Compile Data Set for Download or QSAR
Report error Found 113 Enz. Inhib. hit(s) with Target = 'Ryanodine receptor'
TargetRyanodine receptor 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50241983(Bastadin-4 | CHEMBL453147 | Bastadin 4)
Affinity DataEC50:  1.47E+4nMAssay Description:Displacement of [3H]ryanodine from RyR1 calcium channel in sarcoplasmic reticulum assessed as calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50241984(CHEMBL505907 | BASTADIN 6 | bastadin-6)
Affinity DataEC50:  2.60E+3nMAssay Description:Displacement of [3H]ryanodine from RyR1 calcium channel in sarcoplasmic reticulum assessed as calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50241986(Bastadin-10 | CHEMBL504851)
Affinity DataEC50:  5.80E+3nMAssay Description:Displacement of [3H]ryanodine from RyR1 calcium channel in sarcoplasmic reticulum assessed as calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50241985(CHEMBL508830 | Bastadin-19 | CHEMBL506286 | (E,Z)b...)
Affinity DataEC50: >1.00E+5nMAssay Description:Displacement of [3H]ryanodine from RyR1 calcium channel in sarcoplasmic reticulum assessed as calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor(Fruit fly)
Fmc Stine Research Center

Curated by ChEMBL
LigandPNGBDBM50222771(3-bromo-N-(4-chloro-2-methyl-6-(methylcarbamoyl)ph...)
Affinity DataEC50:  40nMAssay Description:Activation of Drosophila melanogaster ryanodine receptor in Sf9 cells assessed as induction of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor 1(Mouse)
Fmc Stine Research Center

Curated by ChEMBL
LigandPNGBDBM50222771(3-bromo-N-(4-chloro-2-methyl-6-(methylcarbamoyl)ph...)
Affinity DataEC50:  1.40E+4nMAssay Description:Activation of ryanodine receptor 1 in mouse C2C12 cells assessed as induction of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor(Fruit fly)
Fmc Stine Research Center

Curated by ChEMBL
LigandPNGBDBM50222771(3-bromo-N-(4-chloro-2-methyl-6-(methylcarbamoyl)ph...)
Affinity DataEC50:  0.0500nMAssay Description:Activation of Drosophila melanogaster ryanodine receptor assessed as induction of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor 2(Rat)
Fmc Stine Research Center

Curated by ChEMBL
LigandPNGBDBM50222771(3-bromo-N-(4-chloro-2-methyl-6-(methylcarbamoyl)ph...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of ryanodine receptor 2 in rat PC12 cells assessed as induction of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor 1(Rabbit)
University of California

Curated by ChEMBL
LigandPNGBDBM50191286(Bastadin-5 | bastadin 5 | CHEMBL439151)
Affinity DataEC50:  2.00E+3nMAssay Description:Displacement of [3H]ryanodine from Ry1R/FKBP12 receptor complex in rabbit sarcoplasmic reticulumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor 1(Rabbit)
University of California

Curated by ChEMBL
LigandPNGBDBM50292366(10-sulfatobastadin 3 | CHEMBL450681)
Affinity DataEC50:  1.00E+5nMAssay Description:Displacement of [3H]ryanodine from Ry1R/FKBP12 receptor complex in rabbit sarcoplasmic reticulumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor 1(Rabbit)
University of California

Curated by ChEMBL
LigandPNGBDBM50292367(15,34-O-disulfatobastadin 7 | CHEMBL509326)
Affinity DataEC50:  1.36E+4nMAssay Description:Displacement of [3H]ryanodine from Ry1R/FKBP12 receptor complex in rabbit sarcoplasmic reticulumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor 1(Rabbit)
University of California

Curated by ChEMBL
LigandPNGBDBM50292368(bastadin 20 | CHEMBL498932)
Affinity DataEC50:  2.06E+4nMAssay Description:Displacement of [3H]ryanodine from Ry1R/FKBP12 receptor complex in rabbit sarcoplasmic reticulumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor 1(Rabbit)
University of California

Curated by ChEMBL
LigandPNGBDBM50241985(CHEMBL508830 | Bastadin-19 | CHEMBL506286 | (E,Z)b...)
Affinity DataEC50: >1.00E+5nMAssay Description:Displacement of [3H]ryanodine from Ry1R/FKBP12 receptor complex in rabbit sarcoplasmic reticulumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50191278((+/-)-5,17-dibromo-4-hydroxy-2-oxa-10-aza-tricyclo...)
Affinity DataEC50:  1.10E+4nMAssay Description:Binding affinity to RYR1 channels by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50191286(Bastadin-5 | bastadin 5 | CHEMBL439151)
Affinity DataEC50:  2.20E+3nMAssay Description:Binding affinity to RYR1 channels by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50150778(polybrominated diphenyl ether derivative | Bastadi...)
Affinity DataEC50:  6.30E+3nMAssay Description:Binding affinity to RYR1 channels by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50241985(CHEMBL508830 | Bastadin-19 | CHEMBL506286 | (E,Z)b...)
Affinity DataEC50: >1.00E+5nMAssay Description:Binding affinity to RYR1 channels by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor(Sea urchin)
Juntendo University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50238525(CHEMBL4106291)
Affinity DataEC50:  39nMAssay Description:Agonist activity at ryanodine receptor in Hemicentrotus pulcherrimus egg homogenate assessed as increase in intracellular calcium mobilization by Flu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor(Sea urchin)
Juntendo University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50238526(CHEMBL4106293)
Affinity DataEC50:  870nMAssay Description:Agonist activity at ryanodine receptor in Hemicentrotus pulcherrimus egg homogenate assessed as increase in intracellular calcium mobilization by Flu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor(Sea urchin)
Juntendo University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50238527(CHEMBL4106292)
Affinity DataEC50:  3.70E+4nMAssay Description:Agonist activity at ryanodine receptor in Hemicentrotus pulcherrimus egg homogenate assessed as increase in intracellular calcium mobilization by Flu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor(Sea urchin)
Juntendo University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50238528(CHEMBL4106294)
Affinity DataEC50:  1.20E+4nMAssay Description:Agonist activity at ryanodine receptor in Hemicentrotus pulcherrimus egg homogenate assessed as increase in intracellular calcium mobilization by Flu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor(Sea urchin)
Juntendo University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50238529(CHEMBL3350989)
Affinity DataEC50:  210nMAssay Description:Agonist activity at ryanodine receptor in Hemicentrotus pulcherrimus egg homogenate assessed as increase in intracellular calcium mobilization by Flu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor 2(Homo sapiens)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631111(CHEMBL5437537)
Affinity DataEC50:  8.17E+3nMAssay Description:Modulator activity at wild type RyR2 (unknown origin) expressed in HEK293T co-expressed with R-CEPIA1er assessed as decrease in RyR2-mediated calcium...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRyanodine receptor 2(Homo sapiens)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631112(CHEMBL5398491)
Affinity DataEC50:  82nMAssay Description:Modulator activity at wild type RyR2 (unknown origin) expressed in HEK293T co-expressed with R-CEPIA1er assessed as decrease in RyR2-mediated calcium...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRyanodine receptor 2(Homo sapiens)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631113(CHEMBL5413930)
Affinity DataEC50:  10nMAssay Description:Modulator activity at wild type RyR2 (unknown origin) expressed in HEK293T co-expressed with R-CEPIA1er assessed as decrease in RyR2-mediated calcium...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRyanodine receptor 2(Homo sapiens)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631114(CHEMBL5435124)
Affinity DataEC50:  2.70E+3nMAssay Description:Modulator activity at wild type RyR2 (unknown origin) expressed in HEK293T co-expressed with R-CEPIA1er assessed as decrease in RyR2-mediated calcium...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRyanodine receptor 2(Homo sapiens)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631115(CHEMBL5426069)
Affinity DataEC50: >2.30E+4nMAssay Description:Modulator activity at wild type RyR2 (unknown origin) expressed in HEK293T co-expressed with R-CEPIA1er assessed as decrease in RyR2-mediated calcium...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRyanodine receptor 2(Homo sapiens)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631116(CHEMBL5409619)
Affinity DataEC50:  19nMAssay Description:Modulator activity at wild type RyR2 (unknown origin) expressed in HEK293T co-expressed with R-CEPIA1er assessed as decrease in RyR2-mediated calcium...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430056(US10538528, Compound 43)
Affinity DataIC50: 0.400nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430051(US10538528, Compound 37)
Affinity DataIC50: 0.5nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430057(US10538528, Compound 44)
Affinity DataIC50: 0.5nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430047(US10538528, Compound 32)
Affinity DataIC50: 0.600nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430052(US10538528, Compound 39)
Affinity DataIC50: 0.600nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430053(US10538528, Compound 40)
Affinity DataIC50: 0.600nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430029(US10538528, Compound 5)
Affinity DataIC50: 0.700nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430030(US10538528, Compound 11)
Affinity DataIC50: 0.700nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430034(US10538528, Compound 16)
Affinity DataIC50: 0.800nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430063(US10538528, Compound 10)
Affinity DataIC50: 0.900nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430037(US10538528, Compound 19)
Affinity DataIC50: 0.900nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430038(US10538528, Compound 20)
Affinity DataIC50: 0.900nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430050(US10538528, Compound 34)
Affinity DataIC50: 0.900nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430066(US10538528, Compound 38)
Affinity DataIC50: 0.900nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430059(US10538528, Compound 6)
Affinity DataIC50: 1nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430049(US10538528, Compound 33)
Affinity DataIC50: 1nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1(Rabbit)
University of California

Curated by ChEMBL
LigandPNGBDBM50044989((O10eq)-beta-guanidinopropionylryanodine | CHEMBL2...)
Affinity DataIC50: 1.10nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430062(US10538528, Compound 9)
Affinity DataIC50: 1.10nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430033(US10538528, Compound 15)
Affinity DataIC50: 1.10nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430035(US10538528, Compound 17)
Affinity DataIC50: 1.10nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430055(US10538528, Compound 42)
Affinity DataIC50: 1.20nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430039(US10538528, Compound 21)
Affinity DataIC50: 1.30nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Displayed 1 to 50 (of 113 total ) | Next | Last >>
Jump to: