Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with Target = 'Peroxisome proliferator-activated receptor gamma/Retinoic acid receptor RXR-alpha'
LigandPNGBDBM50132585((2E,4Z,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-et...)
Affinity DataEC50:  143nMAssay Description:Synergistic activation of BRL-49653 mediated PPAR gamma and retinoid X receptor alpha expressed in CV-1 cell transcriptional activation assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50111006(5-{3-[4-(2-Furan-2-yl-5-methyl-oxazol-4-ylmethoxy)...)
Affinity DataEC50:  8.87nMAssay Description:Transcriptional activation in COS cells expressing PPAR gamma and RXR alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50111007(5-{3-[6-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-pyr...)
Affinity DataEC50:  16.5nMAssay Description:Transcriptional activation in COS cells expressing PPAR gamma and RXR alphaMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50111008(5-{3-[4-(5-Methyl-2-phenyl-thiazol-4-ylmethoxy)-ph...)
Affinity DataEC50:  269nMAssay Description:Transcriptional activation in COS cells expressing PPAR gamma and RXR alphaMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50111009(5-{3-[4-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-phe...)
Affinity DataEC50:  119nMAssay Description:Transcriptional activation in COS cells expressing PPAR gamma and RXR alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50111010(5-{3-[4-(5-Methyl-2-naphthalen-2-yl-oxazol-4-ylmet...)
Affinity DataEC50:  29.3nMAssay Description:Transcriptional activation in COS cells expressing PPAR gamma and RXR alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50132584((2Z,4E,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-et...)
Affinity DataEC50:  2.70nMAssay Description:Synergistic activation of BRL-49653 mediated PPAR gamma and retinoid X receptor alpha expressed in CV-1 cell transcriptional activation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129728(7-(3,5-Di-tert-butyl-2-ethoxy-phenyl)-3-methyl-oct...)
Affinity DataEC50:  2nMAssay Description:Synergistic activation of BRL-49653 mediated PPAR gamma and retinoid X receptor alpha expressed in CV-1 cell transcriptional activation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50132583((2E,4E,6E)-7-(3,5-Di-tert-butyl-2-ethoxy-phenyl)-8...)
Affinity DataEC50:  167nMAssay Description:Synergistic activation of BRL-49653 mediated PPAR gamma and retinoid X receptor alpha expressed in CV-1 cell transcriptional activation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50049240((+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)m...)
Affinity DataEC50:  490nMAssay Description:Transcriptional activation in COS cells expressing PPAR gamma and RXR alpha; values in the parentheses indicates 95% confidence intervalMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50132581((2E,4Z,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-et...)
Affinity DataEC50:  249nMAssay Description:Synergistic activation of BRL-49653 mediated PPAR gamma and retinoid X receptor alpha expressed in CV-1 cell transcriptional activation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50132582((2Z,4E,6Z)-7-(2-Butoxy-3,5-di-tert-butyl-phenyl)-3...)
Affinity DataEC50:  359nMAssay Description:Synergistic activation of BRL-49653 mediated PPAR gamma and retinoid X receptor alpha expressed in CV-1 cell transcriptional activation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50132580((2E,4E,6E)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-et...)
Affinity DataEC50:  6.40nMAssay Description:Synergistic activation of BRL-49653 mediated PPAR gamma and retinoid X receptor alpha expressed in CV-1 cell transcriptional activation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129720(7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-pheny...)
Affinity DataEC50:  3.10nMAssay Description:Synergistic activation of BRL-49653 mediated PPAR gamma and retinoid X receptor alpha expressed in CV-1 cell transcriptional activation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50132579((2E,4E,6Z)-7-(2-Butoxy-3,5-di-tert-butyl-phenyl)-3...)
Affinity DataEC50:  9.20nMAssay Description:Synergistic activation of BRL-49653 mediated PPAR gamma and retinoid X receptor alpha expressed in CV-1 cell transcriptional activation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human CMV-fused PPARgamma LBD/RXRalpha (unknown origin) expressed in African green monkey CV1 cells transfected with luciferase p...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50563863(CHEMBL4787498)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human CMV-fused PPARgamma LBD/RXRalpha (unknown origin) expressed in African green monkey CV1 cells transfected with luciferase p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50204012(CHEMBL3955132)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human CMV-fused PPARgamma LBD/RXRalpha (unknown origin) expressed in African green monkey CV1 cells transfected with luciferase p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129726((2E,4E,6Z)-7-(2-Ethoxy-3,5-diisopropyl-phenyl)-3-m...)
Affinity DataEC50:  1nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129724(7-(3,5-Diisopropyl-2-propoxy-phenyl)-3-methyl-octa...)
Affinity DataEC50:  5nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129720(7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-pheny...)
Affinity DataEC50:  3nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129725(7-(2-Butoxy-3,5-diisopropyl-phenyl)-3-methyl-octa-...)
Affinity DataEC50:  12nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129723(7-[2-(2-Fluoro-ethoxy)-3,5-diisopropyl-phenyl]-3-m...)
Affinity DataEC50:  4nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129721(7-[2-(2,2-Difluoro-ethoxy)-3,5-bis-(1,1-dimethyl-p...)
Affinity DataEC50:  11nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129731(7-[2-(2,2-Difluoro-ethoxy)-3,5-diisopropyl-phenyl]...)
Affinity DataEC50:  10nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129729(7-[3,5-Bis-(1,1-dimethyl-propyl)-2-propoxy-phenyl]...)
Affinity DataEC50:  19nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129717(7-(3,5-Diisopropyl-2-methoxy-phenyl)-3-methyl-octa...)
Affinity DataEC50:  8nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50111008(5-{3-[4-(5-Methyl-2-phenyl-thiazol-4-ylmethoxy)-ph...)
Affinity DataEC50:  813nMAssay Description:Transcriptional activation in COS cells expressing PPAR gamma and RXR alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129733(7-[3,5-Diisopropyl-2-(2,2,2-trifluoro-ethoxy)-phen...)
Affinity DataEC50:  3nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-nap...)
Affinity DataEC50:  38nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50129722(7-[3,5-Bis-(1,1-dimethyl-propyl)-2-ethoxy-phenyl]-...)
Affinity DataEC50:  9nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129728(7-(3,5-Di-tert-butyl-2-ethoxy-phenyl)-3-methyl-oct...)
Affinity DataEC50:  2nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129727(7-[3,5-Di-tert-butyl-2-(2,2,2-trifluoro-ethoxy)-ph...)
Affinity DataEC50:  2nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129730(7-[3,5-Bis-(1,1-dimethyl-propyl)-2-methoxy-phenyl]...)
Affinity DataEC50:  6nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129718(7-(3,5-Di-tert-butyl-2-propoxy-phenyl)-3-methyl-oc...)
Affinity DataEC50:  154nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50129719(7-(3,5-Di-tert-butyl-2-methoxy-phenyl)-3-methyl-oc...)
Affinity DataEC50:  7nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed