Report error Found 5585 Enz. Inhib. hit(s) with Target = 'Peroxisome proliferator-activated receptor alpha'
Displayed 1 to 50 (of 5585 total ) | Next | Last >>
Affinity DataEC50: 0.0000500nMAssay Description:Transactivation of human PPARalpha expressed in human HepG2 cells co-transfected with PPRE3-TK-Luc by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0000600nMAssay Description:Transactivation of human PPARalpha expressed in human HepG2 cells co-transfected with PPRE3-TK-Luc by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0000700nMAssay Description:Transactivation of human PPARalpha expressed in human HepG2 cells co-transfected with PPRE3-TK-Luc by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.000310nMAssay Description:Transactivation of human PPARalpha expressed in human HepG2 cells co-transfected with PPRE3-TK-Luc by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.00380nMAssay Description:Agonist activity at human PPARalpha transactivation expressed in human HePG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0260nMAssay Description:Transactivation of human PPARalpha expressed in human HepG2 cells co-transfected with PPRE3-TK-Luc by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0300nMAssay Description:Agonist activity at PPARalpha expressed in human HepG2 cells assessed as induction of receptor transactivation by reporter gene assay relative to con...More data for this Ligand-Target Pair
Affinity DataKi: 0.0541nMAssay Description:Displacement of Fluormone-Pan-PPAR Green from human GST-tagged PPARalpha LBD by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0720nMAssay Description:Agonist activity at PPARalpha expressed in human HepG2 cells assessed as induction of receptor transactivation by reporter gene assay relative to con...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0890nMAssay Description:Agonist activity at PPARalpha expressed in human HepG2 cells assessed as induction of receptor transactivation by reporter gene assay relative to con...More data for this Ligand-Target Pair
Affinity DataEC50: 0.100nMAssay Description:Transactivation of human PPARalpha expressed in human HepG2 cells co-transfected with PPRE3-TK-Luc by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.150nMAssay Description:Effective concentration against murine PPARalpha in transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.160nMAssay Description:Agonist activity at GAL4-tagged PPARalpha ligand-binding domain (unknown origin) expressed in HEK293T cells incubated for 16 to 19 hrs by beta-lactam...More data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Effective concentration against murine PPARalpha in transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.270nMAssay Description:Effective concentration against murine PPARalpha in transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.272nMAssay Description:Agonist activity at PPARalpha expressed in human HepG2 cells assessed as induction of receptor transactivation by reporter gene assay relative to con...More data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at human PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.350nMAssay Description:Effective concentration against murine PPARalpha in transactivation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.460nMAssay Description:Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Dog)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataEC50: 0.550nMAssay Description:Agonist activity at dog PPARalpha receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.590nMAssay Description:Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Agonist activity at PPARalpha expressed in human HepG2 cells assessed as induction of receptor transactivation by reporter gene assay relative to con...More data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Agonist activity at human PPARalpha transfected in african green monkey COS7 cells assessed transactivation incubated for 16 hrs by luciferase assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataEC50: 0.600nMAssay Description:Activation of PPARalpha transfected in HEK293 cells after 18 hrs by firefly luciferase reporter gene-based luminescence assay relative to controlMore data for this Ligand-Target Pair
Affinity DataEC50: 0.615nMAssay Description:Transcriptional activation activity on human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.650nMAssay Description:Agonist activity at PPARalpha in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.700nMAssay Description:Agonist activity at human PPARalpha transfected in african green monkey COS7 cells assessed transactivation incubated for 16 hrs by luciferase assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.75nMAssay Description:Binding affinity to PPARalpha (unknown origin) assessed as thermodynamic dissociation constant by SPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.800nMAssay Description:Agonist activity at human PPARalpha transfected in african green monkey COS7 cells assessed transactivation incubated for 16 hrs by luciferase assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataEC50: 0.850nMAssay Description:Agonist activity at Gal4-fused human PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated f...More data for this Ligand-Target Pair
Affinity DataKd: 0.860nMAssay Description:Binding affinity to PPARalpha (unknown origin) assessed as thermodynamic dissociation constant by SPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.870nMAssay Description:Agonist activity at Gal4-fused human PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated f...More data for this Ligand-Target Pair
Affinity DataEC50: 0.890nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.900nMAssay Description:Agonist activity at human PPARalpha transfected in african green monkey COS7 cells assessed transactivation incubated for 16 hrs by luciferase assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataEC50: 0.950nMAssay Description:Agonist activity at Gal4-fused human PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated f...More data for this Ligand-Target Pair
Affinity DataKd: 1nMAssay Description:Binding affinity to human PPARalpha (unknown origin) by competitive TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Transactivation of Homo sapiens (human) PPARalpha assessed as luciferase activity by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR alpha ligand binding domainMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at GAL4-tagged PPARalpha ligand-binding domain (unknown origin) expressed in HEK293T cells incubated for 16 to 19 hrs by beta-lactam...More data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at Gal4-fused PPARalpha LBD (unknown origin) transfected in human HepG2 cells assessed as transcriptional activation incubated for 2...More data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Transcriptional activation of reporter assay by human Peroxisome proliferator activated receptor alpha in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at human PPARalpha transactivation expressed in human HePG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Transactivation by human PPAR alpha in COS1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at human recombinant PPARalpha by GAL4 transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at human PPARalpha transfected in african green monkey COS7 cells assessed transactivation incubated for 16 hrs by luciferase assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataEC50: 1nMAssay Description:Activation of murine PPAR alpha ligand binding domainMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at human recombinant PPARalpha by GAL4 transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at human recombinant PPARalpha by GAL4 transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at human recombinant PPARalpha by GAL4 transactivation assayMore data for this Ligand-Target Pair








3D Structure (crystal)

































