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Report error Found 54 Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2 [888-1187]'
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)
Affinity DataIC50: 2nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)
Affinity DataIC50: 2nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 6nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 6nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataIC50: 30nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 30nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataIC50: 30nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 30nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM294916(US10112907, Example 00027 | US10206907, Compound 1...)
Affinity DataIC50: 110nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM294912(US10112907, Example 00021)
Affinity DataIC50: 110nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM294916(US10112907, Example 00027 | US10206907, Compound 1...)
Affinity DataIC50: 110nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM147644(US8962608, 25-24 | US8962608, 25-5 | US10766894, C...)
Affinity DataIC50: 110nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM294915(US10112907, Example 00026)
Affinity DataIC50: 120nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM462294(US10766894, Compound TABLE 1.11 | US11203595, TABL...)
Affinity DataIC50: 120nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410174(US10370375, Example 22)
Affinity DataIC50: 130nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50402074(CHEMBL2206059 | US10112907, Example 00024 | US1076...)
Affinity DataIC50: 140nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50402074(CHEMBL2206059 | US10112907, Example 00024 | US1076...)
Affinity DataIC50: 140nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 230nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 230nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 310nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 310nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410170(US10370375, Example 18)
Affinity DataIC50: 390nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 780nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 780nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410178(US10370375, Example 26)
Affinity DataIC50: 840nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410177(US10370375, Example 25)
Affinity DataIC50: 1.10E+3nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50021655(VRT-831509 | VX-509 | DECERNOTINIB | US10112907, E...)
Affinity DataIC50: 1.50E+3nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50021655(VRT-831509 | VX-509 | DECERNOTINIB | US10112907, E...)
Affinity DataIC50: 1.50E+3nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM147692(US8962608, 28-1 | US10112907, Example 00025)
Affinity DataIC50: 1.80E+3nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM462293(US10766894, Compound TABLE 1.10 | US11203595, TABL...)
Affinity DataIC50: 1.80E+3nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410180(US10370375, Example 28)
Affinity DataIC50: 3.20E+3nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410154(US10370375, Example 2)
Affinity DataIC50: 4.59E+3nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410153(US10370375, Example 1)
Affinity DataIC50: 5.51E+3nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410165(US10370375, Example 13)
Affinity DataIC50: 6.00E+3nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410179(US10370375, Example 27)
Affinity DataIC50: 7.80E+3nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410176(US10370375, Example 24)
Affinity DataIC50: 8.50E+3nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410163(US10370375, Example 11)
Affinity DataIC50: 1.00E+4nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410155(US10370375, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410156(US10370375, Example 4)
Affinity DataIC50: 1.00E+4nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410157(US10370375, Example 5)
Affinity DataIC50: 1.00E+4nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410158(US10370375, Example 6)
Affinity DataIC50: 1.00E+4nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410159(US10370375, Example 7)
Affinity DataIC50: 1.00E+4nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410160(US10370375, Example 8)
Affinity DataIC50: 1.00E+4nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410161(US10370375, Example 9)
Affinity DataIC50: 1.00E+4nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410162(US10370375, Example 10)
Affinity DataIC50: 1.00E+4nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410168(US10370375, Example 16)
Affinity DataIC50: 1.00E+4nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410164(US10370375, Example 12)
Affinity DataIC50: 1.00E+4nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410175(US10370375, Example 23)
Affinity DataIC50: 1.00E+4nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410166(US10370375, Example 14)
Affinity DataIC50: 1.00E+4nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM410173(US10370375, Example 21)
Affinity DataIC50: 1.00E+4nMAssay Description:All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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