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Report error Found 364 Enz. Inhib. hit(s) with Target = 'Protein mono-ADP-ribosyltransferase PARP10'
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50503853(CHEMBL4545565)
Affinity DataEC50:  1.10E+4nMAssay Description:Inhibition of GFP-tagged human PARP10 expressed in HEK293T cells assessed as reduction in auto-MARylation after 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50503853(CHEMBL4545565)
Affinity DataEC50:  2.30E+3nMAssay Description:Inhibition of GFP-tagged human PARP10 expressed in HEK293T cells assessed as reduction in high molecular weight target protein MARylation after 3 hrs...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataKd:  9.70E+3nMAssay Description:Binding affinity to PARP10 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50446130(AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...)
Affinity DataKd:  3.10E+3nMAssay Description:Binding affinity to PARP10 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50316226(MK-4827 | (S)-2-(4-(piperidin-3-yl)phenyl)-2H-inda...)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to PARP10 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataKd:  5.70E+3nMAssay Description:Binding affinity to PARP10 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM209932(Veliparib | 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-be...)
Affinity DataKd:  6.80E+3nMAssay Description:Binding affinity to PARP10 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM553940(US11325906, Example 4)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to PARP10 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50616441(CHEMBL5404785)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of N-terminal MBP tagged/C-terminal PARP10 (unknown origin) expressed in Escherichia coli in presence of NAD+ by proximity enhanced assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50628429(CHEMBL5402698)
Affinity DataIC50: 11nMAssay Description:Inhibition of PARP10 (unknown origin) using biotinylated NAD+ as substrate by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50616435(CHEMBL5431108)
Affinity DataIC50: 25nMAssay Description:Inhibition of N-terminal MBP tagged/C-terminal PARP10 (unknown origin) expressed in Escherichia coli in presence of NAD+ by proximity enhanced assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50616441(CHEMBL5404785)
Affinity DataIC50: 120nMAssay Description:Inhibition of N-terminal MBP tagged/C-terminal PARP10 (unknown origin) expressed in Escherichia coli in presence of NAD+More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50594006(CHEMBL5192839)
Affinity DataIC50: 130nMAssay Description:Inhibition of human PARP-10 using NAD+ as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50594005(CHEMBL5181947)
Affinity DataIC50: 135nMAssay Description:Inhibition of human PARP-10 using NAD+ as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50594006(CHEMBL5192839)
Affinity DataIC50: 135nMAssay Description:Inhibition of human PARP-10 using NAD+ as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50594005(CHEMBL5181947)
Affinity DataIC50: 140nMAssay Description:Inhibition of human PARP-10 using NAD+ as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50594028(CHEMBL5176874)
Affinity DataIC50: 140nMAssay Description:Inhibition of PARP-10 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50594010(CHEMBL5200358)
Affinity DataIC50: 150nMAssay Description:Inhibition of human PARP-10 using NAD+ as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50594010(CHEMBL5200358)
Affinity DataIC50: 151nMAssay Description:Inhibition of human PARP-10 using NAD+ as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50594007(CHEMBL5187187)
Affinity DataIC50: 155nMAssay Description:Inhibition of human PARP-10 using NAD+ as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50594250(CHEMBL5207717)
Affinity DataIC50: 156nMAssay Description:Inhibition of PARP10 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50594011(CHEMBL5200521)
Affinity DataIC50: 158nMAssay Description:Inhibition of human PARP-10 using NAD+ as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50594007(CHEMBL5187187)
Affinity DataIC50: 160nMAssay Description:Inhibition of human PARP-10 using NAD+ as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50594011(CHEMBL5200521)
Affinity DataIC50: 160nMAssay Description:Inhibition of human PARP-10 using NAD+ as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50468579(CHEMBL4287262)
Affinity DataIC50: 180nMAssay Description:Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50616435(CHEMBL5431108)
Affinity DataIC50: 180nMAssay Description:Inhibition of N-terminal MBP tagged/C-terminal PARP10 (unknown origin) expressed in Escherichia coli in presence of NAD+More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50468579(CHEMBL4287262)
Affinity DataIC50: 186nMAssay Description:Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50452662(CHEMBL4208737)
Affinity DataIC50: 230nMAssay Description:Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50452662(CHEMBL4208737)
Affinity DataIC50: 234nMAssay Description:Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50272953(CHEMBL4128574)
Affinity DataIC50: 245nMAssay Description:Inhibition of full length recombinant His6-tagged human PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50272953(CHEMBL4128574)
Affinity DataIC50: 250nMAssay Description:Inhibition of full length recombinant His6-tagged human PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50593992(CHEMBL5186967)
Affinity DataIC50: 288nMAssay Description:Inhibition of human PARP-10 using NAD+ as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50593992(CHEMBL5186967)
Affinity DataIC50: 290nMAssay Description:Inhibition of human PARP-10 using NAD+ as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50594008(CHEMBL5181107)
Affinity DataIC50: 309nMAssay Description:Inhibition of human PARP-10 using NAD+ as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50594008(CHEMBL5181107)
Affinity DataIC50: 310nMAssay Description:Inhibition of human PARP-10 using NAD+ as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50616432(CHEMBL5421878)
Affinity DataIC50: 320nMAssay Description:Inhibition of N-terminal MBP tagged/C-terminal PARP10 (unknown origin) expressed in Escherichia coli in presence of NAD+More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50616243(CHEMBL5395820)
Affinity DataIC50: 325nMAssay Description:Inhibition of human recombinant N-terminal FLAG-tagged / C-terminal Strep-tagged PARP10 (805 to 1025 end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM199181(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Affinity DataIC50: 329nMAssay Description:This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM199181(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Affinity DataIC50: 329nMAssay Description:Inhibition of full length recombinant His6-tagged PARP10 catalytic domain (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence ba...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM199181(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Affinity DataIC50: 330nMAssay Description:Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM199181(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Affinity DataIC50: 330nMAssay Description:Inhibition of human 6His-tagged PARP10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) cells by fluorescent based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM199181(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Affinity DataIC50: 330nMAssay Description:Inhibition of PARP10 (unknown origin) expressed in Escherichia coli Rosette2 (DE3)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 350nMAssay Description:Inhibition of human N-terminal FLAG-tagged/C-terminal Strep-tagged recombinant PARP10 (805 to 1025 residues) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50272959(CHEMBL4125748)
Affinity DataIC50: 387nMAssay Description:Inhibition of full length recombinant His6-tagged human PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50272959(CHEMBL4125748)
Affinity DataIC50: 390nMAssay Description:Inhibition of full length recombinant His6-tagged human PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50272966(CHEMBL4129789)
Affinity DataIC50: 398nMAssay Description:Inhibition of full length recombinant His6-tagged human PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50272966(CHEMBL4129789)
Affinity DataIC50: 400nMAssay Description:Inhibition of full length recombinant His6-tagged human PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50272957(CHEMBL4127497)
Affinity DataIC50: 457nMAssay Description:Inhibition of full length recombinant His6-tagged human PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50272957(CHEMBL4127497)
Affinity DataIC50: 460nMAssay Description:Inhibition of full length recombinant His6-tagged human PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50272950(CHEMBL4130035)
Affinity DataIC50: 460nMAssay Description:Inhibition of full length recombinant His6-tagged human PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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