Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with Target = 'Nitric oxide synthase, brain [D597N]'
TargetNitric oxide synthase, brain [D597N](Rat)
University of California Irvine

LigandPNGBDBM190667(nNOS inhibitor, 5 | US10759791, Compound 14j)
Affinity DataKi:  46.7nM ΔG°:  -43.5kJ/molepH: 7.4 T: 2°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain [D597N](Rat)
University of California Irvine

LigandPNGBDBM190668(nNOS inhibitor, 6 | US10759791, Compound 14k)
Affinity DataKi:  97.5nM ΔG°:  -41.6kJ/molepH: 7.4 T: 2°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain [D597N](Rat)
University of California Irvine

LigandPNGBDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  139nM ΔG°:  -40.7kJ/molepH: 7.4 T: 2°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain [D597N](Rat)
University of California Irvine

LigandPNGBDBM190666(nNOS inhibitor, 4 | US10759791, Compound 14h)
Affinity DataKi:  641nM ΔG°:  -36.8kJ/molepH: 7.4 T: 2°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain [D597N](Rat)
University of California Irvine

LigandPNGBDBM190665(nNOS inhibitor, 3 | US10759791, Compound 14g)
Affinity DataKi:  748nM ΔG°:  -36.4kJ/molepH: 7.4 T: 2°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain [D597N](Rat)
University of California Irvine

LigandPNGBDBM21961(JMC522060 Compound 3 | (2S,4R)-4-[(2S)-2-amino-5-(...)
Affinity DataKi:  2.10E+4nM ΔG°:  -27.1kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, brain [D597N](Rat)
University of California Irvine

LigandPNGBDBM21960(JMC522060 Compound 2 | CHEMBL227937 | 3-[(4S)-4-am...)
Affinity DataKi:  3.40E+4nM ΔG°:  -25.9kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, brain [D597N](Rat)
University of California Irvine

LigandPNGBDBM22030(CHEMBL481413 | CHEMBL1204421 | L-N(OMEGA)-NITROARG...)
Affinity DataKi:  6.70E+4nM ΔG°:  -24.2kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed