Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with Target = 'Neuronal acetylcholine receptor subunit alpha-6'
TargetNeuronal acetylcholine receptor subunit alpha-6/beta-2(Human)
Boise State University

Curated by ChEMBL
LigandPNGBDBM50481208(CHEMBL594330)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of alpha6beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50334463(1,3,5-tri-{5-[1-(3-picolinium)]-pent-1-ynyl}benzen...)
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6/beta-2(Human)
Boise State University

Curated by ChEMBL
LigandPNGBDBM50481207(CHEMBL595286)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of alpha6beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50334472(1,3,5-tris(5-(3,4-dihydroisoquinolin-2(1H)-yl)pent...)
Affinity DataIC50: 0.350nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6/beta-2(Human)
Boise State University

Curated by ChEMBL
LigandPNGBDBM50481206(CHEMBL595311)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of alpha6beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6/beta-2(Human)
Boise State University

Curated by ChEMBL
LigandPNGBDBM50481209(CHEMBL595047)
Affinity DataIC50: 0.950nMAssay Description:Inhibition of alpha6beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50334464(1,12-bis(3-methyl-5,6-dihydropyridin-1(2H)-yl)dode...)
Affinity DataIC50: 0.950nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50119774(N,N'-(1,12-dodecandiyl)-bis-pyridinium dibromide |...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at nAChR-alpha-6-beta-2 in Sprague-Dawley rat striatal slices assessed as inhibition of nicotine-evoked [3H]dopamine uptake by li...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50119774(N,N'-(1,12-dodecandiyl)-bis-pyridinium dibromide |...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50334474(1,1',1'',1'''-(5,5',5'',5'''-(benzene-1,2,4,5-tetr...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6/beta-2(Human)
Boise State University

Curated by ChEMBL
LigandPNGBDBM50481212(CHEMBL609593)
Affinity DataIC50: 3nMAssay Description:Inhibition of alpha6beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50334466(1,3,5-tris(5-(3-methyl-5,6-dihydropyridin-1(2H)-yl...)
Affinity DataIC50: 3.22nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50334470(1,12-bis(3,4-dihydroisoquinolin-2(1H)-yl)dodecane ...)
Affinity DataIC50: 8.59nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50334471(1,10-bis(3,4-dihydroisoquinolin-2(1H)-yl)decane | ...)
Affinity DataIC50: 9.91nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6/beta-4(Rat)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50516340(CHEMBL4439678)
Affinity DataIC50: 17nMAssay Description:Inhibition of rat alpha6beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response measured aft...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6/beta-4(Rat)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50567426(CHEMBL4878856)
Affinity DataIC50: 23nMAssay Description:Inhibition of rat alpha6beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response measured aft...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6/beta-4(Rat)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50567413(CHEMBL4865365)
Affinity DataIC50: 27nMAssay Description:Inhibition of rat alpha6beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response measured aft...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50334475(3,3',3'',3'''-(1,1',1'',1'''-(5,5',5'',5'''-(benze...)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50334465(1,10-bis(3-methyl-5,6-dihydropyridin-1(2H)-yl)deca...)
Affinity DataIC50: 37.4nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50119805(1,12-di(2-isoquinoliniumyl)dodecane; with dibromid...)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6/beta-4(Rat)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50516342(CHEMBL4461998)
Affinity DataIC50: 50nMAssay Description:Inhibition of rat alpha6beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response measured aft...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50334469(2,2',2'',2'''-(5,5',5'',5'''-(benzene-1,2,4,5-tetr...)
Affinity DataIC50: 56nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50334467(1,2-bis-(5-isoquinolinium-pent-1-ynyl)benzene dibr...)
Affinity DataIC50: 63nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50119780(CHEMBL105538 | 1,10-di(2-isoquinoliniumyl)decane; ...)
Affinity DataIC50: 70nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6/beta-4(Rat)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50445326(CHEMBL3104239)
Affinity DataIC50: 130nMAssay Description:Antagonist activity at rat alpha6beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding pot...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50119782(CHEMBL1643939 | 1,1''-(decane-1,10-diyl)bis(3-meth...)
Affinity DataIC50: 180nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6/beta-2(Human)
Boise State University

Curated by ChEMBL
LigandPNGBDBM50481210(CHEMBL609594)
Affinity DataIC50: 201nMAssay Description:Inhibition of alpha6beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50334473(1,2,4,5-tetrakis(5-(3,4-dihydroisoquinolin-2(1H)-y...)
Affinity DataIC50: 205nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6/beta-4(Rat)
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50445326(CHEMBL3104239)
Affinity DataIC50: 222nMAssay Description:Inhibition of rat alpha6beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response measured aft...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50263130((+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-3-yl)-5'...)
Affinity DataKi:  0.0210nMAssay Description:Displacement of [3H]epibatidine from rat alpha6beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50263095((+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-4-yl)-5'...)
Affinity DataKi:  0.0310nMAssay Description:Displacement of [3H]epibatidine from rat alpha6beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50263171((+)-2-(6'-[18F]fluoro-3,3'-bipyridin-5-yl)-7-methy...)
Affinity DataKi:  0.0470nMAssay Description:Displacement of [3H]epibatidine from rat alpha6beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50263131((+)-7-Methyl-2-exo-[3'-(6-fluoropyridin-2-yl)-5'-p...)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]epibatidine from rat alpha6beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Chicken)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM50004108((R,S)-nicotine | (RS)-nicotine | nicotine | (+-)-n...)
Affinity DataKi:  20nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Chicken)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM86240(Gly-L-Cys(1)-L-Cys(2)-L-Ser-L-Asn-L-Pro-L-Val-L-Cy...)
Affinity DataKi:  66nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50045045(CHEMBL3341965)
Affinity DataKi: >300nMAssay Description:Partial agonist activity at rat alpha6 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Chicken)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM86241(NSC_31762 | CAS_23255-54-1 | Dihydro-Beta-erythroi...)
Affinity DataKi:  2.80E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Chicken)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM86243(CAS_17360 | NSC_17360 | MG624)
Affinity DataKi:  4.52E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Chicken)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM86242(CAS_64645 | NSC_64645 | Tubocurarine,d)
Affinity DataKi:  7.70E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Chicken)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM50038416(Hexamethoniumdibromide | N,N,N,N'',N'',N''-Hexamet...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Chicken)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed