Compile Data Set for Download or QSAR
Report error Found 5725 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase ATR'
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)
Affinity DataEC50:  35nMAssay Description:Inhibition of ATR in human HCT116 cells assessed as after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043407(CHEMBL3355476)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043409(CHEMBL3355474)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043385(CHEMBL3355072)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043387(CHEMBL3355074)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043408(CHEMBL3355475)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043382(CHEMBL3355069)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043384(CHEMBL3355071)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043411(CHEMBL3355480)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR [14-953](Human)
Shanghai De Novo Pharmatech Co.

US Patent
LigandPNGBDBM647614(US20240025899, Compound 3 | (R)-N,N-dimethyl-4-(3-...)
Affinity DataIC50: 0.510nMAssay Description:In this experiment, the phosphorylation level of substrate protein P53 (Eurofins, 14-952) was detected by HTRF technology to measure the activity of ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR [14-953](Human)
Shanghai De Novo Pharmatech Co.

US Patent
LigandPNGBDBM647613(US20240025899, Compound 2 | (R)-3-methyl-4-(1-(met...)
Affinity DataIC50: 0.690nMAssay Description:In this experiment, the phosphorylation level of substrate protein P53 (Eurofins, 14-952) was detected by HTRF technology to measure the activity of ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043383(CHEMBL3355070)
Affinity DataIC50: 1nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043410(CHEMBL3355473)
Affinity DataIC50: 1nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50468005(CHEMBL4288033)
Affinity DataIC50: 1nMAssay Description:Inhibition of ATR in human HeLa cell nuclear extract using GST-fused p53N66 as substrate preincubated for 10 mins followed by ATP addition and measur...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043386(CHEMBL3355073)
Affinity DataIC50: 1nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50617689(CHEMBL5394792)
Affinity DataIC50: 1nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase ATR [14-953](Human)
Shanghai De Novo Pharmatech Co.

US Patent
LigandPNGBDBM647612(US20240025899, Compound 1 | Synthesis of (R)-3-met...)
Affinity DataIC50: 1.20nMAssay Description:In this experiment, the phosphorylation level of substrate protein P53 (Eurofins, 14-952) was detected by HTRF technology to measure the activity of ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50617691(CHEMBL5417125)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM694826(US20240294550, Example 20)
Affinity DataIC50: 1.40nMAssay Description:This experiment adopted Homogeneous time-resolved fluorescence technology (HTRF ) of Cisbio Company for assay.Experiment method: buffers were prepare...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50617687(CHEMBL5434673)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase ATR [14-953](Human)
Shanghai De Novo Pharmatech Co.

US Patent
LigandPNGBDBM647615(US20240025899, Compound 4 | (R)-N,N-dimethyl-4-(3-...)
Affinity DataIC50: 1.80nMAssay Description:In this experiment, the phosphorylation level of substrate protein P53 (Eurofins, 14-952) was detected by HTRF technology to measure the activity of ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM616166(US20230271968, Compound A9)
Affinity DataIC50: 2nMAssay Description:Biotinylated protein derived from p53 (Eurofins, art. No.: 14-952) was phosphorylated with ATR kinase. The amount of phosphorylated protein was deter...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM616171(US20230271968, Compound A12)
Affinity DataIC50: 2nMAssay Description:Biotinylated protein derived from p53 (Eurofins, art. No.: 14-952) was phosphorylated with ATR kinase. The amount of phosphorylated protein was deter...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM616172(US20230271968, Compound A13)
Affinity DataIC50: 2nMAssay Description:Biotinylated protein derived from p53 (Eurofins, art. No.: 14-952) was phosphorylated with ATR kinase. The amount of phosphorylated protein was deter...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM616182(US20230271968, Compound A22)
Affinity DataIC50: 2nMAssay Description:Biotinylated protein derived from p53 (Eurofins, art. No.: 14-952) was phosphorylated with ATR kinase. The amount of phosphorylated protein was deter...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM616184(US20230271968, Compound A24)
Affinity DataIC50: 2nMAssay Description:Biotinylated protein derived from p53 (Eurofins, art. No.: 14-952) was phosphorylated with ATR kinase. The amount of phosphorylated protein was deter...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50468003(CHEMBL4281240)
Affinity DataIC50: 2nMAssay Description:Inhibition of ATR in human HeLa cell nuclear extract using GST-fused p53N66 as substrate preincubated for 10 mins followed by ATP addition and measur...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50468009(CHEMBL4286105)
Affinity DataIC50: 2nMAssay Description:Inhibition of ATR in human HeLa cell nuclear extract using GST-fused p53N66 as substrate preincubated for 10 mins followed by ATP addition and measur...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM459773(3,3-dimethyl-2-{2-[(3R)-3-methylmorpholin-4-yl]-8-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of 5'-TAMRA-labeled tracer 3',6'-bis(dimethylamino)-N-(4-{[2(1H-indol-4-yl)-6-(morpholin-4-yl)-pyrimidin-4-yl]amino}butyl)-3-oxo-3H-spiro[...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043389(CHEMBL3352844)
Affinity DataIC50: 2nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50620040(CHEMBL5424025)
Affinity DataIC50: 2nMAssay Description:Inhibition of ATR (unknown origin) using peptide as substrate preincubated for 10 mins followed by substrate addition by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50468002(CHEMBL4291436)
Affinity DataIC50: 2nMAssay Description:Inhibition of ATR in human HeLa cell nuclear extract using GST-fused p53N66 as substrate preincubated for 10 mins followed by ATP addition and measur...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50620042(CHEMBL5432859)
Affinity DataIC50: 2nMAssay Description:Inhibition of ATR (unknown origin) using peptide as substrate preincubated for 10 mins followed by substrate addition by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50617692(CHEMBL5397045)
Affinity DataIC50: 2nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50617680(CHEMBL5438872)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103469(US8552004, 2.07)
Affinity DataIC50: 2.58nMAssay Description:ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103481(US8552004, 2.08)
Affinity DataIC50: 2.76nMAssay Description:ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50617695(CHEMBL5421836)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50617684(CHEMBL5400072)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50617674(CHEMBL5399336)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM616167(US20230271968, Compound A10)
Affinity DataIC50: 3nMAssay Description:Biotinylated protein derived from p53 (Eurofins, art. No.: 14-952) was phosphorylated with ATR kinase. The amount of phosphorylated protein was deter...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM616173(US20230271968, Compound A14)
Affinity DataIC50: 3nMAssay Description:Biotinylated protein derived from p53 (Eurofins, art. No.: 14-952) was phosphorylated with ATR kinase. The amount of phosphorylated protein was deter...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM616177(US20230271968, Compound A17)
Affinity DataIC50: 3nMAssay Description:Biotinylated protein derived from p53 (Eurofins, art. No.: 14-952) was phosphorylated with ATR kinase. The amount of phosphorylated protein was deter...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Rabbit)
Bluevalley Pharmaceutical

US Patent
LigandPNGBDBM60432(BDBM50468001 | US8552004, 2.02 | US11236089, Compo...)
Affinity DataIC50: 3nMAssay Description:ATR for use in the in vitro enzyme assay was obtained from HeLa nuclear extract (CIL Biotech, Mons, Belgium) by immunoprecipitation with rabbit polyc...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Rabbit)
Bluevalley Pharmaceutical

US Patent
LigandPNGBDBM535716(US11236089, Compound CY-209 | US11236089, Compound...)
Affinity DataIC50: 3nMAssay Description:ATR for use in the in vitro enzyme assay was obtained from HeLa nuclear extract (CIL Biotech, Mons, Belgium) by immunoprecipitation with rabbit polyc...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Rabbit)
Bluevalley Pharmaceutical

US Patent
LigandPNGBDBM535716(US11236089, Compound CY-209 | US11236089, Compound...)
Affinity DataIC50: 3nMAssay Description:ATR for use in the in vitro enzyme assay was obtained from HeLa nuclear extract (CIL Biotech, Mons, Belgium) by immunoprecipitation with rabbit polyc...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Rabbit)
Bluevalley Pharmaceutical

US Patent
LigandPNGBDBM535718(US11236089, Compound CY-212)
Affinity DataIC50: 3nMAssay Description:ATR for use in the in vitro enzyme assay was obtained from HeLa nuclear extract (CIL Biotech, Mons, Belgium) by immunoprecipitation with rabbit polyc...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Rabbit)
Bluevalley Pharmaceutical

US Patent
LigandPNGBDBM535719(US11236089, Compound CY-237)
Affinity DataIC50: 3nMAssay Description:ATR for use in the in vitro enzyme assay was obtained from HeLa nuclear extract (CIL Biotech, Mons, Belgium) by immunoprecipitation with rabbit polyc...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Rabbit)
Bluevalley Pharmaceutical

US Patent
LigandPNGBDBM535720(US11236089, Compound CY-249)
Affinity DataIC50: 3nMAssay Description:ATR for use in the in vitro enzyme assay was obtained from HeLa nuclear extract (CIL Biotech, Mons, Belgium) by immunoprecipitation with rabbit polyc...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Rabbit)
Bluevalley Pharmaceutical

US Patent
LigandPNGBDBM535721(US11236089, Compound CY-257)
Affinity DataIC50: 3nMAssay Description:ATR for use in the in vitro enzyme assay was obtained from HeLa nuclear extract (CIL Biotech, Mons, Belgium) by immunoprecipitation with rabbit polyc...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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