Compile Data Set for Download or QSAR
Report error Found 1994 Enz. Inhib. hit(s) with Target = 'Protein kinase C alpha type'
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM92594(Phorbol ester (PDBU))
Affinity DataKd:  3.40nMpH: 7.4 T: 2°CAssay Description:[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50092014(Butyric acid (1aS,1bS,4aS,7aS,8R,9S,9aR)-9-butyryl...)
Affinity DataKd:  0.280nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50258529(CHEMBL449158 | bryostatin 1)
Affinity DataKd:  0.730nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM102423(Bryostatin | Bryostatin 7)
Affinity DataKd:  0.440nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  47nMAssay Description:Displacement of [3H]PDBu from Protein kinase C alpha C1b domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  7.40nMAssay Description:Binding affinity for Protein kinase C alpha C1b domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.10nMAssay Description:Binding affinity for protein kinase C Alpha-C1A domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  0.800nMAssay Description:Dissociation constant for Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50133236(Tetradecanedioic acid ((S)-5-hydroxymethyl-2-isopr...)
Affinity DataKd:  0.280nMAssay Description:Binding affinity for human Protein kinase C alpha with [Ca2+]More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  6.00E+3nMAssay Description:Average Binding Constant for PRKACA; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  50nMAssay Description:Average Binding Constant for PRKACA; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to PKAC-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  720nMAssay Description:Binding affinity to PKAC-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.10nMAssay Description:Inhibition of [3H]PDBu binding to PKC alpha C1A peptideMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50326054(CHEMBL1240703)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to PKAC-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  220nMAssay Description:Binding affinity to PKAC-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to PKAC-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM13535(N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to PKAC-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to PKAC-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50099066(phorbol 13-acetate 12-myristate | CHEMBL279115)
Affinity DataEC50:  1.70E+6nMAssay Description:Binding affinity to recombinant C1 domain of PKCalpha expressed in Escherichia coli BL21 (DE3) after 45 mins by fluorescence quenching assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50351475(CHEMBL1819528)
Affinity DataEC50:  5.04E+6nMAssay Description:Binding affinity to recombinant C1 domain of PKCalpha expressed in Escherichia coli BL21 (DE3) after 45 mins by fluorescence quenching assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM23926(5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol...)
Affinity DataEC50:  5.78E+6nMAssay Description:Binding affinity to recombinant C1 domain of PKCalpha expressed in Escherichia coli BL21 (DE3) after 45 mins by fluorescence quenching assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM23928(CHEMBL296411 | 1,3-dimethoxy-5-[(E)-2-(4-methoxyph...)
Affinity DataEC50:  1.56E+6nMAssay Description:Binding affinity to recombinant C1 domain of PKCalpha expressed in Escherichia coli BL21 (DE3) after 45 mins by fluorescence quenching assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50351474(CHEMBL1819531)
Affinity DataEC50:  2.98E+6nMAssay Description:Binding affinity to recombinant C1 domain of PKCalpha expressed in Escherichia coli BL21 (DE3) after 45 mins by fluorescence quenching assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.10nMAssay Description:Binding affinity to PKCalpha-C1A domain peptide using [3H]-labeled compoundMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  0.280nMAssay Description:Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCalpha (unknown origin) in presence of 100 ug/ml 100% phosphatidylserineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.40nMAssay Description:Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCalpha (unknown origin) in presence of nuclear membrane mimetic lipid mixtureMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataKd:  6.40nMAssay Description:Binding affinity to PKCalpha (unknown origin) using Lys-Arg-Thr-Leu-Arg-Arg as substrate after 8 mins in presence of [gamma-32P]ATP by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  7.40nMAssay Description:Binding affinity for protein kinase C Alpha-C1B domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.10nMAssay Description:Binding affinity for Protein kinase C alpha C1a domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  43nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged PRKCA (unknown origin) expressed in baculovirus infected Sf9 insect cells ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  92nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged PRKCA (unknown origin) expressed in baculovirus infected Sf9 insect cells ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 0.0740nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM251455(US9452998, 4)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM251458(US9452998, 7)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM251491(US9452998, 51 | US9452998, 40)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM251496(US9452998, 45)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM251497(US9452998, 46)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM251506(US9452998, 55)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM251507(US9452998, 76 | US9452998, 56)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM251508(US9452998, 57)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM251509(US9452998, 58)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM251512(US9452998, 61)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM251513(US9452998, 62)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM251515(US9452998, 64)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM251516(US9452998, 65)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM251517(US9452998, 77 | US9452998, 66)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM251522(US9452998, 71)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM251523(US9452998, 78 | US9452998, 72)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM251524(US9452998, 73)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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