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Report error Found 217 Enz. Inhib. hit(s) with Target = 'Polyunsaturated fatty acid lipoxygenase ALOX15B'
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572160(CHEMBL1452107)
Affinity DataEC50:  600nMAssay Description:Inhibition of human 15-LOX-2 expressed in HEK293T cells assessed as a reduction in 15-HETE production using arachidonic acid as substrate incubated f...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM68853(cid_3696046 | SMR000179722 | 1-phenyl-2-{[4-(trifl...)
Affinity DataEC50:  750nMAssay Description:Inhibition of human 15-LOX-2 expressed in HEK293T cells assessed as a reduction in 15-HETE production using arachidonic acid as substrate incubated f...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572161(CHEMBL1520238 | US20240317691, Compound 106)
Affinity DataEC50:  3.10E+4nMAssay Description:Inhibition of human 15-LOX-2 expressed in HEK293T cells assessed as a reduction in 15-HETE production using arachidonic acid as substrate incubated f...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572162(CHEMBL1352020 | US20240317691, Compound 107)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of human 15-LOX-2 expressed in HEK293T cells assessed as a reduction in 15-HETE production using arachidonic acid as substrate incubated f...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50516347(CHEMBL4531593)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of thymidylate synthase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50570887(CHEMBL4857252)
Affinity DataIC50: 57nMAssay Description:Inhibition of thymidylate synthase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50235696(CHEMBL4060383)
Affinity DataIC50: 120nMAssay Description:Inhibition of human thymidylate synthase using dUMP/(6R,S)-tetrahydrofolate as substrate/co-factor by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50512138(CHEMBL4550585)
Affinity DataIC50: 130nMAssay Description:Inhibition of human thymidylate synthase using dUMP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50528941(CHEMBL4470361)
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant human His6-tagged TS using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50235700(CHEMBL4096329)
Affinity DataIC50: 140nMAssay Description:Inhibition of human thymidylate synthase using dUMP/(6R,S)-tetrahydrofolate as substrate/co-factor by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50009001(CHEMBL8260 | Baicalein | 5,6,7-Trihydroxyflavone |...)
Affinity DataIC50: 260nMAssay Description:Inhibitory activity against 15-lipoxygenase in rat polymorphonuclear leukocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50528943(CHEMBL4562561)
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human His6-tagged TS using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50528948(CHEMBL4451239)
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human His6-tagged TS using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM697971(US20240317691, Compound 101)
Affinity DataIC50: 270nMAssay Description:The full IC50 experiments were done with at least five different inhibitor concentrations. All reaction mixtures were 2 mL in volume and constantly s...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50011932(CHEMBL38168 | 2-Cyano-3-(3,4-dihydroxy-phenyl)-acr...)
Affinity DataIC50: 330nMAssay Description:Inhibitory activity against 15-lipoxygenase in rat polymorphonuclear leukocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM68853(cid_3696046 | SMR000179722 | 1-phenyl-2-{[4-(trifl...)
Affinity DataIC50: 340nMAssay Description:Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM68853(cid_3696046 | SMR000179722 | 1-phenyl-2-{[4-(trifl...)
Affinity DataIC50: 340nMAssay Description:The full IC50 experiments were done with at least five different inhibitor concentrations. All reaction mixtures were 2 mL in volume and constantly s...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM68853(cid_3696046 | SMR000179722 | 1-phenyl-2-{[4-(trifl...)
Affinity DataIC50: 340nMAssay Description:The full IC50 experiments were done with at least five different inhibitor concentrations. All reaction mixtures were 2 mL in volume and constantly s...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50027655(CHEBI:5847 | Raltitrexed | Tomudex | ZD-16 | ZD-16...)
Affinity DataIC50: 380nMAssay Description:Inhibition of human thymidylate synthase using dUMP/(6R,S)-tetrahydrofolate as substrate/co-factor by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50528946(CHEMBL4459197)
Affinity DataIC50: 390nMAssay Description:Inhibition of recombinant human His6-tagged TS using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50011934(CHEMBL37154 | 2-Cyano-3-(3,4-dihydroxy-phenyl)-acr...)
Affinity DataIC50: 430nMAssay Description:Inhibitory activity against 15-lipoxygenase in rat polymorphonuclear leukocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50512145(CHEMBL4546953)
Affinity DataIC50: 450nMAssay Description:Inhibition of human thymidylate synthase using dUMP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50528945(CHEMBL4565065)
Affinity DataIC50: 460nMAssay Description:Inhibition of recombinant human His6-tagged TS using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50528940(CHEMBL4544605)
Affinity DataIC50: 470nMAssay Description:Inhibition of recombinant human His6-tagged TS using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50235699(CHEMBL4079829)
Affinity DataIC50: 480nMAssay Description:Inhibition of human thymidylate synthase using dUMP/(6R,S)-tetrahydrofolate as substrate/co-factor by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50011938(CHEMBL37081 | 2-Cyano-3-(3,4-dihydroxy-phenyl)-acr...)
Affinity DataIC50: 500nMAssay Description:Inhibitory activity against 15-lipoxygenase in rat polymorphonuclear leukocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572161(CHEMBL1520238 | US20240317691, Compound 106)
Affinity DataIC50: 530nMAssay Description:Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572161(CHEMBL1520238 | US20240317691, Compound 106)
Affinity DataIC50: 530nMAssay Description:The full IC50 experiments were done with at least five different inhibitor concentrations. All reaction mixtures were 2 mL in volume and constantly s...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572161(CHEMBL1520238 | US20240317691, Compound 106)
Affinity DataIC50: 530nMAssay Description:The full IC50 experiments were done with at least five different inhibitor concentrations. All reaction mixtures were 2 mL in volume and constantly s...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50512143(CHEMBL4587877)
Affinity DataIC50: 560nMAssay Description:Inhibition of human thymidylate synthase using dUMP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50512137(CHEMBL4457367)
Affinity DataIC50: 600nMAssay Description:Inhibition of human thymidylate synthase using dUMP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50528958(CHEMBL4476613)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human His6-tagged TS using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50528951(CHEMBL4458803)
Affinity DataIC50: 700nMAssay Description:Inhibition of recombinant human His6-tagged TS using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50512136(CHEMBL4460523)
Affinity DataIC50: 740nMAssay Description:Inhibition of human thymidylate synthase using dUMP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50528947(CHEMBL4445927)
Affinity DataIC50: 800nMAssay Description:Inhibition of recombinant human His6-tagged TS using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50512142(CHEMBL4543727)
Affinity DataIC50: 870nMAssay Description:Inhibition of human thymidylate synthase using dUMP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572162(CHEMBL1352020 | US20240317691, Compound 107)
Affinity DataIC50: 870nMAssay Description:Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572162(CHEMBL1352020 | US20240317691, Compound 107)
Affinity DataIC50: 870nMAssay Description:The full IC50 experiments were done with at least five different inhibitor concentrations. All reaction mixtures were 2 mL in volume and constantly s...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572162(CHEMBL1352020 | US20240317691, Compound 107)
Affinity DataIC50: 870nMAssay Description:The full IC50 experiments were done with at least five different inhibitor concentrations. All reaction mixtures were 2 mL in volume and constantly s...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50528950(CHEMBL4454174)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human His6-tagged TS using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50235698(CHEMBL4069070)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human thymidylate synthase using dUMP/(6R,S)-tetrahydrofolate as substrate/co-factor by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50528955(CHEMBL4445309)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant human His6-tagged TS using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50512139(CHEMBL4458595)
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of human thymidylate synthase using dUMP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50528949(CHEMBL4536417)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human His6-tagged TS using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50528957(CHEMBL4570994)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human His6-tagged TS using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50011930(CHEMBL35934 | 2-Cyano-3-(3,4-dihydroxy-phenyl)-acr...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory activity against 15-lipoxygenase in rat polymorphonuclear leukocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50512146(CHEMBL4459098)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of human thymidylate synthase using dUMP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50011935(CHEMBL37180 | 2-Cyano-3-(3,4-dihydroxy-phenyl)-acr...)
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibitory activity against 15-lipoxygenase in rat polymorphonuclear leukocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50512140(CHEMBL4591608)
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of human thymidylate synthase using dUMP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50528939(CHEMBL4447254)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of recombinant human His6-tagged TS using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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