Compile Data Set for Download or QSAR
Report error Found 102 Enz. Inhib. hit(s) with Target = 'Ras guanyl-releasing protein 3'
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50099066(phorbol 13-acetate 12-myristate | CHEMBL279115)
Affinity DataEC50:  82nMAssay Description:Activation of GFP-tagged RasGRP3 (unknown origin) expressed in HEK293 cells after 30 mins by immunoblot methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  860nMAssay Description:Activation of RasGRP3 in human Ramos cells after 30 mins by immunoblot methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  6.09E+3nMAssay Description:Activation of RasGRP3 in human Ramos cells assessed as ERK1/2 phosphorylation after 30 mins by immunoblot methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  1.83E+3nMAssay Description:Activation of GFP-tagged RasGRP3 (unknown origin) expressed in HEK293 cells after 30 mins by immunoblot methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  640nMAssay Description:Activation of GFP-tagged RasGRP3 (unknown origin) expressed in human LNCAP cells after 30 mins by immunoblot methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  4.66E+3nMAssay Description:Activation of GFP-tagged RasGRP3 (unknown origin) expressed in HEK293 cells assessed as ERK1/2 phosphorylation after 30 mins by immunoblot methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataEC50:  2.98E+3nMAssay Description:Activation of GFP-tagged RasGRP3 (unknown origin) expressed in human LNCAP cells assessed as ERK1/2 phosphorylation after 30 mins by immunoblot metho...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244449((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]PDBu from RasGRP3 expressed in cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244450((E)-(2-(hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethyl...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]PDBu from RasGRP3 expressed in cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244449((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]PDBu from recombinant human GFP-tagged RasGRP3 expressed in Escherichia coli BL21 after 5 mins by scintillation counting analysis...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50017890(CHEMBL3289012)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]PDBu from recombinant human GFP-tagged RasGRP3 expressed in Escherichia coli BL21 after 5 mins by scintillation counting analysis...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50245022((E)-(2-(hydroxymethyl)-5-oxo-4-(quinolin-3-ylmethy...)
Affinity DataKi:  0.520nMAssay Description:Displacement of [3H]PDBu from RasGRP3 expressed in cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280750(CHEMBL4160361)
Affinity DataKi:  0.530nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244451((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]PDBu from RasGRP3 expressed in cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244979((E)-(2-(hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethyl...)
Affinity DataKi:  0.720nMAssay Description:Displacement of [3H]PDBu from RasGRP3 expressed in cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244449((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...)
Affinity DataKi:  0.840nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280765(CHEMBL4160647)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50017892(CHEMBL3289014)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]PDBu from recombinant human GFP-tagged RasGRP3 expressed in Escherichia coli BL21 after 5 mins by scintillation counting analysis...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280759(CHEMBL4162516)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280768(CHEMBL4163130)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50017891(CHEMBL3289013)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]PDBu from recombinant human GFP-tagged RasGRP3 expressed in Escherichia coli BL21 after 5 mins by scintillation counting analysis...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280751(CHEMBL4174397)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50017889(CHEMBL3289011)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]PDBu from recombinant human GFP-tagged RasGRP3 expressed in Escherichia coli BL21 after 5 mins by scintillation counting analysis...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244981((E)-(2-(hydroxymethyl)-5-oxo-4-(pyridin-3-ylmethyl...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]PDBu from RasGRP3 expressed in cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50245020((E)-(2-(hydroxymethyl)-5-oxo-4-(quinolin-2-ylmethy...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]PDBu from RasGRP3 expressed in cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280773(CHEMBL4174723)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244866(rac-(E)-{2-(Hydroxymethyl)-4-[(4-nitrophenyl)methy...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to RasGRP3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280756(CHEMBL4167589)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280749(CHEMBL4169454)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280771(CHEMBL4160540)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280752(CHEMBL4161221)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50245091(rac-(E)-{2-(Hydroxymethyl)-4-[(4-nitrophenyl)methy...)
Affinity DataKi:  2.22nMAssay Description:Binding affinity to RasGRP3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244865(rac-(E)-{2-(Hydroxymethyl)-4-[(4-nitrophenyl)methy...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to RasGRP3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280757(CHEMBL4175934)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280758(CHEMBL4172461)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280754(CHEMBL4175128)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280772(CHEMBL4165117)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280745(CHEMBL4163809)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280753(CHEMBL4167900)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244481((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]PDBu from RasGRP3 expressed in cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280763(CHEMBL4175761)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244974((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]PDBu from RasGRP3 expressed in cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244482(rac-(E)-{2-(Hydroxymethyl)-4-[(4-nitrophenyl)methy...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity to RasGRP3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244482(rac-(E)-{2-(Hydroxymethyl)-4-[(4-nitrophenyl)methy...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]PDBu from RasGRP3 expressed in cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244915(rac-(E)-{2-(Hydroxymethyl)-4-[(3-nitrophenyl)methy...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to RasGRP3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244856(rac-(E/Z)-(4-(4-methoxybenzylidene)-2-(hydroxymeth...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280755(CHEMBL4175333)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50280746(CHEMBL4161062)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50245021((Z)-(2-(hydroxymethyl)-5-oxo-4-(quinolin-2-ylmethy...)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]PDBu from RasGRP3 expressed in cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244643(rac-(E)-(4-{[4-(Dimethylamino)phenyl]methylene}-2-...)
Affinity DataKi:  4.68nMAssay Description:Binding affinity to RasGRP3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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