263327(N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2...)
Affinity DataIC50: 59nMAssay Description:Displacement of [125I]apamin from Kca2.2 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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