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Report error Found 130 Enz. Inhib. hit(s) with Target = 'S-methyl-5'-thioadenosine phosphorylase'
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50170093(2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-di...)
Affinity DataKd:  1nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM22113(DADMe-ImmA-Me | (3R,4S)-1-({4-amino-5H-pyrrolo[3,2...)
Affinity DataKd:  0.0860nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM36494(CHEMBL554965 | ImmA-Et)
Affinity DataKd:  0.266nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM22113(DADMe-ImmA-Me | (3R,4S)-1-({4-amino-5H-pyrrolo[3,2...)
Affinity DataKd:  0.0340nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM36495(CHEMBL554642 | ImmA-Bn)
Affinity DataKd:  26nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM36497(CHEMBL191436 | DADMe-ImmA-Bn)
Affinity DataKd:  0.700nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM36496(CHEMBL552894 | ImmA-pClPh)
Affinity DataKd:  0.166nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM36498(DADMe-ImmA-p-ClPh)
Affinity DataKd:  0.0100nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50510218(CHEMBL4439603)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to recombinant human N-terminal TEV cleavage site-fused-His6-tagged MTAP expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL comp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50510219(CHEMBL4439224)
Affinity DataKd:  66nMAssay Description:Binding affinity to recombinant human N-terminal TEV cleavage site-fused-His6-tagged MTAP expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL comp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50510220(CHEMBL4555970)
Affinity DataKd:  70nMAssay Description:Binding affinity to recombinant human N-terminal TEV cleavage site-fused-His6-tagged MTAP expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL comp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50510221(CHEMBL4555691)
Affinity DataKd:  37nMAssay Description:Binding affinity to recombinant human N-terminal TEV cleavage site-fused-His6-tagged MTAP expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL comp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50510222(CHEMBL4586326)
Affinity DataKd:  32nMAssay Description:Binding affinity to recombinant human N-terminal TEV cleavage site-fused-His6-tagged MTAP expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL comp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50510223(CHEMBL4444249)
Affinity DataKd:  13nMAssay Description:Binding affinity to recombinant human N-terminal TEV cleavage site-fused-His6-tagged MTAP expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL comp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50510224(CHEMBL4451807)
Affinity DataKd:  13nMAssay Description:Binding affinity to recombinant human N-terminal TEV cleavage site-fused-His6-tagged MTAP expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL comp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50510225(CHEMBL4450105)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to recombinant human N-terminal TEV cleavage site-fused-His6-tagged MTAP expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL comp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50510226(CHEMBL4469129)
Affinity DataKd:  3nMAssay Description:Binding affinity to recombinant human N-terminal TEV cleavage site-fused-His6-tagged MTAP expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL comp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50510227(CHEMBL4445386)
Affinity DataKd:  0.630nMAssay Description:Binding affinity to recombinant human N-terminal TEV cleavage site-fused-His6-tagged MTAP expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL comp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50510228(CHEMBL4469234)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to recombinant human N-terminal TEV cleavage site-fused-His6-tagged MTAP expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL comp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50510229(CHEMBL4472065)
Affinity DataKd:  19nMAssay Description:Binding affinity to recombinant human N-terminal TEV cleavage site-fused-His6-tagged MTAP expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL comp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50510230(CHEMBL4465346)
Affinity DataKd:  0.940nMAssay Description:Binding affinity to recombinant human N-terminal TEV cleavage site-fused-His6-tagged MTAP expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL comp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50140797((2S,3S,4R,5S)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidi...)
Affinity DataIC50: 1.20nMAssay Description:Inhibitory concentration against Methylthioadenosine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50170092(1-(4-Amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of human MTAP as equilibrium dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50170082(1-(4-Amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-...)
Affinity DataKi:  0.0340nMAssay Description:Inhibition of human MTAP as equilibrium dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM22113(DADMe-ImmA-Me | (3R,4S)-1-({4-amino-5H-pyrrolo[3,2...)
Affinity DataKi:  0.0780nMAssay Description:Inhibition of human MTAP using methylthioadenosine as substrate assessed as inhibition constant for slow onset inhibition of enzyme-inhibitor complex...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50170089(1-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-ylmethyl)-...)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of human MTAP as equilibrium dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM22113(DADMe-ImmA-Me | (3R,4S)-1-({4-amino-5H-pyrrolo[3,2...)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50170086(1-(4-Amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-...)
Affinity DataKi:  0.110nMAssay Description:Inhibition of human MTAP as equilibrium dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50170095(1-(4-Amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-...)
Affinity DataKi:  0.120nMAssay Description:Inhibition of human MTAP as equilibrium dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50170098(1-(4-Amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human MTAP as equilibrium dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50170091(1-(4-Amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human MTAP as equilibrium dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM36496(CHEMBL552894 | ImmA-pClPh)
Affinity DataKi:  0.166nMAssay Description:Equilibrium dissociation constant towards human 5'-methylthioadenosine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50170083(1-(4-Amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-...)
Affinity DataKi:  0.170nMAssay Description:Inhibition of human MTAP as equilibrium dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50148131(2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-prop...)
Affinity DataKi:  0.214nMAssay Description:Equilibrium dissociation constant towards human 5'-methylthioadenosine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50170097(1-(4-Amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-...)
Affinity DataKi:  0.260nMAssay Description:Inhibition of human MTAP as equilibrium dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM36494(CHEMBL554965 | ImmA-Et)
Affinity DataKi:  0.266nMAssay Description:Equilibrium dissociation constant towards human 5'-methylthioadenosine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50170088(1-(4-Amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of human MTAP as equilibrium dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50170086(1-(4-Amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-...)
Affinity DataKi:  0.280nMAssay Description:Inhibition of human MTAP as initial dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50170092(1-(4-Amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of human MTAP as initial dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50170094(1-(4-Amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-...)
Affinity DataKi:  0.370nMAssay Description:Inhibition of human MTAP as equilibrium dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM22113(DADMe-ImmA-Me | (3R,4S)-1-({4-amino-5H-pyrrolo[3,2...)
Affinity DataKi:  0.530nMAssay Description:Inhibition of human MTAP using methylthioadenosine as substrate by xanthine oxidase coupling enzyme assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM36496(CHEMBL552894 | ImmA-pClPh)
Affinity DataKi:  0.576nMAssay Description:Initial dissociation constant towards human 5'-methylthioadenosine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50148132(2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-m-to...)
Affinity DataKi:  0.628nMAssay Description:Equilibrium dissociation constant towards human 5'-methylthioadenosine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50148134(2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-p-to...)
Affinity DataKi:  0.640nMAssay Description:Equilibrium dissociation constant towards human 5'-methylthioadenosine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50170082(1-(4-Amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-...)
Affinity DataKi:  0.650nMAssay Description:Inhibition of human MTAP as initial dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM36497(CHEMBL191436 | DADMe-ImmA-Bn)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human MTAP as equilibrium dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50170094(1-(4-Amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-...)
Affinity DataKi:  0.760nMAssay Description:Inhibition of human MTAP as initial dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50326399((+/-)-trans-4-Butyl-1-[(9-deazaadenin-9-yl)methyl]...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50326399((+/-)-trans-4-Butyl-1-[(9-deazaadenin-9-yl)methyl]...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Albert Einstein College of Medicine

LigandPNGBDBM50170098(1-(4-Amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-...)
Affinity DataKi:  0.810nMAssay Description:Inhibition of human MTAP as initial dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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