Compile Data Set for Download or QSAR
Report error Found 598 Enz. Inhib. hit(s) with Target = 'Protein Mdm4'
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM6863(US8815926, 101 | US8815926, 295)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of human MDM4 by SRP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50513200(CHEMBL4514512)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of MDMX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50287913(CHEMBL4175039)
Affinity DataKd:  2.30nMAssay Description:Binding affinity to full length human MDM4 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50241617(CHEMBL4068667)
Affinity DataIC50: 3nMAssay Description:Inhibition of MDMX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50241617(CHEMBL4068667)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM63209(SMR000206694 | 3-(1-phenyl-2-thioxo-2,3-dihydro-1H...)
Affinity DataIC50: 3.74nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2011
Entry Details
PCBioAssay
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50241630(CHEMBL4065471)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50241631(CHEMBL4095983)
Affinity DataIC50: 6nMAssay Description:Inhibition of MDMX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50241631(CHEMBL4095983)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50403302(CHEMBL5290323)
Affinity DataKi:  6.80nMAssay Description:Binding affinity to human MDM4 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50624183(CHEMBL5394570)
Affinity DataKd:  6.90nMAssay Description:Binding affinity to 6x-His-TEV-tagged human MDMX (15 to 111 residues) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50624185(CHEMBL5439046)
Affinity DataKd:  7nMAssay Description:Binding affinity to 6x-His-TEV-tagged human MDMX (15 to 111 residues) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50624185(CHEMBL5439046)
Affinity DataKi:  7nMAssay Description:Binding affinity to 6x-His-TEV-tagged human MDMX (15 to 111 residues) assessed as inhibition constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50261656(CHEMBL3347578)
Affinity DataKd:  8.5nMAssay Description:Inhibition of p53 binding to MDMX (unknown origin) after 30 mins by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2020
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50617216(CHEMBL5410760)
Affinity DataIC50: 9nMAssay Description:Inhibition of human MDM4 (1 to 116 residues) incubated for 1 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50241627(CHEMBL4105199)
Affinity DataIC50: 10nMAssay Description:Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50646921(CHEMBL5592260)
Affinity DataKd:  10nMAssay Description:Binding affinity to N-terminal human MDMX (22 to 110 residues) extracted from Escherichia coli BL21 (DE3) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50241621(CHEMBL4095042)
Affinity DataIC50: 11nMAssay Description:Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50287990(CHEMBL4165669)
Affinity DataIC50: 12nMAssay Description:Displacement of p53 from MDM4 in human SHSY-5Y cells incubated for 10 mins by sandwich ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50624186(CHEMBL5408686)
Affinity DataKi:  13nMAssay Description:Binding affinity to 6x-His-TEV-tagged human MDMX (15 to 111 residues) assessed as inhibition constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50403306(CHEMBL5271788)
Affinity DataKd:  13nMAssay Description:Binding affinity to human MDM4 assessed as dissociation constant by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50605104(CHEMBL5180980)
Affinity DataIC50: 17nMAssay Description:Inhibition of human MDM4 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50403528(CHEMBL5280843)
Affinity DataIC50: 17nMAssay Description:Inhibition of human MDM4 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50403525(CHEMBL3220312)
Affinity DataIC50: 17nMAssay Description:Inhibition of MDMX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50590815(CHEMBL5199785)
Affinity DataIC50: 18nMAssay Description:Inhibition of MDM4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50261657(CHEMBL4075572)
Affinity DataKd:  19nMAssay Description:Inhibition of p53 binding to MDMX (unknown origin) after 30 mins by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2020
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50605104(CHEMBL5180980)
Affinity DataKd:  20nMAssay Description:Binding affinity to MDMX (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50646924(CHEMBL5593446)
Affinity DataIC50: 20nMAssay Description:Inhibition of MDMX (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50646930(CHEMBL2313487)
Affinity DataIC50: 20nMAssay Description:Inhibition of MDMX (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50261655(CHEMBL4090785)
Affinity DataKd:  21nMAssay Description:Inhibition of p53 binding to MDMX (unknown origin) after 30 mins by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2020
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50241626(CHEMBL4080951)
Affinity DataIC50: 23nMAssay Description:Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50403372(CHEMBL5286157)
Affinity DataKi:  25nMAssay Description:Binding affinity to human MDM4 assessed as inhibition constant by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50403525(CHEMBL3220312)
Affinity DataIC50: 25nMAssay Description:Inhibition of MDM4 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50403525(CHEMBL3220312)
Affinity DataIC50: 25nMAssay Description:Inhibition of human MDM4More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50590813(CHEMBL5204846)
Affinity DataIC50: 25nMAssay Description:Inhibition of MDM4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50403367(CHEMBL5283428)
Affinity DataKd:  25nMAssay Description:Binding affinity to human MDM4 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50590814(CHEMBL5182359)
Affinity DataKd:  27nMAssay Description:Binding affinity to N-terminal TEV/GST-fused human MDM4 (22 to 110 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation consta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50403527(CHEMBL5280949)
Affinity DataKd:  27nMAssay Description:Inhibition of human his-tagged MDM4 assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50590814(CHEMBL5182359)
Affinity DataIC50: 27nMAssay Description:Inhibition of MDM4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50631476(CHEMBL5440363)
Affinity DataKi: >27nMAssay Description:Inhibition of MDM4 (14 to 111 residues)/p53 (unknown origin) interaction expressed in Escherichia coli BL21(DE3) cells assessed as inhibition constan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50646934(CHEMBL5593847)
Affinity DataIC50: 30nMAssay Description:Inhibition of MDMX (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50629225(CHEMBL5414695)
Affinity DataIC50: 30nMAssay Description:Inhibition of N-terminal biotin-his-tagged MDMX (24 to 108 residues)(unknown origin) binding to p53 incubated for 1 hr by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50646929(CHEMBL2313485)
Affinity DataIC50: 40nMAssay Description:Inhibition of MDMX (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50261656(CHEMBL3347578)
Affinity DataIC50: 40nMAssay Description:Inhibition of human MDM4 by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50403482(CHEMBL5267044)
Affinity DataIC50: 41nMAssay Description:Inhibition of human MDM4More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50403482(CHEMBL5267044)
Affinity DataIC50: 41nMAssay Description:Inhibition of MDMX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50403367(CHEMBL5283428)
Affinity DataKd:  43nMAssay Description:Binding affinity to human MDM4 assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50617215(CHEMBL5395151)
Affinity DataIC50: 43nMAssay Description:Inhibition of human MDM4 (1 to 116 residues) incubated for 1 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50241618(CHEMBL4064911)
Affinity DataIC50: 56nMAssay Description:Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50624184(CHEMBL5415331)
Affinity DataKd:  57nMAssay Description:Binding affinity to 6x-His-TEV-tagged human MDMX (15 to 111 residues) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
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