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Report error Found 8200 Enz. Inhib. hit(s) with Target = 'P2X purinoceptor 3'
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118226(PAPET-ATP | CHEMBL337062)
Affinity DataEC50:  17nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM,expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118221(alpha,beta-meATP | DIPHOSPHOMETHYLPHOSPHONIC ACID ...)
Affinity DataEC50:  740nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118220(adenosine(5')tetraphospho(5')adenosine | P(1),P(4)...)
Affinity DataEC50:  500nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50336799(Suramin hexasodium | Germanin | suramin | 8,8'-[Ca...)
Affinity DataEC50:  1.49E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118217(PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | ATPga...)
Affinity DataEC50:  690nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118240(((2R,3S,4R,5R)-5-(6-amino-2-(hexylthio)-9H-purin-9...)
Affinity DataEC50:  350nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM,expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50336799(Suramin hexasodium | Germanin | suramin | 8,8'-[Ca...)
Affinity DataEC50:  3.00E+3nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X2) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118222(MRS 2257)
Affinity DataEC50:  22nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 3 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50370141(TNP-ATP)
Affinity DataEC50:  1.52E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118232(ATP, 2-meS | CHEMBL336208 | 2-MeSATP)
Affinity DataEC50:  350nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM85043(CHEMBL69234 | CAS_149017-66-3 | NSC_6093163 | PPAD...)
Affinity DataEC50:  1.70E+3nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50370141(TNP-ATP)
Affinity DataEC50:  1.52E+4nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 3 (P2X3 )More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM85043(CHEMBL69234 | CAS_149017-66-3 | NSC_6093163 | PPAD...)
Affinity DataEC50:  240nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM,expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50366480(ATP | ADENOSINE TRIPHOSPHATE)
Affinity DataEC50:  340nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50594506(CHEMBL5183218)
Affinity DataEC50: <1.00E+5nMAssay Description:Agonist activity at human P2X3R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by c...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118219(Bz-ATP | CHEMBL339386)
Affinity DataEC50:  80nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50594505(CHEMBL5177316)
Affinity DataEC50: <1.00E+5nMAssay Description:Agonist activity at human P2X3R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by c...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50370142(CHEMBL133463)
Affinity DataEC50:  9.20E+3nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 3 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118230(5'-O-[(R)-HYDROXY(THIOPHOSPHONOOXY)PHOSPHORYL]ADEN...)
Affinity DataEC50:  8.80E+3nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataEC50: >1.00E+5nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataEC50:  1.30E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 30 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50219120(LVVYPWT | CHEMBL395493)
Affinity DataIC50: 0.00830nMAssay Description:Antagonist activity at human P2X3 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current by two electrode voltage cl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50219120(LVVYPWT | CHEMBL395493)
Affinity DataIC50: 0.0481nMAssay Description:Antagonist activity at human recombinant P2X3 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current in presence of ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM648786(US20240034729, Compound 178)
Affinity DataIC50: 0.100nMAssay Description:The antagonist property of the compounds disclosed herein was determined using the FLIPR (fluorescence imaging plate reader) method, showing that the...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM648788(US20240034729, Compound 180)
Affinity DataIC50: 0.200nMAssay Description:The antagonist property of the compounds disclosed herein was determined using the FLIPR (fluorescence imaging plate reader) method, showing that the...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM648787(US20240034729, Compound 179)
Affinity DataIC50: 0.400nMAssay Description:The antagonist property of the compounds disclosed herein was determined using the FLIPR (fluorescence imaging plate reader) method, showing that the...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM648780(US20240034729, Compound 172)
Affinity DataIC50: 0.700nMAssay Description:The antagonist property of the compounds disclosed herein was determined using the FLIPR (fluorescence imaging plate reader) method, showing that the...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM196325(US9212130, I-245)
Affinity DataIC50: 0.800nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM266712(US9718790, I-2446)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM266736(US9718790, I-2470)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM266759(US9718790, I-2494)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM266762(US9718790, I-2497)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM266855(US9718790, I-2593)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM266955(US9718790, I-2701)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM266044(US9718790, I-2105)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM266068(US9718790, I-2113)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM266086(US9718790, I-2119)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM266170(US9718790, I-2157)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM266215(US9718790, I-2172)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM266248(US9718790, I-2183)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM266301(US9718790, I-2203)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM244280(US9550763, Compound I-028)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM244285(US9550763, Compound I-033)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM266411(US9718790, I-2241)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM244381(US9550763, Compound I-133)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM244385(US9550763, Compound I-137)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM266536(US9718790, I-2288)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM319931(US10174016, Example 98 | 3-(5-Methyl- 1,3-thiazol-...)
Affinity DataIC50: 1nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM319931(US10174016, Example 98 | 3-(5-Methyl- 1,3-thiazol-...)
Affinity DataIC50: 1nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM319931(US10174016, Example 98 | 3-(5-Methyl- 1,3-thiazol-...)
Affinity DataIC50: 1nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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