Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with Target = 'Receptor protein-tyrosine kinase'
TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 2nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276745(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
Affinity DataIC50: 2nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 2nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276745(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
Affinity DataIC50: 2nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM466797(US10800764, Compound (I-M7-2S,4R))
Affinity DataIC50: 6.60nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276746(US10071991, Compound (I-M7-2S,4R) | US11214566, Co...)
Affinity DataIC50: 6.60nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 8nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM532954(US11214566, Compound (I-M7-2R,4S))
Affinity DataIC50: 8nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276743(US10071991, Compound (P) | US9611259, Compound (P)...)
Affinity DataIC50: 16nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276743(US10071991, Compound (P) | US9611259, Compound (P)...)
Affinity DataIC50: 16nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor protein-tyrosine kinase(Human)
Shandong Institute of Pharmaceutical Industry

LigandPNGBDBM108059(N-carbamimidoyl-4-((4-((2,3-dimethyl-2H-indazole- ...)
Affinity DataIC50: 1.37E+3nMT: 2°CAssay Description:To the assay kit, 2.5 µL of different concentrate of the test compounds, Pazopanib or water (control) were added and incubated for 1 h at room t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor protein-tyrosine kinase/Serine/threonine-protein kinase mTOR(Human)
University of California San Francisco

LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 4.40E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor protein-tyrosine kinase(Human)
Shandong Institute of Pharmaceutical Industry

LigandPNGBDBM26474(GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...)
Affinity DataIC50: 5.95E+3nMT: 2°CAssay Description:To the assay kit, 2.5 µL of different concentrate of the test compounds, Pazopanib or water (control) were added and incubated for 1 h at room t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed