Compile Data Set for Download or QSAR
Report error Found 4738 Enz. Inhib. hit(s) with Target = 'Prostaglandin D2 receptor 2'
TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50163943((Z)-7-[(1R,2R,5S)-5-Hydroxy-2-((E)-(S)-3-hydroxy-o...)
Affinity DataEC50:  7nMAssay Description:Effective concentration DP2 mediated expression of the adhesion molecule CD11b in eosinophilsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50163942((Z)-7-[(1R,4S,5R)-5-Hydroxy-2-((R)-3-hydroxy-3-met...)
Affinity DataEC50:  1.40nMAssay Description:Effective concentration DP2 mediated expression of the adhesion molecule CD11b in eosinophilsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50163942((Z)-7-[(1R,4S,5R)-5-Hydroxy-2-((R)-3-hydroxy-3-met...)
Affinity DataEC50:  3.80nMAssay Description:Effective concentration for DP2 mediated stimulation of actin polymerization in eosinophilsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50163943((Z)-7-[(1R,2R,5S)-5-Hydroxy-2-((E)-(S)-3-hydroxy-o...)
Affinity DataEC50:  13nMAssay Description:Effective concentration for DP2 mediated stimulation of actin polymerization in eosinophilsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50410150(CHEMBL2096774)
Affinity DataEC50:  128nMAssay Description:Effective concentration for DP2 mediated chemotaxis in eosinophilsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50410150(CHEMBL2096774)
Affinity DataEC50:  99nMAssay Description:Effective concentration DP2 mediated expression of the adhesion molecule CD11b in eosinophilsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50163942((Z)-7-[(1R,4S,5R)-5-Hydroxy-2-((R)-3-hydroxy-3-met...)
Affinity DataEC50:  1.70nMAssay Description:Effective concentration for DP2 mediated chemotaxis in eosinophilsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50163943((Z)-7-[(1R,2R,5S)-5-Hydroxy-2-((E)-(S)-3-hydroxy-o...)
Affinity DataEC50:  10nMAssay Description:Effective concentration for DP2 mediated chemotaxis in eosinophilsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50312283((+/-)-cis-N-(1-benzoyl-2-methyl-1,2,3,4-tetrahydro...)
Affinity DataEC50:  11nMAssay Description:Antagonist activity at human CRTH2 receptor expressed in CEM cell assessed as inhibition of PGD2-induced cell migration after 3 hrs by transwell migr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataEC50:  24nMAssay Description:Antagonist activity at CRTH2 in human eosinophils assessed as inhibition of PGD2-induced shape changeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataEC50:  389nMAssay Description:Partial antagonist activity at CRTH2 in human eosinophils assessed as inhibition of PGD2-induced shape change by FACS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50423390(CHEMBL398303 | CHEMBL250675)
Affinity DataKd:  1nMAssay Description:Displacement of [3H]TRQ11238 from human CRTH2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50410150(CHEMBL2096774)
Affinity DataEC50:  333nMAssay Description:Effective concentration for DP2 mediated stimulation of actin polymerization in eosinophilsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM228392(6-Cyano-7-(4-(4-chlorophenylcarbamoyl)phenoxy)chro...)
Affinity DataEC50:  400nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM228392(6-Cyano-7-(4-(4-chlorophenylcarbamoyl)phenoxy)chro...)
Affinity DataEC50:  16.6nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM228398(4-(6-Cyano-4-(methoxycarbonyl)chroman-7-yloxy)benz...)
Affinity DataEC50:  70nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM228402(7-(4-(4-Chlorophenylcarbamoyl)phenoxy)-6-cyano-2,2...)
Affinity DataEC50:  5.00E+3nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM228402(7-(4-(4-Chlorophenylcarbamoyl)phenoxy)-6-cyano-2,2...)
Affinity DataEC50:  129nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM228438(Ethyl 6-chloro-7-hydroxychroman-4-carboxylate | US...)
Affinity DataEC50:  10.7nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230037(6-Cyano-7-(4-(phenethylcarbamoyl)phenoxy)chroman-4...)
Affinity DataEC50:  37.4nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230038(6-Cyano-7-(4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)p...)
Affinity DataEC50:  77.3nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230039(US9556139, 7)
Affinity DataEC50:  19nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230040(2-(4-Chloro-2-methoxyphenyl)ethanamine | US9556139...)
Affinity DataEC50:  16nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230041(2-(2-Methoxy-4-(trifluoromethyl)phenyl)ethanamine ...)
Affinity DataEC50:  203nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230042(6-Chloro-7-(4-(4-chlorophenethylcarbamoyl)phenoxy)...)
Affinity DataEC50:  225nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230042(6-Chloro-7-(4-(4-chlorophenethylcarbamoyl)phenoxy)...)
Affinity DataEC50:  13.9nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230043(US9556139, 11 Enantiomer 2)
Affinity DataEC50:  111nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230043(US9556139, 11 Enantiomer 2)
Affinity DataEC50:  9.30nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230044(Sodium 6-chloro-7-(4-(phenethylcarbamoyl)phenoxy)c...)
Affinity DataEC50:  794nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230045(Sodium 6-chloro-7-(4-(4-phenylbutylcarbamoyl)pheno...)
Affinity DataEC50:  405nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230046(Sodium 6-chloro-7-(4-(4-(3-chlorophenyl)butylcarba...)
Affinity DataEC50:  824nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230047(Sodium 6-chloro-7-(4-(4-(4-chlorophenyl)butylcarba...)
Affinity DataEC50:  746nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230048(Sodium (Z)-6-chloro-7-(4-(4-(2-chlorophenyl)but-3-...)
Affinity DataEC50:  318nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230049(Sodium 6-chloro-7-(4-(4-(2-chlorophenyl)butylcarba...)
Affinity DataEC50:  395nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230050(Sodium (Z)-6-chloro-7-(4-(4-(2,4-dichlorophenyl)bu...)
Affinity DataEC50:  502nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230051(Sodium 6-chloro-7-(4-(4-(2,4-dichlorophenyl)butylc...)
Affinity DataEC50:  638nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230052(Sodium 6-chloro-7-(4-(2-methylphenethylcarbamoyl)p...)
Affinity DataEC50:  759nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230053(Sodium 6-chloro-7-(4-(2,4-dimethylphenethylcarbamo...)
Affinity DataEC50:  169nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230054(Sodium 6-chloro-7-(4-(4-methylphenethylcarbamoyl)p...)
Affinity DataEC50:  438nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230055(Sodium 7-(4-(4-bromophenethylcarbamoyl)phenoxy)-6-...)
Affinity DataEC50:  327nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230056(Sodium 6-chloro-7-(4-(4-cyclopropylphenethylcarbam...)
Affinity DataEC50:  482nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230057(Sodium 6-chloro-7-(4-(2-cyclopropylethylcarbamoyl)...)
Affinity DataEC50:  3.33E+3nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230058(Sodium 6-chloro-7-(4-(2-(2′-chlorobiphenyl-4...)
Affinity DataEC50:  160nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230059(Sodium 6-chloro-7-(4-(4-chloro-2-methylphenethylca...)
Affinity DataEC50:  216nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230060(Sodium 7-(4-(4-bromo-2-chlorophenethylcarbamoyl)ph...)
Affinity DataEC50:  123nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230061(Sodium 6-chloro-7-(4-(2-(2′,3-dichlorobiphen...)
Affinity DataEC50:  137nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230062(Sodium 6-chloro-7-(4-(2-chloro-4-cyclopropylphenet...)
Affinity DataEC50:  301nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230063(Sodium 6-chloro-7-(4-(2-(3-chlorobiphenyl-4-yl)eth...)
Affinity DataEC50:  91.4nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230064(Sodium 7-(4-(2-bromo-4-chlorophenethylcarbamoyl)ph...)
Affinity DataEC50:  88nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin D2 receptor 2(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM230065(Sodium 6-chloro-7-(4-(2-(2′,5-dichlorobiphen...)
Affinity DataEC50:  126nMpH: 7.4 T: 2°CAssay Description:The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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