Compile Data Set for Download or QSAR
Report error Found 1329 Enz. Inhib. hit(s) with Target = 'Proteinase-activated receptor 1'
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50077762(Benzofuran-2-carboxylic acid {(S)-1-[(S)-1-((S)-1-...)
Affinity DataEC50:  1.25E+4nMAssay Description:Inhibition of [3H]S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50077754((S)-2-[(S)-3-Cyclohexyl-2-((E)-3-pyridin-3-yl-acry...)
Affinity DataEC50:  2.60E+3nMAssay Description:Inhibition of [3H]S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50077771(5-[(E)-3-(4-Methoxy-phenyl)-acryloylamino]-1H-[1,2...)
Affinity DataEC50:  5.60E+3nMAssay Description:Inhibition of [3H]S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50077721(5-[(E)-3-(4-Trifluoromethyl-phenyl)-acryloylamino]...)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of [3H]S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50077723(5-[(E)-3-(4-Chloro-phenyl)-acryloylamino]-1H-[1,2,...)
Affinity DataEC50:  5.50E+4nMAssay Description:Inhibition of [3H]S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50077729(Pyridine-2-carboxylic acid {(S)-1-[(S)-1-((S)-1-ca...)
Affinity DataEC50:  1.40E+4nMAssay Description:Inhibition of [3H]S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50077718(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid ((S)-...)
Affinity DataEC50:  9.70E+3nMAssay Description:Inhibition of [3H]S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50077763(5-((E)-3-Thiophen-2-yl-acryloylamino)-1H-[1,2,4]tr...)
Affinity DataEC50:  2.90E+3nMAssay Description:Inhibition of [3H]S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50454438(CHEMBL2370948)
Affinity DataEC50:  720nMAssay Description:Effective concentration for stimulation of platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031431((S)-2-[(S)-2-(3-Amino-propionylamino)-3-phenyl-pro...)
Affinity DataEC50:  1.17E+4nMAssay Description:Effective concentration for stimulation of platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50054870(1H-Indole-2-carboxylic acid [1-[1-[1-(1-carbamoyl-...)
Affinity DataEC50:  1.80E+3nMAssay Description:Effective concentration for stimulation of platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50454448(CHEMBL2370955)
Affinity DataEC50:  1.10E+5nMAssay Description:Effective concentration for stimulation of platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031406((S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-propionyla...)
Affinity DataEC50:  160nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031398((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-(3,4-d...)
Affinity DataEC50:  300nMAssay Description:Evaluated for the activity of Radio-ligand Peptides upon the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031386((S)-2-{(S)-2-[(S)-2-[(S)-2-((S)-2-Amino-propionyla...)
Affinity DataEC50:  1.50E+3nMAssay Description:Evaluated for the activity of Radio-ligand Peptides upon the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031377(SFLLRDPQDKYEPF-OH | CHEMBL407378)
Affinity DataEC50:  1.03E+4nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031378((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-pentaf...)
Affinity DataEC50:  6.00E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031379(Ac-SFLLRDPQDK-NH2 | CHEMBL415138)
Affinity DataEC50: >8.00E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031382((S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-propionyla...)
Affinity DataEC50:  120nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031381((S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino...)
Affinity DataEC50:  1.00E+3nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031380((S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-propionyla...)
Affinity DataEC50:  150nMAssay Description:Evaluated for the activity of Radio-ligand Peptides upon the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031383((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-cycloh...)
Affinity DataEC50:  2.80E+4nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031385((S)-2-[(S)-3-(4-Aminomethyl-phenyl)-2-((S)-2-amino...)
Affinity DataEC50:  8.00E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031384(FLLRDPQDK-NH2 | CHEMBL406548)
Affinity DataEC50: >8.00E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031387((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-4-phenyl...)
Affinity DataEC50: >8.00E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031388((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-phenyl...)
Affinity DataEC50:  2.60E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031389((S)-2-{(S)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataEC50:  4.00E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031391((S)-4-Methyl-2-[(S)-2-((S)-2-methylamino-propionyl...)
Affinity DataEC50:  6.00E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031390((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3...)
Affinity DataEC50:  8.00E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031392((S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-h...)
Affinity DataEC50:  200nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031393((S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino...)
Affinity DataEC50:  1.09E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031394((S)-2-{(S)-2-[((S)-2-Amino-3-hydroxy-propionyl)-me...)
Affinity DataEC50: >8.00E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031395(SFLLRDPQDK-OH | CHEMBL268064)
Affinity DataEC50:  8.00E+3nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031398((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-(3,4-d...)
Affinity DataEC50:  270nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031399((S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino...)
Affinity DataEC50:  1.50E+4nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031396((S)-2-[(S)-2-(4-Amino-butyrylamino)-3-phenyl-propi...)
Affinity DataEC50:  7.30E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031397((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-(3,4-d...)
Affinity DataEC50:  500nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031401((S)-2-[(S)-2-(2-Amino-acetylamino)-3-phenyl-propio...)
Affinity DataEC50:  1.20E+3nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031400((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-2-phenyl...)
Affinity DataEC50: >8.00E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031404((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propion...)
Affinity DataEC50:  1.85E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031403((S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino...)
Affinity DataEC50:  7.00E+4nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031405((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propion...)
Affinity DataEC50:  1.30E+3nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031402((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-(4-met...)
Affinity DataEC50:  2.14E+4nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031409((S)-2-{[(S)-2-((S)-2-Amino-3-hydroxy-propionylamin...)
Affinity DataEC50:  3.50E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031408((S)-2-[(S)-3-(4-Amino-phenyl)-2-((S)-2-amino-propi...)
Affinity DataEC50:  2.35E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031407((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-(4-chl...)
Affinity DataEC50:  700nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031386((S)-2-{(S)-2-[(S)-2-[(S)-2-((S)-2-Amino-propionyla...)
Affinity DataEC50:  10nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031412((S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino...)
Affinity DataEC50: >8.00E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031410((S)-2-((S)-2-Amino-3-phenyl-propionylamino)-4-meth...)
Affinity DataEC50: >8.00E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProteinase-activated receptor 1(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031411((S)-3-Amino-N-((S)-1-{(S)-1-[(S)-1-((S)-1-carbamoy...)
Affinity DataEC50: >8.00E+5nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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