Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with Target = 'RNA-directed RNA polymerase catalytic subunit' Sort by
TargetRNA-directed RNA polymerase catalytic subunit(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataEC50:  2.40E+4nMAssay Description:Inhibition of RdRP activity in Influenza A virus A/PR/8/34 (H1N1) infected in HEK293T cells co-transfected with NP/PA/PB1/PB2/pPolI-Flu-ffLuc/pRL-SV4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase catalytic subunit(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50577041(CHEMBL4870823)
Affinity DataEC50:  2.10E+4nMAssay Description:Inhibition of RdRP activity in Influenza A virus A/PR/8/34(H1N1) infected in HEK293T cells incubated for 24 hrs by minireplicon based dual luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase catalytic subunit(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of RdRP activity in Influenza A virus A/PR/8/34(H1N1) infected in HEK293T cells incubated for 24 hrs by minireplicon based dual luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase catalytic subunit/Polymerase basic protein 1/Polymerase basic protein 2(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Jiaxing Andicon Biotech Co.

US Patent
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447 | US12161646, Exa...)
Affinity DataEC50:  0.680nMAssay Description:MDCK cells were seeded in a 96-well cell culture plate, and cultured till cell attachment for later use. The drug was serially 3 times diluted from 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetRNA-directed RNA polymerase catalytic subunit/Polymerase basic protein 1/Polymerase basic protein 2(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Jiaxing Andicon Biotech Co.

US Patent
LigandPNGBDBM707291(US12161646, Example 2A)
Affinity DataEC50:  1.24nMAssay Description:MDCK cells were seeded in a 96-well cell culture plate, and cultured till cell attachment for later use. The drug was serially 3 times diluted from 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/21/2025
Entry Details
Go to US Patent

TargetRNA-directed RNA polymerase catalytic subunit/Polymerase basic protein 1/Polymerase basic protein 2(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Jiaxing Andicon Biotech Co.

US Patent
LigandPNGBDBM707292(US12161646, Example 3A)
Affinity DataEC50:  0.600nMAssay Description:MDCK cells were seeded in a 96-well cell culture plate, and cultured till cell attachment for later use. The drug was serially 3 times diluted from 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/21/2025
Entry Details
Go to US Patent

TargetRNA-directed RNA polymerase catalytic subunit/Polymerase basic protein 1/Polymerase basic protein 2(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Jiaxing Andicon Biotech Co.

US Patent
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447 | US12161646, Exa...)
Affinity DataEC50:  1.22nMAssay Description:MDCK cells were seeded in a 96-well cell culture plate, and cultured till cell attachment for later use. The drug was serially 3 times diluted from 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetRNA-directed RNA polymerase catalytic subunit/Polymerase basic protein 1/Polymerase basic protein 2(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Jiaxing Andicon Biotech Co.

US Patent
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447 | US12161646, Exa...)
Affinity DataIC50: 1.14nMAssay Description:2.5 μL of enzymatic reaction mixture (composition: 53 mM Tris hydrochloride (pH 7.8), 1 mM MgCl2, 1.25 mM dithiothreitol, 80 mM NaCl, 12.5% glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetRNA-directed RNA polymerase catalytic subunit/Polymerase basic protein 1/Polymerase basic protein 2(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Jiaxing Andicon Biotech Co.

US Patent
LigandPNGBDBM707292(US12161646, Example 3A)
Affinity DataIC50: 1.65nMAssay Description:2.5 μL of enzymatic reaction mixture (composition: 53 mM Tris hydrochloride (pH 7.8), 1 mM MgCl2, 1.25 mM dithiothreitol, 80 mM NaCl, 12.5% glycerol,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/21/2025
Entry Details
Go to US Patent

TargetRNA-directed RNA polymerase catalytic subunit/Polymerase basic protein 1/Polymerase basic protein 2(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Jiaxing Andicon Biotech Co.

US Patent
LigandPNGBDBM707291(US12161646, Example 2A)
Affinity DataIC50: 1.89nMAssay Description:2.5 μL of enzymatic reaction mixture (composition: 53 mM Tris hydrochloride (pH 7.8), 1 mM MgCl2, 1.25 mM dithiothreitol, 80 mM NaCl, 12.5% glycerol,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/21/2025
Entry Details
Go to US Patent

TargetRNA-directed RNA polymerase catalytic subunit/Polymerase basic protein 1/Polymerase basic protein 2(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Jiaxing Andicon Biotech Co.

US Patent
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447 | US12161646, Exa...)
Affinity DataIC50: 2.01nMAssay Description:2.5 μL of enzymatic reaction mixture (composition: 53 mM Tris hydrochloride (pH 7.8), 1 mM MgCl2, 1.25 mM dithiothreitol, 80 mM NaCl, 12.5% glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)