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Report error Found 3872 Enz. Inhib. hit(s) with Target = 'Serine protease 1'
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50003740(CHEMBL134926 | amino{[4-(2-methylene-6-oxotetrahyd...)
Affinity DataKon:  0.0000330M-1s-1Assay Description:Decylation rate constant against trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50230149(CHEMBL1161040)
Affinity DataKon:  0.000333M-1s-1Assay Description:Decylation rate constant against trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50003739(CHEMBL134927 | (Lactone3)N-[4-(4-Guanidino-phenyl)...)
Affinity DataKon:  0.000250M-1s-1Assay Description:Compound was tested for the rate constant of deacylation against the enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50003741(CHEMBL137269 | N-[4-(2-Iodomethylene-6-oxo-tetrahy...)
Affinity DataKon:  0.000330M-1s-1Assay Description:Compound was tested for the rate constant of deacylation against the enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50003740(CHEMBL134926 | amino{[4-(2-methylene-6-oxotetrahyd...)
Affinity DataKon:  0.0000330M-1s-1Assay Description:Compound was tested for the rate constant of deacylation against the enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Human)TBA
LigandPNGBDBM50212459(CHEMBL1159958)
Affinity DataKon:  0.0000330M-1s-1Assay Description:Rate constant of deacylation for trypsinMore data for this Ligand-Target Pair
In DepthDetails

TargetSerine protease 1(Human)TBA
LigandPNGBDBM50212461(CHEMBL1159957)
Affinity DataKon:  0.000333M-1s-1Assay Description:Rate constant of deacylation for trypsinMore data for this Ligand-Target Pair
In DepthDetails

TargetSerine protease 1(Human)TBA
LigandPNGBDBM50212463(CHEMBL1159918)
Affinity DataKon:  0.0000250M-1s-1Assay Description:Rate constant of deacylation for trypsin; Fast and could not be measuredMore data for this Ligand-Target Pair
In DepthDetails

TargetSerine protease 1(Human)TBA
LigandPNGBDBM50212460(CHEMBL1159951)
Affinity DataKon:  0.0000830M-1s-1Assay Description:Rate constant of deacylation for trypsinMore data for this Ligand-Target Pair
In DepthDetails

TargetSerine protease 1(Human)TBA
LigandPNGBDBM50473778(CHEMBL92820)
Affinity DataKd:  347nMAssay Description:Binding affinity against trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Human)TBA
LigandPNGBDBM50113835(Integrase inhibitor, R1{2} | CHEMBL12392 | 4-fluor...)
Affinity DataKd:  4.27E+5nMAssay Description:Binding affinity against trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Human)TBA
LigandPNGBDBM10758(14C-phenylethylamine | 2-phenylethan-1-amine | CHE...)
Affinity DataKd:  1.10E+7nMAssay Description:Binding affinity against trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Human)TBA
LigandPNGBDBM50113829(Decarboxylated derivative | C-Cyclohexyl-methylami...)
Affinity DataKd:  1.15E+6nMAssay Description:Binding affinity against trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Human)TBA
LigandPNGBDBM50113840(4-Phenyl-butylamine | 4-phenylbutylamine | CHEMBL7...)
Affinity DataKd:  2.00E+7nMAssay Description:Binding affinity against trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Human)TBA
LigandPNGBDBM50038002(Benzamidine (Protonated) | CHEMBL537204 | CHEMBL20...)
Affinity DataKd:  1.82E+4nMAssay Description:Binding affinity against trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Human)TBA
LigandPNGBDBM50113826(3-phenylpropylamine | 3-Phenyl-propylamine | CHEMB...)
Affinity DataKd:  3.24E+7nMAssay Description:Binding affinity against trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Human)TBA
LigandPNGBDBM50236898((1S,2R)-(+)-2-phenylcyclopropylamine | trans-2-phe...)
Affinity DataKd:  1.32E+7nMAssay Description:Binding affinity against trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50511166(CHEMBL4513436)
Affinity DataKd:  43nMAssay Description:Binding affinity to bovine beta-trypsin in phosphate/HEPES/Tricine/Tris buffer by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50511169(CHEMBL4551377)
Affinity DataKd:  68nMAssay Description:Binding affinity to bovine beta-trypsin in phosphate/HEPES/Tricine/Tris buffer by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50511168(CHEMBL4465587)
Affinity DataKd:  757nMAssay Description:Displacement of (S)-1-((R)-2-amino-3-phenylpropanoyl)-N-(4-carbamimidoylbenzyl)pyrrolidine-2-carboxamide from bovine beta-trypsin in phosphate/HEPES/...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50511167(CHEMBL4563187)
Affinity DataKd:  38nMAssay Description:Binding affinity to bovine beta-trypsin in phosphate/HEPES/Tricine/Tris buffer by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50120225(2-{[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl...)
Affinity DataIC50: 0.00800nMAssay Description:Concentration required to inhibit Trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Human)TBA
LigandPNGBDBM50072292((3S,3aS,6aS)-3-Phenylsulfanyl-hexahydro-cyclopenta...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50228863(1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataIC50: 0.0450nMAssay Description:Concentration required to inhibit Trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Human)TBA
LigandPNGBDBM50072285((3R,3aS,6aS)-3-Phenylsulfanyl-hexahydro-cyclopenta...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Human)TBA
LigandPNGBDBM193290(US9199927, 1)
Affinity DataIC50: 0.170nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193360(US9199927, 71)
Affinity DataIC50: 0.180nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193349(US9199927, 108 | US9199927, 60)
Affinity DataIC50: 0.190nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193304(US9199927, 15)
Affinity DataIC50: 0.200nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193313(US9199927, 24)
Affinity DataIC50: 0.210nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193349(US9199927, 108 | US9199927, 60)
Affinity DataIC50: 0.210nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193369(US9199927, 80)
Affinity DataIC50: 0.210nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193414(US9199927, 96)
Affinity DataIC50: 0.220nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193303(US9199927, 14)
Affinity DataIC50: 0.230nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193305(US9199927, 16)
Affinity DataIC50: 0.230nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193350(US9199927, 61)
Affinity DataIC50: 0.230nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193317(US9199927, 28)
Affinity DataIC50: 0.240nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193395(US9199927, 113)
Affinity DataIC50: 0.240nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193310(US9199927, 21)
Affinity DataIC50: 0.260nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193316(US9199927, 27)
Affinity DataIC50: 0.260nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193319(US9199927, 30)
Affinity DataIC50: 0.260nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193348(US9199927, 59)
Affinity DataIC50: 0.270nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193311(US9199927, 22)
Affinity DataIC50: 0.290nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193314(US9199927, 25)
Affinity DataIC50: 0.290nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193315(US9199927, 26)
Affinity DataIC50: 0.290nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193351(US9199927, 62)
Affinity DataIC50: 0.290nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193415(US9199927, 102)
Affinity DataIC50: 0.290nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193341(US9199927, 52)
Affinity DataIC50: 0.300nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193318(US9199927, 29)
Affinity DataIC50: 0.310nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM193320(US9199927, 31)
Affinity DataIC50: 0.310nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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