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Report error Found 1162 Enz. Inhib. hit(s) with Target = 'Protein mono-ADP-ribosyltransferase PARP14'
LigandPNGBDBM50397960(CHEMBL2179989)
Affinity DataKd:  7.60E+3nMAssay Description:Binding affinity at human recombinant ARTD8 expressed in Escherichia coli BL21 (DE3) R3 pRARE cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50397961(CHEMBL2179988)
Affinity DataKd:  1.12E+4nMAssay Description:Binding affinity at human recombinant ARTD8 expressed in Escherichia coli BL21 (DE3) R3 pRARE cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50461015(CHEMBL4228040)
Affinity DataKd:  2.10E+3nMAssay Description:Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50461004(CHEMBL4228373)
Affinity DataKd:  1.60E+3nMAssay Description:Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50461017(CHEMBL4229283)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50461018(CHEMBL4228450)
Affinity DataKd:  3.90E+3nMAssay Description:Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50460988(CHEMBL4226482)
Affinity DataKd:  550nMAssay Description:Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50461035(CHEMBL4227531)
Affinity DataKd:  5.20E+3nMAssay Description:Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50461036(CHEMBL4225366)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50461016(CHEMBL4226393)
Affinity DataKd:  860nMAssay Description:Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50461031(CHEMBL4228190)
Affinity DataKd:  1.50E+3nMAssay Description:Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50594269(CHEMBL5187195)
Affinity DataEC50:  2.61E+4nMAssay Description:Inhibition of human PARP14 MD2 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50594270(CHEMBL5201988)
Affinity DataEC50:  2.71E+4nMAssay Description:Inhibition of human PARP14 MD2 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50594269(CHEMBL5187195)
Affinity DataKd:  8.00E+3nMAssay Description:Binding affinity to CM5 sensor chip immobilized human PARP14 MD2 expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant measured ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50594270(CHEMBL5201988)
Affinity DataKd:  1.62E+5nMAssay Description:Binding affinity to CM5 sensor chip immobilized human PARP14 MD2 expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant measured ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50446130(AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to PARP14 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50316226(MK-4827 | (S)-2-(4-(piperidin-3-yl)phenyl)-2H-inda...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to PARP14 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to PARP14 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM434315(US10562891, Example 235 | US11008308, Example 235)
Affinity DataIC50: 3nMAssay Description:Displacement of a biotinylated small molecule probe from human PARP14 catalytic domain incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM434315(US10562891, Example 235 | US11008308, Example 235)
Affinity DataIC50: 3nMAssay Description:Inhibition of PARP14 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM434315(US10562891, Example 235 | US11008308, Example 235)
Affinity DataIC50: 3nMAssay Description:Inhibition of human PARP14 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50594259(CHEMBL5180081)
Affinity DataIC50: 10nMAssay Description:Inhibition of PARP14 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM434254(US10562891, Example 176 | US11008308, Example 176)
Affinity DataIC50: 19nMAssay Description:Inhibition of PARP14 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50594258(CHEMBL5178541)
Affinity DataIC50: 76nMAssay Description:Inhibition of PARP14 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50242631(CHEMBL4068366)
Affinity DataIC50: 160nMAssay Description:Inhibition of full length recombinant His6-tagged PARP14 catalytic domain (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence ba...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50242631(CHEMBL4068366)
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50242631(CHEMBL4068366)
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50242653(CHEMBL4074448)
Affinity DataIC50: 270nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50242653(CHEMBL4074448)
Affinity DataIC50: 275nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM434101(US10562891, Example 23 | US11008308, Example 23)
Affinity DataIC50: 300nMAssay Description:Inhibition of PARP14 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50616441(CHEMBL5404785)
Affinity DataIC50: 300nMAssay Description:Inhibition of N-terminal MBP tagged/C-terminal PARP14 (unknown origin) expressed in Escherichia coli in presence of NAD+ by proximity enhanced assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50594256(CHEMBL5196898)
Affinity DataIC50: 310nMAssay Description:Displacement of [3H]NAD+ from GST-tagged PARP14 (unknown origin) incubated for 210 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50242657(CHEMBL4104938)
Affinity DataIC50: 370nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50242657(CHEMBL4104938)
Affinity DataIC50: 372nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50242661(CHEMBL4079213)
Affinity DataIC50: 407nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50242661(CHEMBL4079213)
Affinity DataIC50: 410nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50242654(CHEMBL4104503)
Affinity DataIC50: 447nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50242654(CHEMBL4104503)
Affinity DataIC50: 450nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50594244(CHEMBL5205408)
Affinity DataIC50: 490nMAssay Description:Inhibition of PARP14 (unknown origin) expressed in bacterial expression system using histone substrate incubated for 60 mins by chemiluminescence ass...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50594255(CHEMBL5199759)
Affinity DataIC50: 580nMAssay Description:Displacement of [3H]NAD+ from GST-tagged PARP14 (unknown origin) incubated for 210 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50594257(CHEMBL5191979)
Affinity DataIC50: 610nMAssay Description:Inhibition of PARP14 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50468597(CHEMBL4293771)
Affinity DataIC50: 630nMAssay Description:Inhibition of PARP14 (unknown origin) using NAD+ as substrate incubated for 18 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50242655(CHEMBL4080281)
Affinity DataIC50: 650nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50616435(CHEMBL5431108)
Affinity DataIC50: 650nMAssay Description:Inhibition of N-terminal MBP tagged/C-terminal PARP14 (unknown origin) expressed in Escherichia coli in presence of NAD+ by proximity enhanced assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50460988(CHEMBL4226482)
Affinity DataIC50: 660nMAssay Description:Displacement of ARTK(Bio)QTARK(Aoa-RADP)S from His6-tagged PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression sys...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50242655(CHEMBL4080281)
Affinity DataIC50: 676nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50242658(CHEMBL4085694)
Affinity DataIC50: 690nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272968(CHEMBL4126260)
Affinity DataIC50: 692nMAssay Description:Inhibition of full length recombinant His6-tagged human PARP14 WWA/catalytic domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50242658(CHEMBL4085694)
Affinity DataIC50: 692nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50242630(CHEMBL4089522)
Affinity DataIC50: 700nMAssay Description:Inhibition of full length recombinant His6-tagged PARP14 catalytic domain (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence ba...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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