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Report error Found 8283 Enz. Inhib. hit(s) with Target = 'Prostaglandin G/H synthase 1' Sort by
LigandPNGBDBM50486822(CHEBI:76249 | Miroprofen)
Affinity DataKd:  185nMAssay Description:Binding affinity to COX1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50486823(CHEMBL2235866)
Affinity DataKd:  262nMAssay Description:Binding affinity to COX1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50486824(CHEMBL2235864)
Affinity DataKd:  1.04E+3nMAssay Description:Binding affinity to COX1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataKd:  253nMAssay Description:Binding affinity to COX1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50427217(CHEMBL2324850)
Affinity DataKd:  1.54E+3nMAssay Description:Binding affinity to COX1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50486825(CHEMBL2235865)
Affinity DataKd:  16nMAssay Description:Binding affinity to COX1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human recombinant COX1 using arachidonic acid as substrate measured after 3 mins by ADHP reagent based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Pennsylvania School of Medicine

Curated by ChEMBL
LigandPNGBDBM23417(cid_72276 | (-)-Epicatechin | (2R,3R)-2-(3,4-dihyd...)
Affinity DataKd:  2.59E+4nMAssay Description:Binding affinity to COX1 in sheep seminal vesicleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Pennsylvania School of Medicine

Curated by ChEMBL
LigandPNGBDBM26189(CHEMBL24147 | benzene-1,3-diol | 1,3-dihydroxybenz...)
Affinity DataKd:  8.69E+4nMAssay Description:Binding affinity to COX1 in sheep seminal vesicleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Pennsylvania School of Medicine

Curated by ChEMBL
LigandPNGBDBM50236527((-)-catechin | (2S,3R)-2-(3,4-dihydroxyphenyl)-3,4...)
Affinity DataKd:  4.87E+4nMAssay Description:Binding affinity to COX1 in sheep seminal vesicleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Pennsylvania School of Medicine

Curated by ChEMBL
LigandPNGBDBM50135167(Epicatechin | (-) epicatechine | (2S,3S)-2-(3,4-Di...)
Affinity DataKd:  2.51E+4nMAssay Description:Binding affinity to COX1 in sheep seminal vesicleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Pennsylvania School of Medicine

Curated by ChEMBL
LigandPNGBDBM23926(5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol...)
Affinity DataKd:  1.17E+4nMAssay Description:Binding affinity to COX1 in sheep seminal vesicleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Pennsylvania School of Medicine

Curated by ChEMBL
LigandPNGBDBM23416((+)-Catechin | CHEMBL311498 | (2R,3S)-2-(3,4-dihyd...)
Affinity DataKd:  4.07E+4nMAssay Description:Binding affinity to COX1 in sheep seminal vesicleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Pennsylvania School of Medicine

Curated by ChEMBL
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50: 0.0100nMAssay Description:COX activity was measured using a commercial kit (COX Inhibitor Screening Assay Kit Cayman Chemical N. 560131) which includes both ovine COX-1 and hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2019
Entry Details
Go to US Patent

LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Pennsylvania School of Medicine

Curated by ChEMBL
LigandPNGBDBM50153360(CHEMBL3774784)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of ovine COX1 assessed as production of PGF2-alpha preincubated with compound followed by the addition of 5 uM arachidonic acid as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Bovine)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50247597(4,5-Bis(4-methoxyphenyl)-3H-1,2-dithiol-3-one | CH...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 0.700nMAssay Description:Tested for inhibition against Prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Pennsylvania School of Medicine

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate incubated for 5 mins by colorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Pennsylvania School of Medicine

Curated by ChEMBL
LigandPNGBDBM50269230(N,N-Dimethyl-12-(R-valinoyl)-13-acetyl-4alpha-4-de...)
Affinity DataIC50: 1nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Pennsylvania School of Medicine

Curated by ChEMBL
LigandPNGBDBM50269236(3 beta-O-acetyloleanolic acid | CHEMBL503071)
Affinity DataIC50: 1nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Pennsylvania School of Medicine

Curated by ChEMBL
LigandPNGBDBM50269235(12-O-[(2R)-N,N-dimethyl-3-methylbutanoyl]phorbol 1...)
Affinity DataIC50: 1nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Pennsylvania School of Medicine

Curated by ChEMBL
LigandPNGBDBM50219329(CHEMBL8968)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity (RA1) against Prostaglandin G/H synthase 1 was calculated relative to aspirinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Pennsylvania School of Medicine

Curated by ChEMBL
LigandPNGBDBM50088679(2-Phenyl-isoindole-1,3-dione | 2-phenylisoindoline...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity (RA1) against Prostaglandin G/H synthase 1 was calculated relative to aspirinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Pennsylvania School of Medicine

Curated by ChEMBL
LigandPNGBDBM50066441(2-(2,6-Dimethyl-phenyl)-isoindole-1,3-dione | 2-(2...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity (RA1) against Prostaglandin G/H synthase 1 was calculated relative to aspirinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472616(CHEMBL65325)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472618(CHEMBL303092)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472623(CHEMBL294100)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472624(CHEMBL62439)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472627(CHEMBL304489)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472632(CHEMBL65140)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50601852(CHEMBL5206077)
Affinity DataIC50: 1nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50094539(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.1.0*2...)
Affinity DataIC50: 1nMAssay Description:Tested in vitro for inhibition against Prostaglandin G/H synthase 1 in human bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50362901(CHEMBL1945285)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of COX1 in human HEL 92.1.7 cells assessed as thromboxane B2 production incubated for 30 mins before arachidonic acid addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50376383(CHEMBL259972)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM50376383(CHEMBL259972)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Pennsylvania School of Medicine

Curated by ChEMBL
LigandPNGBDBM50376383(CHEMBL259972)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of ovine COX-1 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
LigandPNGBDBM50088570(2-(3-Benzoyl-phenyl)-propionic acid | (S)-2-(3-ben...)
Affinity DataIC50: 1.90nMAssay Description:Concentration required for 50% inhibition against Prostaglandin G/H synthase 1 from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50022271(2-(3-benzoylphenyl)propanoic acid | 2-(3-Benzoylph...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of cyclooxygenase-1 via inhibition of TXB2 generation in the presence of 1 uM arachidonic acid in human plateletMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibitory activity against human Prostaglandin G/H synthase 1 (COX-1) in U-937 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibitory activity against Prostaglandin G/H synthase 1 in murine J774 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50022271(2-(3-benzoylphenyl)propanoic acid | 2-(3-Benzoylph...)
Affinity DataIC50: 2nMAssay Description:Inhibition of COX-1 in human platelet in presence of arachidonic acid by human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM50332752((2R)-6,8-dichloro-7-(2-methylpropoxy)-2-(trifluoro...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50229761(L-689037 | CHEMBL314337)
Affinity DataIC50: 2nMAssay Description:The compound was tested for inhibitory activity against Prostaglandin G/H synthase in human polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472613(CHEMBL305076)
Affinity DataIC50: 2.10nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472605(CHEMBL64507)
Affinity DataIC50: 2.5nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472612(CHEMBL60496)
Affinity DataIC50: 2.5nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 2.90nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 3nMAssay Description:Inhibition of arachidonic acid induced TXB2 generation in isolated human platelets (Prostaglandin G/H synthase 1 cell assay)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Prostaglandin G/H synthase 1 in U-937 cells from human histiocytic lymphomaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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