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Report error Found 124 Enz. Inhib. hit(s) with Target = 'Rho-associated protein kinase 1/2'
TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148407(US9682963, 1)
Affinity DataEC50:  550nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148408(US9682963, 2)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148409(US9682963, 3)
Affinity DataEC50:  550nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148410(US9682963, 4)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148412(US9682963, 5)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148413(US9682963, 6)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148414(US9682963, 7)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148415(US9682963, 8)
Affinity DataEC50:  550nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148416(US9682963, 9)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148421(US9682963, 11)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148423(US9682963, 12)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148425(US9682963, 13)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM25472(N-[4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benz...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human ROCK incubated for 20 mins followed by 33P ATP after 120 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196700(N-[1-(3-nitrobenzyl)-3-piperidyl]-N-(1H-5-indazoly...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196694(N-(1-(thiophen-3-ylmethyl)piperidin-3-yl)-1H-indaz...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196718(N-(1-(thiophen-2-ylmethyl)piperidin-3-yl)-1H-indaz...)
Affinity DataIC50: 5nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196692(N-(1-(4-methylbenzyl)piperidin-3-yl)-1H-indazol-5-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196690(N-(1-(4-aminobenzyl)piperidin-3-yl)-1H-indazol-5-a...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196695(N-(1-(3,4-difluorobenzyl)piperidin-3-yl)-1H-indazo...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196711(1-benzyl-3-piperidyl-(1H-5-indazolyl)ether | 5-(1-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196682(N-(1-(4-chlorobenzyl)piperidin-3-yl)-1H-indazol-5-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196689(N-[1-(1H-2-pyrrolylmethyl)-3-piperidyl]-N-(1H-5-in...)
Affinity DataIC50: 11nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50506948(CHEMBL4448806)
Affinity DataIC50: 12nMAssay Description:Inhibition of ROCK1/2 in human PANC1 cells assessed as reduction in MYPT1 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50519606(CHEMBL4448462)
Affinity DataIC50: 12nMAssay Description:Inhibition of human ROCK incubated for 20 mins followed by 33P ATP after 120 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196707(N-[1-(2-chlorobenzyl)-3-piperidyl]-N-(1H-5-indazol...)
Affinity DataIC50: 13nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196712(N-(1-(4-methoxybenzyl)piperidin-3-yl)-1H-indazol-5...)
Affinity DataIC50: 16nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196704(1-benzyl-N-(1H-indazol-5-yl)piperidine-3-carboxami...)
Affinity DataIC50: 18nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196728(N-[1-(3-chlorobenzyl)-3-piperidyl]-N-(1H-5-indazol...)
Affinity DataIC50: 19nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196687(1-(2,6-dichlorophenyl)-3-(3H-indazol-5-yl)urea | 1...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196725(N-(1-benzylpiperidin-3-yl)-1H-indazol-5-amine | N-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196725(N-(1-benzylpiperidin-3-yl)-1H-indazol-5-amine | N-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196698(N-[1-(3-chlorobenzyl)-3-pyrrolidyl]-N-(1H-5-indazo...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196686(N-[1-(4-chlorobenzyl)-3-pyrrolidyl]-N-(1H-5-indazo...)
Affinity DataIC50: 24nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50197913((3R)-N-[1-(3-aminobenzyl)-3-pyrrolidyl]-N-(5-isoqu...)
Affinity DataIC50: 25nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196688(N-(1-(4-fluorobenzyl)piperidin-3-yl)-1H-indazol-5-...)
Affinity DataIC50: 25nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196708(N-(1-benzylpyrrolidin-3-yl)-1H-indazol-5-amine | N...)
Affinity DataIC50: 32nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196699(N-[1-(3-aminobenzyl)-3-piperidyl]-N-(1H-5-indazoly...)
Affinity DataIC50: 35nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196679(N-[1-(2-chlorobenzyl)-3-pyrrolidyl]-N-(1H-5-indazo...)
Affinity DataIC50: 45nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50506928(CHEMBL4469434)
Affinity DataIC50: 56nMAssay Description:Inhibition of ROCK1/2 in human PANC1 cells assessed as reduction in MYPT1 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50197914(N-(1-(4-chlorobenzyl)pyrrolidin-3-yl)isoquinolin-5...)
Affinity DataIC50: 65nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50197915(N-(1-(3-chlorobenzyl)pyrrolidin-3-yl)isoquinolin-5...)
Affinity DataIC50: 65nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196706(N-(1-(furan-2-ylmethyl)piperidin-3-yl)-1H-indazol-...)
Affinity DataIC50: 65nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50197922(anti-N1-cyclopropyl-N4-(isoquinolin-5-yl)cyclohexa...)
Affinity DataIC50: 70nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196683(N-[1-(3-pyridylmethyl)-3-piperidyl]-N-(1H-5-indazo...)
Affinity DataIC50: 72nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50197907(N-(1-(2,6-difluorobenzyl)pyrrolidin-3-yl)isoquinol...)
Affinity DataIC50: 75nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50506932(CHEMBL2006299)
Affinity DataIC50: 75nMAssay Description:Inhibition of ROCK1/2 in human PANC1 cells assessed as reduction in MYPT1 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196685(N-(1-(3,5-dimethoxybenzyl)piperidin-3-yl)-1H-indaz...)
Affinity DataIC50: 80nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196681(N-(2,6-difluorobenzyl)-N0-(1H-5-indazolyl)urea | 1...)
Affinity DataIC50: 85nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196702(N-[1-(2-aminobenzyl)-3-piperidyl]-N-(1H-5-indazoly...)
Affinity DataIC50: 85nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50196691(N-(1-(4-nitrobenzyl)piperidin-3-yl)-1H-indazol-5-a...)
Affinity DataIC50: 87nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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