Compile Data Set for Download or QSAR
Report error Found 1381 Enz. Inhib. hit(s) with Target = 'Vitamin D3 receptor'
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  7.70nMAssay Description:Agonist activity at human VDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50437333(CHEMBL2407826)
Affinity DataEC50:  0.680nMAssay Description:Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50437334(CHEMBL2407825)
Affinity DataEC50:  0.210nMAssay Description:Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50437335(CHEMBL2407824)
Affinity DataEC50:  0.0440nMAssay Description:Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50437336(CHEMBL2407823)
Affinity DataEC50:  0.150nMAssay Description:Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50437337(CHEMBL2407822)
Affinity DataEC50:  0.290nMAssay Description:Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50437338(CHEMBL2407821)
Affinity DataEC50:  0.0100nMAssay Description:Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  0.0260nMAssay Description:Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50329704((R)-3-(4-(3-(4-((R)-2-hydroxy-3,3-dimethylbutoxy)-...)
Affinity DataEC50:  26nMAssay Description:Vitamin-D activity at VDR receptor in human HL60 cells assessed as induction of cell differentiation by NBT reduction assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50329707((S)-3-(4-(3-(4-((S)-2-hydroxy-3,3-dimethylbutoxy)-...)
Affinity DataEC50:  23nMAssay Description:Vitamin-D activity at VDR receptor in human HL60 cells assessed as induction of cell differentiation by NBT reduction assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50329706((2S)-3-{4-[1-ethyl-1-(4-{[(2R)-2-hydroxy-3,3-dimet...)
Affinity DataEC50:  8.60nMAssay Description:Vitamin-D activity at VDR receptor in human HL60 cells assessed as induction of cell differentiation by NBT reduction assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Mouse)
Tokyo Medical and Dental University

Curated by ChEMBL
LigandPNGBDBM50244240((20S)-(2E)-1-alpha-25-Dihydroxy-2-[2-(hydroxy)-eth...)
Affinity DataEC50:  0.0260nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Mouse)
Tokyo Medical and Dental University

Curated by ChEMBL
LigandPNGBDBM50412385(CHEMBL2021488)
Affinity DataEC50:  0.0900nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Mouse)
Tokyo Medical and Dental University

Curated by ChEMBL
LigandPNGBDBM50005618(CHEMBL2021484)
Affinity DataEC50:  0.00210nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Mouse)
Tokyo Medical and Dental University

Curated by ChEMBL
LigandPNGBDBM50244241((20R)-(2E)-1-alpha-25-Dihydroxy-2-[2-(hydroxy)-eth...)
Affinity DataEC50:  0.200nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Mouse)
Tokyo Medical and Dental University

Curated by ChEMBL
LigandPNGBDBM50244165(CHEMBL514116 | (20R)-1-alpha,25-Dihydroxy-2-alpha-...)
Affinity DataEC50:  0.0240nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Mouse)
Tokyo Medical and Dental University

Curated by ChEMBL
LigandPNGBDBM50244269(CHEMBL513573 | (20R)-1-alpha-2-alpha-25-Trihydroxy...)
Affinity DataEC50:  0.120nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Mouse)
Tokyo Medical and Dental University

Curated by ChEMBL
LigandPNGBDBM50412386(CHEMBL2021486)
Affinity DataEC50:  0.0580nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Mouse)
Tokyo Medical and Dental University

Curated by ChEMBL
LigandPNGBDBM50244241((20R)-(2E)-1-alpha-25-Dihydroxy-2-[2-(hydroxy)-eth...)
Affinity DataEC50:  0.0290nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Mouse)
Tokyo Medical and Dental University

Curated by ChEMBL
LigandPNGBDBM50244165(CHEMBL514116 | (20R)-1-alpha,25-Dihydroxy-2-alpha-...)
Affinity DataEC50:  0.115nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Mouse)
Tokyo Medical and Dental University

Curated by ChEMBL
LigandPNGBDBM50244268((20S)-1-alpha-2-alpha-25-Trihydroxy-2beta-methyl-1...)
Affinity DataEC50:  1.90nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50397074(CHEMBL2171447)
Affinity DataEC50:  1.70nMAssay Description:Transactivation of GAL4-fused VDR ligand binding domain expressed in human HeLa cells after 16 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  1nMAssay Description:Transactivation of GAL4-fused VDR ligand binding domain expressed in human HeLa cells after 16 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Mouse)
Tokyo Medical and Dental University

Curated by ChEMBL
LigandPNGBDBM50244269(CHEMBL513573 | (20R)-1-alpha-2-alpha-25-Trihydroxy...)
Affinity DataEC50:  4.5nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015315(CHEMBL3263870)
Affinity DataEC50:  6.60nMAssay Description:Transactivation of human VDR expressed in HEK293 cells cotransfected with mouse VDRE, Tk-Sppx3-LUC reporter plasmid measured after 24 hrs by lucifera...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015316(CHEMBL3263873)
Affinity DataEC50:  1.10nMAssay Description:Transactivation of human VDR expressed in HEK293 cells cotransfected with mouse VDRE, Tk-Sppx3-LUC reporter plasmid measured after 24 hrs by lucifera...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015317(CHEMBL3263872)
Affinity DataEC50:  1.5nMAssay Description:Transactivation of human VDR expressed in HEK293 cells cotransfected with mouse VDRE, Tk-Sppx3-LUC reporter plasmid measured after 24 hrs by lucifera...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015318(CHEMBL3263871)
Affinity DataEC50:  0.0700nMAssay Description:Transactivation of human VDR expressed in HEK293 cells cotransfected with mouse VDRE, Tk-Sppx3-LUC reporter plasmid measured after 24 hrs by lucifera...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015318(CHEMBL3263871)
Affinity DataEC50:  0.600nMAssay Description:Activation of human VDR expressed in HEK293 cells cotransfected CMX-GAL4-RXRalpha and 4-tk-LUC assessed as heterodimerization with RXRalpha by mammal...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015317(CHEMBL3263872)
Affinity DataEC50:  2.30nMAssay Description:Activation of human VDR expressed in HEK293 cells cotransfected CMX-GAL4-RXRalpha and 4-tk-LUC assessed as heterodimerization with RXRalpha by mammal...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015316(CHEMBL3263873)
Affinity DataEC50:  0.800nMAssay Description:Activation of human VDR expressed in HEK293 cells cotransfected CMX-GAL4-RXRalpha and 4-tk-LUC assessed as heterodimerization with RXRalpha by mammal...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015315(CHEMBL3263870)
Affinity DataEC50:  15nMAssay Description:Activation of human VDR expressed in HEK293 cells cotransfected CMX-GAL4-SRC1 and 4-tk-LUC assessed as SRC1 interaction with AF2 surface of VDR by ma...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015318(CHEMBL3263871)
Affinity DataEC50:  1.5nMAssay Description:Activation of human VDR expressed in HEK293 cells cotransfected CMX-GAL4-SRC1 and 4-tk-LUC assessed as SRC1 interaction with AF2 surface of VDR by ma...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015317(CHEMBL3263872)
Affinity DataEC50:  6.5nMAssay Description:Activation of human VDR expressed in HEK293 cells cotransfected CMX-GAL4-SRC1 and 4-tk-LUC assessed as SRC1 interaction with AF2 surface of VDR by ma...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015316(CHEMBL3263873)
Affinity DataEC50:  14nMAssay Description:Activation of human VDR expressed in HEK293 cells cotransfected CMX-GAL4-SRC1 and 4-tk-LUC assessed as SRC1 interaction with AF2 surface of VDR by ma...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015315(CHEMBL3263870)
Affinity DataEC50:  4nMAssay Description:Activation of human VDR expressed in HEK293 cells cotransfected CMX-GAL4-N-CoR and 4-tk-LUC assessed as inhibition of N-CoR binding to VDR by mammali...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015318(CHEMBL3263871)
Affinity DataEC50:  0.400nMAssay Description:Activation of human VDR expressed in HEK293 cells cotransfected CMX-GAL4-N-CoR and 4-tk-LUC assessed as inhibition of N-CoR binding to VDR by mammali...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015317(CHEMBL3263872)
Affinity DataEC50:  3.70nMAssay Description:Activation of human VDR expressed in HEK293 cells cotransfected CMX-GAL4-N-CoR and 4-tk-LUC assessed as inhibition of N-CoR binding to VDR by mammali...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015316(CHEMBL3263873)
Affinity DataEC50:  1.80nMAssay Description:Activation of human VDR expressed in HEK293 cells cotransfected CMX-GAL4-N-CoR and 4-tk-LUC assessed as inhibition of N-CoR binding to VDR by mammali...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015315(CHEMBL3263870)
Affinity DataEC50:  4.10nMAssay Description:Activation of human VDR expressed in HEK293 cells cotransfected CMX-GAL4-NCoR2 and 4-tk-LUC assessed as inhibition of NCoR2 binding to VDR by mammali...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015318(CHEMBL3263871)
Affinity DataEC50:  0.5nMAssay Description:Activation of human VDR expressed in HEK293 cells cotransfected CMX-GAL4-NCoR2 and 4-tk-LUC assessed as inhibition of NCoR2 binding to VDR by mammali...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015317(CHEMBL3263872)
Affinity DataEC50:  2.40nMAssay Description:Activation of human VDR expressed in HEK293 cells cotransfected CMX-GAL4-NCoR2 and 4-tk-LUC assessed as inhibition of NCoR2 binding to VDR by mammali...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015316(CHEMBL3263873)
Affinity DataEC50:  2.80nMAssay Description:Activation of human VDR expressed in HEK293 cells cotransfected CMX-GAL4-NCoR2 and 4-tk-LUC assessed as inhibition of NCoR2 binding to VDR by mammali...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50015315(CHEMBL3263870)
Affinity DataEC50:  4.40nMAssay Description:Activation of human VDR expressed in HEK293 cells cotransfected CMX-GAL4-RXRalpha and 4-tk-LUC assessed as heterodimerization with RXRalpha by mammal...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50236238(5beta-cholanic acid-3alpha-ol | CHEMBL1478 | (3alp...)
Affinity DataKd:  330nMAssay Description:Binding affinity to N-terminal His-tagged human VDR LBD canonical site (118 to 427) by direct isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50236238(5beta-cholanic acid-3alpha-ol | CHEMBL1478 | (3alp...)
Affinity DataKd:  9.52E+3nMAssay Description:Binding affinity to N-terminal His-tagged human VDR LBD low-affinity site (118 to 427) by direct isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50236238(5beta-cholanic acid-3alpha-ol | CHEMBL1478 | (3alp...)
Affinity DataKd:  1.89E+4nMAssay Description:Binding affinity to N-terminal His-tagged human VDR LBD (118 to 427) by reverse isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50030475(CHEBI:28940 | 7-Dehydrocholesterol | Cholecalcifer...)
Affinity DataEC50:  0.210nMAssay Description:Agonist activity at human VDR expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50143770((1R,3S)-5-[2-[(3aS,7aR)-1-((R)-5-Hydroxy-1,5-dimet...)
Affinity DataEC50:  0.180nMAssay Description:Effective concentration required for inhibition of Vitamin D3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin D3 receptor(Human)
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  7.70nMAssay Description:Inhibition of human VDR-cofactor interaction by EnBio receptor cofactor assay systemMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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