Compile Data Set for Download or QSAR
Report error Found 74 Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK2'
LigandPNGBDBM50530400(CHEMBL4548200)
Affinity DataIC50: 27nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50530400(CHEMBL4548200)
Affinity DataIC50: 27nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 46nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530383(CHEMBL4530719)
Affinity DataIC50: 46nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50572395(CHEMBL4864387)
Affinity DataIC50: 50nMAssay Description:Inhibition of JAK2/TYK2 signaling pathway in human whole blood assessed as reduction in IL-12 induced STAT4 phosphorylation incubated for 60 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530398(CHEMBL4526283)
Affinity DataIC50: 63nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50530398(CHEMBL4526283)
Affinity DataIC50: 63nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50530396(CHEMBL4544320)
Affinity DataIC50: 71nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530385(CHEMBL4472802)
Affinity DataIC50: 71nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530385(CHEMBL4472802)
Affinity DataIC50: 71nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530396(CHEMBL4544320)
Affinity DataIC50: 71nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530401(CHEMBL4444606)
Affinity DataIC50: 75nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530401(CHEMBL4444606)
Affinity DataIC50: 75nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataIC50: 82nMAssay Description:Inhibition of JAK2/TYK2 in human whole blood assessed as inhibition of IL-23-induced STAT-3 phosphorylation preincubated for 45 mins followed by IL-2...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50: 84nMAssay Description:Inhibition of JAK2/Tyk2 in human PBMC assessed as reduction in IL-23-induced Stat3 phosphorylation in CD3+CD4+ cells preincubated for 30 mins followe...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 89nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 89nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530391(CHEMBL4444169)
Affinity DataIC50: 110nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530391(CHEMBL4444169)
Affinity DataIC50: 110nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM305821(US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...)
Affinity DataIC50: 112nMAssay Description:Inhibition of JAK2/TYK2 signaling pathway in human whole blood lymphocytes assessed as reduction in IL-23 induced STAT3 phosphorylation preincubated ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM329924(US9663526, Example 7 | US10463675, Example 7 | US1...)
Affinity DataIC50: 120nMAssay Description:Inhibition of JAK2/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-23 induced STAT3 phosphorylation preincubat...More data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM329924(US9663526, Example 7 | US10463675, Example 7 | US1...)
Affinity DataIC50: 120nMAssay Description:Inhibition of JAK2/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-23 induced STAT3 phosphorylation preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataIC50: 149nMAssay Description:Inhibition of JAK2/TYK2 in human whole blood assessed as inhibition of IL-12-induced STAT-4 phosphorylation preincubated for 45 mins followed by IL-1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataIC50: 200nMAssay Description:Inhibition of TYK2/JAK2 in human PBMC assessed as reduction in IL-23-induced STAT4 phosphorylation preincubated for 5 mins followed by IL-23 stimulat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 229nMAssay Description:Inhibition of JAK2/TYK2 in human whole blood assessed as inhibition of IL-23-induced STAT-3 phosphorylation preincubated for 45 mins followed by IL-2...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50146024(CHEMBL3765822)
Affinity DataIC50: 230nMAssay Description:Inhibition of TYK2/JAK2 in human PBMC assessed as reduction in IL-23-induced STAT4 phosphorylation preincubated for 5 mins followed by IL-23 stimulat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 249nMAssay Description:Inhibition of JAK2/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-23 induced STAT3 phosphorylation preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 249nMAssay Description:Inhibition of JAK2/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-23 induced STAT3 phosphorylation preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530393(CHEMBL4465409)
Affinity DataIC50: 280nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530393(CHEMBL4465409)
Affinity DataIC50: 280nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: 299nMAssay Description:Inhibition of JAK2/TYK2 signalling in human PBMC assessed as inhibition of IL-23 stimulated phosphorylation of STAT3 preincubated for 60 mins followe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530402(CHEMBL4460194)
Affinity DataIC50: 310nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530402(CHEMBL4460194)
Affinity DataIC50: 310nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530392(CHEMBL4469812)
Affinity DataIC50: 330nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530392(CHEMBL4469812)
Affinity DataIC50: 330nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530399(CHEMBL4476830)
Affinity DataIC50: 380nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530399(CHEMBL4476830)
Affinity DataIC50: 380nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 409nMAssay Description:Inhibition of JAK2/TYK2 in human whole blood assessed as inhibition of IL-12-induced STAT-4 phosphorylation preincubated for 45 mins followed by IL-1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530389(CHEMBL4438202)
Affinity DataIC50: 430nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50530389(CHEMBL4438202)
Affinity DataIC50: 430nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50530388(CHEMBL4453545)
Affinity DataIC50: 490nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530388(CHEMBL4453545)
Affinity DataIC50: 490nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50572395(CHEMBL4864387)
Affinity DataIC50: 652nMAssay Description:Inhibition of JAK2/TYK2 signaling pathway in human whole blood assessed as reduction in IL-23 induced STAT3 phosphorylation incubated for 60 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530386(CHEMBL4537678)
Affinity DataIC50: 660nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50530386(CHEMBL4537678)
Affinity DataIC50: 660nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 818nMAssay Description:Inhibition of JAK2/TYK2 in human whole blood assessed as inhibition of IL-23-induced STAT-3 phosphorylation preincubated for 45 mins followed by IL-2...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of JAK2/TYK2 in human whole blood assessed as inhibition of IL-12-induced STAT-4 phosphorylation preincubated for 45 mins followed by IL-1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50530387(CHEMBL4531793)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50530387(CHEMBL4531793)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50593320(IFIDANCITINIB | Ifidancitinib | Ati-502 | A-301 | ...)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of JAK2/TYK2 signaling pathway in human primary T-cells assessed as reduction of IL-12 induced STAT4 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails
PubMed
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