Compile Data Set for Download or QSAR
Report error Found 8243 Enz. Inhib. hit(s) with Target = 'P2X purinoceptor 3'
TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50219120(LVVYPWT | CHEMBL395493)
Affinity DataIC50: 0.00830nMAssay Description:Antagonist activity at human P2X3 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current by two electrode voltage cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50219120(LVVYPWT | CHEMBL395493)
Affinity DataIC50: 0.0481nMAssay Description:Antagonist activity at human recombinant P2X3 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM648786(US20240034729, Compound 178)
Affinity DataIC50: 0.100nMAssay Description:The antagonist property of the compounds disclosed herein was determined using the FLIPR (fluorescence imaging plate reader) method, showing that the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM648788(US20240034729, Compound 180)
Affinity DataIC50: 0.200nMAssay Description:The antagonist property of the compounds disclosed herein was determined using the FLIPR (fluorescence imaging plate reader) method, showing that the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM648787(US20240034729, Compound 179)
Affinity DataIC50: 0.400nMAssay Description:The antagonist property of the compounds disclosed herein was determined using the FLIPR (fluorescence imaging plate reader) method, showing that the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM648780(US20240034729, Compound 172)
Affinity DataIC50: 0.700nMAssay Description:The antagonist property of the compounds disclosed herein was determined using the FLIPR (fluorescence imaging plate reader) method, showing that the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM196325(US9212130, I-245)
Affinity DataIC50: 0.800nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266044(US9718790, I-2105)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266712(US9718790, I-2446)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM244280(US9550763, Compound I-028)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM319931(US10174016, Example 98 | 3-(5-Methyl- 1,3-thiazol-...)
Affinity DataIC50: 1nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266170(US9718790, I-2157)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM319931(US10174016, Example 98 | 3-(5-Methyl- 1,3-thiazol-...)
Affinity DataIC50: 1nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM244385(US9550763, Compound I-137)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM244285(US9550763, Compound I-033)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM244381(US9550763, Compound I-133)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266301(US9718790, I-2203)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM196345(US9212130, I-265)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266411(US9718790, I-2241)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266855(US9718790, I-2593)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266536(US9718790, I-2288)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266759(US9718790, I-2494)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266248(US9718790, I-2183)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266215(US9718790, I-2172)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM319931(US10174016, Example 98 | 3-(5-Methyl- 1,3-thiazol-...)
Affinity DataIC50: 1nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266086(US9718790, I-2119)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM319931(US10174016, Example 98 | 3-(5-Methyl- 1,3-thiazol-...)
Affinity DataIC50: 1nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266068(US9718790, I-2113)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266736(US9718790, I-2470)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266955(US9718790, I-2701)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266762(US9718790, I-2497)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM648785(US20240034729, Compound 177)
Affinity DataIC50: 1.10nMAssay Description:The antagonist property of the compounds disclosed herein was determined using the FLIPR (fluorescence imaging plate reader) method, showing that the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM648782(US20240034729, Compound 174)
Affinity DataIC50: 1.60nMAssay Description:The antagonist property of the compounds disclosed herein was determined using the FLIPR (fluorescence imaging plate reader) method, showing that the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM648781(US20240034729, Compound 173)
Affinity DataIC50: 1.80nMAssay Description:The antagonist property of the compounds disclosed herein was determined using the FLIPR (fluorescence imaging plate reader) method, showing that the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM648789(US20240034729, Compound 181)
Affinity DataIC50: 1.80nMAssay Description:The antagonist property of the compounds disclosed herein was determined using the FLIPR (fluorescence imaging plate reader) method, showing that the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266047(US9718790, I-2106)
Affinity DataIC50: 2nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266570(US9718790, I-2302)
Affinity DataIC50: 2nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM244265(US9550763, Compound I-013)
Affinity DataIC50: 2nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM244264(US9550763, Compound I-012)
Affinity DataIC50: 2nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM244263(US9550763, Compound I-011)
Affinity DataIC50: 2nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM320075(US10174016, Example 242 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 2nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266577(US9718790, I-2309)
Affinity DataIC50: 2nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266574(US9718790, I-2306)
Affinity DataIC50: 2nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266331(US9718790, I-2213)
Affinity DataIC50: 2nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM106341(US8575197, II-254)
Affinity DataIC50: 2nMAssay Description:Inhibition assay using human P2X3 receptor gene (GeneBank accession number Y07683).More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM266328(US9718790, I-2212)
Affinity DataIC50: 2nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM196324(US9212130, I-244)
Affinity DataIC50: 2nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM320216(3-{[4,4- difluoro-1- methylpiperidin- 3-yl]methoxy...)
Affinity DataIC50: 2nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM244290(US9550763, Compound I-038)
Affinity DataIC50: 2nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
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TargetP2X purinoceptor 3(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM320041(US10174016, Example 208)
Affinity DataIC50: 2nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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