Compile Data Set for Download or QSAR
Report error Found 273 Enz. Inhib. hit(s) with Target = 'Neuronal acetylcholine receptor subunit alpha-4/beta-4'
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50071366(7-Methoxy-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-h...)
Affinity DataEC50:  3.20E+4nMAssay Description:Compound was evaluated for its agonist activity against activated human recombinant Nicotinic acetylcholine receptor alpha4-beta4 in Xenopus OocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  7.10E+3nMAssay Description:The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataEC50:  9.00E+3nMAssay Description:The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataEC50:  9.00E+3nMAssay Description:The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM86544(NSC_6442277 | CAS_192231-16-6 | CHEMBL111580 | SIB...)
Affinity DataEC50:  2.30E+4nMAssay Description:The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM86544(NSC_6442277 | CAS_192231-16-6 | CHEMBL111580 | SIB...)
Affinity DataEC50:  2.50E+4nMAssay Description:The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100715(2-(6-Bromo-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hepta...)
Affinity DataEC50:  20nMAssay Description:Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataEC50:  17nMAssay Description:Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;perchlorate | 2-...)
Affinity DataEC50:  1.90E+4nMAssay Description:Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100713(5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-pyridin-2-ylamin...)
Affinity DataEC50:  1.84E+3nMAssay Description:Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100717(2-(pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane | CHE...)
Affinity DataEC50:  982nMAssay Description:Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100707((R)-2-(6-Fluoro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]...)
Affinity DataEC50:  239nMAssay Description:Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50459884(CHEMBL4228846)
Affinity DataEC50:  237nMAssay Description:Positive allosteric modulation of human alpha4beta4 nAChR expressed in HEK cells preincubated for 15 mins followed by dihydro-beta-erythroidine hydro...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKd:  0.0900nMAssay Description:Tested for binding affinity against Nicotinic acetylcholine receptor alpha4-beta4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50341208((S,S)-2-(3'-Chlorophenyl)-3,5,5-trimethyl-4-propyl...)
Affinity DataIC50: 5.80E+3nMAssay Description:Antagonist activity at human alpha4beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion effluxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50341207((S,S)-2-(3'-Chlorophenyl)-4-ethyl-3,5,5-trimethylm...)
Affinity DataIC50: 6.40E+3nMAssay Description:Antagonist activity at human alpha4beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion effluxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322512((2S,3S)-2-(3-Chlorophenyl)-5,5-dimethyl-3-propyl-m...)
Affinity DataIC50: 8.00E+3nMAssay Description:Antagonist activity at human alpha4beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion effluxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322520((2S,3S)-2-Biphenyl-4-yl-3,5,5-trimethylmorpholin-2...)
Affinity DataIC50: 8.10E+3nMAssay Description:Antagonist activity at alpha4beta4 nicotinic receptor in human SH-EP1 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50238584(CHEMBL4089797)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at rat alpha4beta4 nACHR expressed in xenopous laevis oocyte assessed as inhibition of ACh induced channel current after 5 mins a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50459652(CHEMBL4215824)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at rat alpha4beta4 nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50567433(CHEMBL4869892)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat alpha4beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-elect...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50567435(CHEMBL4872191)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat alpha4beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-elect...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50567436(CHEMBL4867647)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat alpha4beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-elect...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50567437(CHEMBL4871260)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat alpha4beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-elect...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50567438(CHEMBL4865866)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat alpha4beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-elect...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50587081(CHEMBL5087526)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at rat alpha4beta4 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50587080(CHEMBL5081410)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at rat alpha4beta4 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50587082(CHEMBL5076584)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at rat alpha4beta4 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50587083(CHEMBL5077936)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at rat alpha4beta4 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50587089(CHEMBL5089119)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at rat alpha4beta4 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50606633(CHEMBL5219936)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human alpha4beta4 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and me...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50606633(CHEMBL5219936)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat alpha4beta4 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and meas...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322514((2S,3S)-2-(Naphthalen-2-yl)-3,5,5-trimethylmorphol...)
Affinity DataIC50: 1.10E+4nMAssay Description:Antagonist activity at alpha4beta4 nicotinic receptor in human SH-EP1 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322528((2S,3S)-2-(3-Bromophenyl)-3,5,5-trimethylmorpholin...)
Affinity DataIC50: 1.10E+4nMAssay Description:Antagonist activity at human alpha4beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion effluxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50048392(BUPROPION HYDROCHLORIDE | CHEMBL894 | 2-(tert-buty...)
Affinity DataIC50: 1.20E+4nMAssay Description:Antagonist activity at alpha4beta4 nicotinic receptor in human SH-EP1 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322531((2R,3R)-2-(3-Chlorophenyl)-3,5,5-trimethylmorpholi...)
Affinity DataIC50: 1.20E+4nMAssay Description:Antagonist activity at human alpha4beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion effluxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322515((2S,3S)-2-(Naphthalen-1-yl)-3,5,5-trimethylmorphol...)
Affinity DataIC50: 1.30E+4nMAssay Description:Antagonist activity at alpha4beta4 nicotinic receptor in human SH-EP1 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322518((+/-)2-(3,4-Dichlorophenyl)-3,5,5-trimethylmorphol...)
Affinity DataIC50: 1.40E+4nMAssay Description:Antagonist activity at alpha4beta4 nicotinic receptor in human SH-EP1 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322513((2S,3S)-2-(3-Chlorophenyl)-3-ethyl-5,5-dimethylmor...)
Affinity DataIC50: 1.50E+4nMAssay Description:Antagonist activity at human alpha4beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion effluxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322513((2S,3S)-2-(3-Chlorophenyl)-3-ethyl-5,5-dimethylmor...)
Affinity DataIC50: 1.60E+4nMAssay Description:Antagonist activity at alpha4beta4 nicotinic receptor in human SH-EP1 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322512((2S,3S)-2-(3-Chlorophenyl)-5,5-dimethyl-3-propyl-m...)
Affinity DataIC50: 1.80E+4nMAssay Description:Antagonist activity at alpha4beta4 nicotinic receptor in human SH-EP1 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322516((+/-)2-(3,5-Dichlorophenyl)-3,5,5-trimethylmorphol...)
Affinity DataIC50: 1.80E+4nMAssay Description:Antagonist activity at alpha4beta4 nicotinic receptor in human SH-EP1 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322511((2S,3S)-2-(3-Chlorophenyl)-3,4,5,5-tetramethylmorp...)
Affinity DataIC50: 2.30E+4nMAssay Description:Antagonist activity at human alpha4beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion effluxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322531((2R,3R)-2-(3-Chlorophenyl)-3,5,5-trimethylmorpholi...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at alpha4beta4 nicotinic receptor in human SH-EP1 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322528((2S,3S)-2-(3-Bromophenyl)-3,5,5-trimethylmorpholin...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at alpha4beta4 nicotinic receptor in human SH-EP1 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322532((2S,3S)-2-(3-Chlorophenyl)-3,5,5-trimethylmorpholi...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human alpha4beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion effluxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322523((2S,3S)-2-(4-Chlorophenyl)-3,5,5-trimethylmorpholi...)
Affinity DataIC50: 3.30E+4nMAssay Description:Antagonist activity at alpha4beta4 nicotinic receptor in human SH-EP1 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322532((2S,3S)-2-(3-Chlorophenyl)-3,5,5-trimethylmorpholi...)
Affinity DataIC50: 4.10E+4nMAssay Description:Antagonist activity at alpha4beta4 nicotinic receptor in human SH-EP1 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322511((2S,3S)-2-(3-Chlorophenyl)-3,4,5,5-tetramethylmorp...)
Affinity DataIC50: 4.30E+4nMAssay Description:Antagonist activity at alpha4beta4 nicotinic receptor in human SH-EP1 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Human)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM50322529((2S,3S)-2-(3-Fluorophenyl)-3,5,5-trimethylmorpholi...)
Affinity DataIC50: 5.50E+4nMAssay Description:Antagonist activity at human alpha4beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion effluxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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