Compile Data Set for Download or QSAR
Report error Found 6083 Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret [V804M]'
LigandPNGBDBM576988(US11472802, Example 8)
Affinity DataIC50: 0.0170nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM677845(US20240174674, Compound 4)
Affinity DataIC50: 0.0300nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
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US Patent

LigandPNGBDBM677850(US20240174674, Compound 42)
Affinity DataIC50: 0.0500nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM677852(US20240174674, Compound 46)
Affinity DataIC50: 0.0600nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM677844(US20240174674, Compound 3 | US20240174674, Compoun...)
Affinity DataIC50: 0.100nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM677846(US20240174674, Compound 11)
Affinity DataIC50: 0.100nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM677848(US20240174674, Compound 40)
Affinity DataIC50: 0.100nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM677847(US20240174674, Compound 39)
Affinity DataIC50: 0.100nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM677849(US20240174674, Compound 41)
Affinity DataIC50: 0.100nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM677851(US20240174674, Compound 44)
Affinity DataIC50: 0.100nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM701992(4-(6-(6-((6-methoxypyridin-3-yl)methyl-d2)-3,6-dia...)
Affinity DataIC50: 0.160nMMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM701918(4-(6-(6-((6-(methoxy-d3)pyridin-3-yl)methyl)-3,6-d...)
Affinity DataIC50: 0.170nMMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM677853(US20240174674, Compound 88)
Affinity DataIC50: 0.200nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM701997(4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazab...)
Affinity DataIC50: 0.210nMMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM701995(4-(6-(6-((6-methoxypyridin-3-yl)methyl-d2)-3,6-dia...)
Affinity DataIC50: 0.230nMMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM702009(6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-(methoxy...)
Affinity DataIC50: 0.270nMMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM701993(4-(6-(6-((6-(methoxy-d3)pyridin-3-yl)methyl-d2)-3,...)
Affinity DataIC50: 0.290nMMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM311699(Ex. Cpd. 151 | US10807986, Example 151 | US1104669...)
Affinity DataIC50: 0.300nMAssay Description:RET (V804M) (i.e., RET with V804M mutation) kinase activity was measured using purified recombinant human RET (V804M) protein purchased from Eurofins...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311699(Ex. Cpd. 151 | US10807986, Example 151 | US1104669...)
Affinity DataIC50: 0.300nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET (V804L or V804M) (i.e., RET with V804L or V804M mut...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311700(Ex. Cpd. 152 | US10807986, Example 152 | US1104669...)
Affinity DataIC50: 0.300nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311622(Ex. Cpd. 59 | US10807986, Example 59 | US11046696,...)
Affinity DataIC50: 0.300nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM577049(US11472802, Example 55)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311705(Ex. Cpd. 157 | US10807986, Example 157 | US1104669...)
Affinity DataIC50: 0.300nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311643(Ex. Cpd. 95 | US10807986, Example 95 | US11046696,...)
Affinity DataIC50: 0.300nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311639(Ex. Cpd. 91 | US10807986, Example 91 | US11046696,...)
Affinity DataIC50: 0.300nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311699(Ex. Cpd. 151 | US10807986, Example 151 | US1104669...)
Affinity DataIC50: 0.300nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311717(Ex. Cpd. 169 | US10807986, Example 169 | US1104669...)
Affinity DataIC50: 0.300nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311634(Ex. Cpd. 86 | US10807986, Example 86 | US11046696,...)
Affinity DataIC50: 0.300nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311651(Ex. Cpd. 103 | US10807986, Example 103 | US1104669...)
Affinity DataIC50: 0.300nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM701994(4-(6-(6-((6-(methoxy-d3)pyridin-3-yl)methyl)-3,6-d...)
Affinity DataIC50: 0.330nMMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM701996(4-(6-(6-((6-(methoxy-d3)pyridin-3-yl)methyl-d2)-3,...)
Affinity DataIC50: 0.360nMMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM311636(Ex. Cpd. 88 | US10807986, Example 88 | US11046696,...)
Affinity DataIC50: 0.400nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM577063(1-(3-(4-amino-7-chloro-1- isopropyl-1H-pyrazolo[4,...)
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM576996(US11472802, Example 11)
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311723(Ex. Cpd. 175 | US10807986, Example 175 | US1104669...)
Affinity DataIC50: 0.400nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311652(Ex. Cpd. 104 | US10807986, Example 104 | US1104669...)
Affinity DataIC50: 0.400nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311653(Ex. Cpd. 105 | US10807986, Example 105 | US1104669...)
Affinity DataIC50: 0.400nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311679(Ex. Cpd. 131 | US10807986, Example 131 | US1104669...)
Affinity DataIC50: 0.5nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311704(Ex. Cpd. 156 | US10807986, Example 156 | US1104669...)
Affinity DataIC50: 0.5nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311707(Ex. Cpd. 159 | US10807986, Example 159 | US1104669...)
Affinity DataIC50: 0.5nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM577064(US11472802, Example 68)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311703(Ex. Cpd. 155 | US10807986, Example 155 | US1104669...)
Affinity DataIC50: 0.5nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM508562(US11046696, Compound 112)
Affinity DataIC50: 0.5nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311700(Ex. Cpd. 152 | US10807986, Example 152 | US1104669...)
Affinity DataIC50: 0.600nMAssay Description:RET (V804M) (i.e., RET with V804M mutation) kinase activity was measured using purified recombinant human RET (V804M) protein purchased from Eurofins...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311700(Ex. Cpd. 152 | US10807986, Example 152 | US1104669...)
Affinity DataIC50: 0.600nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET (V804L or V804M) (i.e., RET with V804L or V804M mut...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311741(Ex. Cpd. 193 | US10807986, Example 193 | US1104669...)
Affinity DataIC50: 0.600nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM469423(US10807986, Example 89 | US11046696, Compound 89)
Affinity DataIC50: 0.600nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311673(Ex. Cpd. 125 | US10807986, Example 125 | US1104669...)
Affinity DataIC50: 0.600nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311691(Ex. Cpd. 143 | US10807986, Example 143 | US1104669...)
Affinity DataIC50: 0.600nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM311635(Ex. Cpd. 87 | US10807986, Example 87 | US11046696,...)
Affinity DataIC50: 0.600nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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