Compile Data Set for Download or QSAR
Report error Found 183 Enz. Inhib. hit(s) with Target = 'Protein kinase C iota type'
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human PKCiota using ERMRPRKRQGSVRRRV as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455611(CHEMBL4212424)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455569(CHEMBL4202753)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455593(CHEMBL4208685)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455592(CHEMBL4206065)
Affinity DataIC50: 5nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455602(CHEMBL4216507)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 16.7nMAssay Description:Inhibition of human PKCiota using ERMRPRKRQGSVRRRV as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  26nMAssay Description:Binding constant for PRKCI kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455566(CHEMBL4208028)
Affinity DataIC50: 30nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 31.6nMAssay Description:Inhibition of human PKCiota using ERMRPRKRQGSVRRRV as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50536679(CHEMBL4568087)
Affinity DataIC50: 37nMAssay Description:Inhibition of full-length recombinant human His-tagged PRKCI expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455589(CHEMBL4213984)
Affinity DataIC50: 48nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455594(CHEMBL4212934)
Affinity DataIC50: 65nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50543619(CHEMBL4637651)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant full-length human aPKCiota using CREBtide as substrate incubated for 3 hrs in presence of ATP by kinase Glo luminescent ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455610(CHEMBL4211722)
Affinity DataIC50: 110nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455588(CHEMBL4208982)
Affinity DataIC50: 120nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  174nMAssay Description:Binding affinity to human PRKCI incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)
Affinity DataKd:  250nMAssay Description:Binding constant for PRKCI kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  255nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged PRKCI (unknown origin) expressed in baculovirus infected Sf9 insect cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50526595(CHEMBL4517782)
Affinity DataIC50: 270nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused PKCi (1 to 587 residues) expressed in baculovirus expression system using 5-FAM-RFAR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455568(CHEMBL4215492)
Affinity DataIC50: 290nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  314nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged PRKCI (unknown origin) expressed in baculovirus infected Sf9 insect cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50526582(CHEMBL4471416)
Affinity DataIC50: 340nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused PKCi (1 to 587 residues) expressed in baculovirus expression system using 5-FAM-RFAR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50059889(3-methoxy-2-methyl-4-methylamino-(2S,3S,4S,6R)-29-...)
Affinity DataIC50: 364nMAssay Description:Inhibition of human PKCiotaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455590(CHEMBL4206023)
Affinity DataIC50: 570nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50526584(CHEMBL4441139)
Affinity DataIC50: 710nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused PKCi (1 to 587 residues) expressed in baculovirus expression system using 5-FAM-RFAR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 720nMAssay Description:Inhibition of full-length recombinant human His-tagged PRKCI expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455587(CHEMBL4205851)
Affinity DataIC50: 800nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM139465(US8889672, 317-080-001)
Affinity DataIC50: 900nMAssay Description:Inhibition of atypical PKCiota (unknown origin) using CREBtide as substrate incubated for 1 hr measured every 2.5 mins by ADP Quest assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM139469(US8889672, 317-052-004)
Affinity DataIC50: 900nMAssay Description:Inhibition of atypical PKCiota (unknown origin) using CREBtide as substrate incubated for 1 hr measured every 2.5 mins by ADP Quest assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50192071((13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahe...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PKCiotaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM174948(US9096593, P-2049)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PRKCI (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455564(CHEMBL4211820)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  1.35E+3nMAssay Description:Binding affinity to human PRKCI incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM17055((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...)
Affinity DataKd:  1.40E+3nMAssay Description:Binding constant for PRKCI kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged PRKCI expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  1.80E+3nMAssay Description:Binding constant for PRKCI kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM139467(US8889672, 268-020-002)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of atypical PKCiota (unknown origin) using CREBtide as substrate incubated for 1 hr measured every 2.5 mins by ADP Quest assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM2683(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)
Affinity DataIC50: 3.46E+3nMAssay Description:Inhibition of human PKCiotaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50543619(CHEMBL4637651)
Affinity DataIC50: 4.08E+3nMAssay Description:Inhibition of recombinant full-length human aPKCiota in presence of ATP at Km concentration by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455570(CHEMBL4214431)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM139464(US8889672, 194-074-007 | US8889672, PKCzI-diMeO)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of atypical PKCiota (unknown origin) using CREBtide as substrate incubated for 1 hr measured every 2.5 mins by ADP Quest assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50355500(CHEMBL1908394 | US9695172, GSK461364)
Affinity DataKd:  5.80E+3nMAssay Description:Binding constant for PRKCI kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455585(CHEMBL4217980)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50536678(CHEMBL4550702)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged PRKCI expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455627(CHEMBL4215555)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455586(CHEMBL4214403)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455584(CHEMBL4216980)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50455620(CHEMBL4208713)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PRKCI kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
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