Compile Data Set for Download or QSAR
Report error Found 86 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 10/8/9'
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM86636(JNK-IN-11)
Affinity DataEC50:  8.60nMAssay Description:Inhibition of c-Jun phosphorylation in human A-375 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM86636(JNK-IN-11)
Affinity DataEC50:  48nMAssay Description:Inhibition of c-Jun phosphorylation in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50492032(CHEMBL2392831)
Affinity DataIC50: 104nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM102560(US8536172, I-9)
Affinity DataIC50: 200nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM102604(US8536172, I-53)
Affinity DataIC50: 220nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM102563(US8536172, I-12)
Affinity DataIC50: 240nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM102617(US8536172, I-66)
Affinity DataIC50: 290nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50492031(CHEMBL2392839)
Affinity DataIC50: 420nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506722(CHEMBL4439862)
Affinity DataIC50: 500nMAssay Description:Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506715(CHEMBL4449918)
Affinity DataIC50: 600nMAssay Description:Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM102569(US8536172, I-18)
Affinity DataIC50: 650nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM102564(US8536172, I-13)
Affinity DataIC50: 700nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM29315(2-amino-1,3,4-thiadiazole, 9)
Affinity DataIC50: 700nMAssay Description:Inhibition of JNK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM102557(US8536172, I-6)
Affinity DataIC50: 710nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM102562(US8536172, I-11)
Affinity DataIC50: 820nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506716(CHEMBL4521282)
Affinity DataIC50: 900nMAssay Description:Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of c-Jun N-terminal kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50492029(CHEMBL2390974)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506712(CHEMBL4583031)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM102568(US8536172, I-17)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM317462(US9623028, Compound 38 | 4-(4-(cyclopentyloxy)-5-(...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of JNK1/JNK2/JNK3 in human HCT116 cell lysate after 1 hr by LC-MS/MS analysis relative to controlMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM102571(US8536172, I-20)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50102624(CHEMBL1234032)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of JNK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM102616(US8536172, I-65)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506720(CHEMBL4514173)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506717(CHEMBL3759098)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506721(CHEMBL4582239)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506723(CHEMBL4474210)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506715(CHEMBL4449918)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506722(CHEMBL4439862)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506723(CHEMBL4474210)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506718(CHEMBL1098827)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506721(CHEMBL4582239)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506719(CHEMBL4457644)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506725(CHEMBL4593099)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506718(CHEMBL1098827)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506717(CHEMBL3759098)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506716(CHEMBL4521282)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506725(CHEMBL4593099)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506724(CHEMBL4536915)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506720(CHEMBL4514173)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506712(CHEMBL4583031)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506724(CHEMBL4536915)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506726(CHEMBL4524938)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506719(CHEMBL4457644)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50506726(CHEMBL4524938)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50183831(4-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50183860((R)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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