Compile Data Set for Download or QSAR
Report error Found 2094 Enz. Inhib. hit(s) with Target = 'Protein kinase C alpha type'
TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50128285(3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmet...)
Affinity DataIC50: 0.0390nMAssay Description:Inhibition of recombinant human PKCalpha using myelin basic protein as substrate incubated for 60 mins in presence of 33p-ATP and ATP by microbeta sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 0.0740nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251513(US9452998, 62)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PKCalpha (unknown origin) incubated for 15 mins in presence of 33P-ATP by Topcount scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251522(US9452998, 71)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PKCalpha (unknown origin) incubated for 15 mins in presence of 33P-ATP by Topcount scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50642779(CHEMBL5573642)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PKCalpha (unknown origin) incubated for 15 mins in presence of 33P-ATP by Topcount scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251528(US9452998, 77)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PKCalpha (unknown origin) incubated for 15 mins in presence of 33P-ATP by Topcount scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251508(US9452998, 57)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PKCalpha (unknown origin) incubated for 15 mins in presence of 33P-ATP by Topcount scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251458(US9452998, 7)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251522(US9452998, 71)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251491(US9452998, 51 | US9452998, 40)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251523(US9452998, 78 | US9452998, 72)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251455(US9452998, 4)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251516(US9452998, 65)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251517(US9452998, 77 | US9452998, 66)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251496(US9452998, 45)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251517(US9452998, 77 | US9452998, 66)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251574(US9452998, Table 4 Compound 4)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251497(US9452998, 46)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251523(US9452998, 78 | US9452998, 72)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251572(US9452998, Table 4 Compound 2)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251507(US9452998, 76 | US9452998, 56)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251524(US9452998, 73)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251506(US9452998, 55)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251507(US9452998, 76 | US9452998, 56)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251529(US9452998, 78)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of PKCalpha (unknown origin) incubated for 15 mins in presence of 33P-ATP by Topcount scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251515(US9452998, 64)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251512(US9452998, 61)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251544(US9452998, 93)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251513(US9452998, 62)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251508(US9452998, 57)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251509(US9452998, 58)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM86434(NSC_105100 | CAS_105100 | 12-Deoxyphorbol 13-pheny...)
Affinity DataKi:  0.140nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251511(US9452998, 60)
Affinity DataIC50: 0.140nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50099646(Ingenol-3-bezoate | 5,6-dihydroxy-7-hydroxymethyl-...)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]PDBU from protein kinase C-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251573(US9452998, Table 4 Compound 3)
Affinity DataIC50: 0.150nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251540(US9452998, 89)
Affinity DataIC50: 0.160nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251493(US9452998, 42)
Affinity DataIC50: 0.170nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251501(US9452998, 50)
Affinity DataIC50: 0.190nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251575(US9452998, Table 4 Compound 5)
Affinity DataIC50: 0.190nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Bovine)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKi:  0.200nMAssay Description:Ability to displace bound [20-3H]-PDBU from a recombinant single isozyme (PKCalpha) in the presence of phosphatidylserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251504(US9452998, 53)
Affinity DataIC50: 0.200nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKi:  0.200nMAssay Description:Binding Affinity against protein kinase C alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251491(US9452998, 51 | US9452998, 40)
Affinity DataIC50: 0.200nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251494(US9452998, 43)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PKCalpha (unknown origin) incubated for 15 mins in presence of 33P-ATP by Topcount scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251504(US9452998, 53)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PKCalpha (unknown origin) incubated for 15 mins in presence of 33P-ATP by Topcount scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50642785(CHEMBL5592487)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PKCalpha (unknown origin) incubated for 15 mins in presence of 33P-ATP by Topcount scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251457(US9452998, 6)
Affinity DataIC50: 0.220nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM86429(NSC_6437389 | CAS_6437389 | Thymeleatoxin (low PS)...)
Affinity DataKi:  0.220nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251480(US9452998, 29)
Affinity DataIC50: 0.240nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM251505(US9452998, 54)
Affinity DataIC50: 0.25nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

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