Compile Data Set for Download or QSAR
Report error Found 74 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 1/3'
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28123(CHEMBL318804 | 4-({3-chloro-4-[(1-methyl-1H-imidaz...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibit ion of MAPK phosphorylation in LoVo cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505988(CHEMBL4482864)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of ERK1/2 phosphorylation in human A375 cells harboring BRAF V600E mutant after 4 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505994(CHEMBL4440109)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of ERK1/2 in human A375 cells harboring BRAF V600E mutant assessed as suppression of RSK phosphorylation after 4 hrs by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505992(CHEMBL4452853)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505988(CHEMBL4482864)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505990(CHEMBL4458562)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505991(CHEMBL4470113)
Affinity DataIC50: 10nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265959(CHEMBL4071576)
Affinity DataIC50: 12nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505992(CHEMBL4452853)
Affinity DataIC50: 12nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: 12nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50: 16nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505993(CHEMBL4587118)
Affinity DataIC50: 20nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50419256(CHEMBL1835065 | US9579320, Example 302)
Affinity DataIC50: 20nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505989(CHEMBL4551714)
Affinity DataIC50: 30nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM120095(US8697715, 39 | US9259470, 39 | US10525036, Exampl...)
Affinity DataIC50: 31nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505990(CHEMBL4458562)
Affinity DataIC50: 31nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505994(CHEMBL4440109)
Affinity DataIC50: 38nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505989(CHEMBL4551714)
Affinity DataIC50: 60nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265959(CHEMBL4071576)
Affinity DataIC50: 62nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50419265(CHEMBL1835069)
Affinity DataIC50: 63nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50419247(CHEMBL1835071 | US8470835, 1)
Affinity DataIC50: 79nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50419258(CHEMBL1835070)
Affinity DataIC50: 79nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM120095(US8697715, 39 | US9259470, 39 | US10525036, Exampl...)
Affinity DataIC50: 86nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50419259(CHEMBL1835072)
Affinity DataIC50: 126nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50419260(CHEMBL1834758)
Affinity DataIC50: 126nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50094465(CHEMBL3590106 | US10525036, Example BVD-523 | US10...)
Affinity DataIC50: 150nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50419250(CHEMBL1834757)
Affinity DataIC50: 158nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50419253(CHEMBL1835061)
Affinity DataIC50: 200nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50586289(CHEMBL5070887)
Affinity DataIC50: 224nMAssay Description:Inhibition of ERK1/2 in human COLO 205 cells assessed as inhibition of RSK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50419262(CHEMBL1835068)
Affinity DataIC50: 316nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50419255(CHEMBL1835064)
Affinity DataIC50: 316nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50095232(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenox...)
Affinity DataIC50: 380nMAssay Description:Inhibit ion of MAPK phosphorylation in LoVo cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50456353(CHEMBL4210682 | US11001575, Example 2)
Affinity DataIC50: 630nMAssay Description:Inhibition of ERK1/2 in human A375 cells harboring BRAF V600E mutant assessed as suppression of RSK phosphorylation after 4 hrs by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM237225(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Affinity DataIC50: 1.27E+3nMAssay Description:Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50419251(CHEMBL1835058)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of Dual specificity mitogen-activated protein kinase kinase (MEK)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM237214(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Affinity DataIC50: 2.14E+3nMAssay Description:Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50094465(CHEMBL3590106 | US10525036, Example BVD-523 | US10...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM237223(1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Affinity DataIC50: 3.12E+3nMAssay Description:Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM237222(1-(4-Hydroxy-3-methoxybenzyl)-1-(4-methoxyphenyl)-...)
Affinity DataIC50: 3.21E+3nMAssay Description:Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM237224(1-(4-Chlorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Affinity DataIC50: 3.28E+3nMAssay Description:Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM237220(1-(4-Hydroxy-3-methoxybenzyl)-1, 3-diphenylthioure...)
Affinity DataIC50: 3.35E+3nMAssay Description:Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM237213(1-(4-Chlorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Affinity DataIC50: 4.07E+3nMAssay Description:Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM237230(1-(2, 4-Dichlorophenyl)-1-(4-hydroxy-3-methoxybenz...)
Affinity DataIC50: 4.13E+3nMAssay Description:Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM237212(1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Affinity DataIC50: 4.19E+3nMAssay Description:Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM237219(1-(2, 4-Dichlorophenyl)-1-(4-hydroxy-3-methoxybenz...)
Affinity DataIC50: 5.22E+3nMAssay Description:Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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