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Report error Found 3114 Enz. Inhib. hit(s) with Target = 'Protein mono-ADP-ribosyltransferase TIPARP'
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataKd:  0.220nMAssay Description:Binding affinity to PARP7 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629202(CHEMBL5409458)
Affinity DataEC50:  61nMAssay Description:Inhibition of PARP7 in human NCI-H1373 cells assessed as increase in STAT1 phosphorylation at Tyr701 residue incubated for 48 hrs by LANCE Ultra TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629203(CHEMBL5417113)
Affinity DataEC50:  129nMAssay Description:Inhibition of PARP7 in human NCI-H1373 cells assessed as increase in STAT1 phosphorylation at Tyr701 residue incubated for 48 hrs by LANCE Ultra TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629204(CHEMBL5425262)
Affinity DataEC50:  72nMAssay Description:Inhibition of PARP7 in human NCI-H1373 cells assessed as increase in STAT1 phosphorylation at Tyr701 residue incubated for 48 hrs by LANCE Ultra TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629205(CHEMBL5394931)
Affinity DataEC50:  21nMAssay Description:Inhibition of PARP7 in human NCI-H1373 cells assessed as increase in STAT1 phosphorylation at Tyr701 residue incubated for 48 hrs by LANCE Ultra TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629206(CHEMBL5419793)
Affinity DataEC50:  9.30nMAssay Description:Inhibition of PARP7 in human NCI-H1373 cells assessed as increase in STAT1 phosphorylation at Tyr701 residue incubated for 48 hrs by LANCE Ultra TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM694612(CHEMBL5407196 | US20240294509, Compound 22)
Affinity DataEC50:  172nMAssay Description:Inhibition of PARP7 in human NCI-H1373 cells assessed as increase in STAT1 phosphorylation at Tyr701 residue incubated for 48 hrs by LANCE Ultra TR-F...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629208(CHEMBL5409582)
Affinity DataEC50:  76nMAssay Description:Inhibition of PARP7 in human NCI-H1373 cells assessed as increase in STAT1 phosphorylation at Tyr701 residue incubated for 48 hrs by LANCE Ultra TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629209(CHEMBL5415829)
Affinity DataEC50:  52nMAssay Description:Inhibition of PARP7 in human NCI-H1373 cells assessed as increase in STAT1 phosphorylation at Tyr701 residue incubated for 48 hrs by LANCE Ultra TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629210(CHEMBL5413717)
Affinity DataEC50:  74nMAssay Description:Inhibition of PARP7 in human NCI-H1373 cells assessed as increase in STAT1 phosphorylation at Tyr701 residue incubated for 48 hrs by LANCE Ultra TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629211(CHEMBL5422627)
Affinity DataEC50:  179nMAssay Description:Inhibition of PARP7 in human NCI-H1373 cells assessed as increase in STAT1 phosphorylation at Tyr701 residue incubated for 48 hrs by LANCE Ultra TR-F...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50634478(CHEMBL5400567)
Affinity DataIC50: 0.110nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by incubation with probe for 1.5 hrs by MSD e...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50634483(CHEMBL5397180)
Affinity DataIC50: 0.140nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by incubation with probe for 1.5 hrs by MSD e...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629205(CHEMBL5394931)
Affinity DataIC50: 0.141nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629210(CHEMBL5413717)
Affinity DataIC50: 0.151nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50634482(CHEMBL5393845)
Affinity DataIC50: 0.179nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by incubation with probe for 1.5 hrs by MSD e...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629209(CHEMBL5415829)
Affinity DataIC50: 0.179nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50634481(CHEMBL5422715)
Affinity DataIC50: 0.185nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by incubation with probe for 1.5 hrs by MSD e...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50634479(CHEMBL5407242)
Affinity DataIC50: 0.188nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by incubation with probe for 1.5 hrs by MSD e...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50634480(CHEMBL5421106)
Affinity DataIC50: 0.188nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by incubation with probe for 1.5 hrs by MSD e...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701363((S)-1-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridi...)
Affinity DataIC50: 0.190nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50630273(CHEMBL5403305)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of human recombinant N-terminal FLAG-tagged PARP7 (400 to 657(end) residues) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629206(CHEMBL5419793)
Affinity DataIC50: 0.212nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629211(CHEMBL5422627)
Affinity DataIC50: 0.232nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629208(CHEMBL5409582)
Affinity DataIC50: 0.233nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701389(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.240nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629204(CHEMBL5425262)
Affinity DataIC50: 0.263nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629202(CHEMBL5409458)
Affinity DataIC50: 0.288nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701312((R)-(1-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyrid...)
Affinity DataIC50: 0.380nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701379(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.380nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701399(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.390nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50629203(CHEMBL5417113)
Affinity DataIC50: 0.405nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM700584(US20240336629, Compound 88A)
Affinity DataIC50: 0.416nMAssay Description:(1) Each compound to be tested was prepared using gradient dilution method with DMSO and water to obtain a solution with the concentration of 50 nM, ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM700467(US20240336629, Compound 21A)
Affinity DataIC50: 0.424nMAssay Description:(1) Each compound to be tested was prepared using gradient dilution method with DMSO and water to obtain a solution with the concentration of 50 nM, ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701309(N-(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin...)
Affinity DataIC50: 0.440nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM700585(US20240336629, Compound 88B)
Affinity DataIC50: 0.446nMAssay Description:(1) Each compound to be tested was prepared using gradient dilution method with DMSO and water to obtain a solution with the concentration of 50 nM, ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701376(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.460nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701394(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.480nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701397(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.490nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM700590(US20240336629, Compound 91)
Affinity DataIC50: 0.496nMAssay Description:(1) Each compound to be tested was prepared using gradient dilution method with DMSO and water to obtain a solution with the concentration of 50 nM, ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701359((S)-1-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridi...)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701325((S)-1-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridi...)
Affinity DataIC50: 0.520nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701356((S)-1-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridi...)
Affinity DataIC50: 0.520nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701311(US20240351997, Example 35)
Affinity DataIC50: 0.530nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701374(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.530nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701384(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.530nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701391(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.540nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701357((S)-1-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridi...)
Affinity DataIC50: 0.560nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM701370((S)-1-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridi...)
Affinity DataIC50: 0.560nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50595876(CHEMBL5209116 | US20240336629, Compound 2)
Affinity DataIC50: 0.584nMAssay Description:Inhibition of PARP7 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
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