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Report error Found 103 Enz. Inhib. hit(s) with Target = 'Signal transducer and activator of transcription 5B' Sort by
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50033887(CHEMBL3358611)
Affinity DataKd:  42nMAssay Description:Binding affinity to full-length His-tagged STAT5B (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50303041((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-5-(5-...)
Affinity DataEC50:  40nMAssay Description:Inhibition of erythropoietin-stimulated STAT5 expressed in human U2OS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50303042((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-6-met...)
Affinity DataEC50:  40nMAssay Description:Inhibition of erythropoietin-stimulated STAT5 expressed in human U2OS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataEC50:  20nMAssay Description:Inhibition of erythropoietin-stimulated STAT5 expressed in human U2OS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50557878(CHEMBL4776801)
Affinity DataKd: >10nMAssay Description:Binding affinity to human recombinant STAT5B assessed as dissociation constant incubated for 15 mins by biolayer interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50267892(CHEMBL4088092)
Affinity DataIC50: 154nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50267888(CHEMBL4104462)
Affinity DataIC50: 220nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50267877(CHEMBL4103576)
Affinity DataIC50: 234nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50267890(CHEMBL4085646)
Affinity DataIC50: 240nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50267878(CHEMBL4104019)
Affinity DataIC50: 260nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50267889(CHEMBL4080219)
Affinity DataIC50: 270nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50267885(CHEMBL4066274)
Affinity DataIC50: 280nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50267884(CHEMBL4086096)
Affinity DataIC50: 290nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50267887(CHEMBL4077592)
Affinity DataIC50: 330nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50267886(CHEMBL4093849)
Affinity DataIC50: 350nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50267876(CHEMBL4080740)
Affinity DataIC50: 390nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50267862(CHEMBL4075745)
Affinity DataIC50: 460nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50267875(CHEMBL4062751)
Affinity DataIC50: 620nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50267891(CHEMBL4076474)
Affinity DataIC50: 660nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50514407(CHEMBL4483038)
Affinity DataIC50: 1.40E+3nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50240455(CHEMBL1253351)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of 5-carboxyfluorescein-GpYLVLDKW-OH binding to STAT5B SH2 domain (unknown origin) pre-incubated for 1 hr before fluorescent-labelled pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50514413(CHEMBL4555061)
Affinity DataIC50: 2.90E+3nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50000029(suramin | SURAMIN HEXASODIUM | CHEMBL265502 | 4-Me...)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of 5-carboxyfluorescein-GpYLVLDKW-OH binding to STAT5B SH2 domain (unknown origin) pre-incubated for 1 hr before fluorescent-labelled pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50118228(5,7-Disulfo-4-(3-{3-[3-(4,6,8-trisulfo-naphthalen-...)
Affinity DataIC50: 1.27E+4nMAssay Description:Inhibition of 5-carboxyfluorescein-GpYLVLDKW-OH binding to STAT5B SH2 domain (unknown origin) pre-incubated for 1 hr before fluorescent-labelled pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2020
Entry Details Article
PubMed
LigandPNGBDBM50514414(CHEMBL4439829)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of STAT5b in mouse BaF3/FLT3-ITD cells assessed as reduction in cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50514414(CHEMBL4439829)
Affinity DataIC50: 3.70E+4nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50514413(CHEMBL4555061)
Affinity DataIC50: 7.60E+4nMAssay Description:Inhibition of STAT5b in mouse BaF3/FLT3-ITD cells assessed as reduction in cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50514407(CHEMBL4483038)
Affinity DataIC50: 1.53E+5nMAssay Description:Inhibition of STAT5b in mouse BaF3/FLT3-ITD cells assessed as reduction in cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50033887(CHEMBL3358611)
Affinity DataKi:  146nMAssay Description:Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM165192(4-((8-Methylnonanamido)methyl)-1,2-phenylene bis(d...)
Affinity DataKi:  340nM IC50: 750nMAssay Description:For competition-based fluorescence polarization assays, the ability of the test compounds to displace fluorophore-labeled peptides from their respect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2016
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM165193(4-(Nonanamidomethyl)-1,2-phenylene bis(dihydrogen ...)
Affinity DataKi:  390nM IC50: 860nMAssay Description:For competition-based fluorescence polarization assays, the ability of the test compounds to displace fluorophore-labeled peptides from their respect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2016
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50632189(CHEMBL5395962)
Affinity DataKi:  400nMAssay Description:Binding affinity to STAT5B (unknown origin) assessed as inhibition constant by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50514409(CHEMBL4549938)
Affinity DataKi:  600nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50632188(CHEMBL5428281)
Affinity DataKi:  800nMAssay Description:Binding affinity to STAT5B (unknown origin) assessed as inhibition constant by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50632187(CHEMBL5403493)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to STAT5B (unknown origin) assessed as inhibition constant by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50632178(CHEMBL5402407)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to STAT5B (unknown origin) assessed as inhibition constant by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50632180(CHEMBL5438554)
Affinity DataKi:  1.30E+3nMAssay Description:Binding affinity to STAT5B (unknown origin) assessed as inhibition constant by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50632184(CHEMBL5416509)
Affinity DataKi:  1.60E+3nMAssay Description:Binding affinity to STAT5B (unknown origin) assessed as inhibition constant by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50632186(CHEMBL5398037)
Affinity DataKi:  1.60E+3nMAssay Description:Binding affinity to STAT5B (unknown origin) assessed as inhibition constant by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50632183(CHEMBL5395896)
Affinity DataKi:  1.70E+3nMAssay Description:Binding affinity to STAT5B (unknown origin) assessed as inhibition constant by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50632179(CHEMBL5396273)
Affinity DataKi:  2.00E+3nMAssay Description:Binding affinity to STAT5B (unknown origin) assessed as inhibition constant by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50632174(CHEMBL5430356)
Affinity DataKi:  2.10E+3nMAssay Description:Binding affinity to STAT5B (unknown origin) assessed as inhibition constant by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50632185(CHEMBL5419146)
Affinity DataKi:  2.50E+3nMAssay Description:Binding affinity to STAT5B (unknown origin) assessed as inhibition constant by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50353445(CHEMBL1829862 | US10196373, Compound 45B)
Affinity DataKi:  2.80E+3nMAssay Description:Displacement of 5-carboxyfluorescein-labeled GpYLVLDKW from the STAT5b-SH2 domain after 15 mins by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50632181(CHEMBL5395196)
Affinity DataKi:  3.10E+3nMAssay Description:Binding affinity to STAT5B (unknown origin) assessed as inhibition constant by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50382463(CHEMBL2023989)
Affinity DataKi:  3.40E+3nMAssay Description:Displacement of 5-carboxyfluorescein-labeled GpYLVLDKW from the STAT5b-SH2 domain after 15 mins by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50382460(CHEMBL2023985 | US10196373, Compound 27NA)
Affinity DataKi:  3.80E+3nMAssay Description:Displacement of 5-carboxyfluorescein-labeled GpYLVLDKW from the STAT5b-SH2 domain after 15 mins by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50632182(CHEMBL5419471)
Affinity DataKi:  4.00E+3nMAssay Description:Binding affinity to STAT5B (unknown origin) assessed as inhibition constant by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50353444(CHEMBL1829870 | US10196373, Compound 45C)
Affinity DataKi:  4.10E+3nMAssay Description:Displacement of 5-carboxyfluorescein-labeled GpYLVLDKW from the STAT5b-SH2 domain after 15 mins by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50632173(CHEMBL5398612)
Affinity DataKi:  4.20E+3nMAssay Description:Binding affinity to STAT5B (unknown origin) assessed as inhibition constant by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
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