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Report error Found 1569 Enz. Inhib. hit(s) with Target = 'Mineralocorticoid receptor'
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50417616(CHEMBL1645403)
Affinity DataEC50: >1.00E+4nMAssay Description:Antagonist activity at human MR ligand binding domain transfected in CHO cells co-transfected with MMTV-luciferase gene assessed as inhibition of cor...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM8903(CHEMBL103 | (1S,2R,10S,11S,14S,15S)-14-acetyl-2,15...)
Affinity DataKd:  0.390nMAssay Description:Affinity for recombinant Mineralocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19214([3H]Aldosterone | (1S,2R,10S,11S,14S,15R,17S)-17-h...)
Affinity DataEC50:  0.180nMAssay Description:Agonist activity at human MCR expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50048339(CHEMBL3315061)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at mineralocorticoid receptor in human A549 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50048340(CHEMBL3315062)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at mineralocorticoid receptor in human A549 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50298028(2-chloro-4-{[(3S)-1-methylpyrrolidin-3-yl][2-(trif...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at MR expressed in african green monkey CV-1 cells by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323524(4-(((6-((3-(2,6-dichlorophenyl)-5-isopropylisoxazo...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mineralocorticoid receptor-LBD expressed in HEK293 cells assessed as Gal4-DBD interaction by cellular mammalian one hybrid assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323530(3-(((6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxa...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mineralocorticoid receptor-LBD expressed in HEK293 cells assessed as Gal4-DBD interaction by cellular mammalian one hybrid assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323533(4-(((6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxa...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mineralocorticoid receptor-LBD expressed in HEK293 cells assessed as Gal4-DBD interaction by cellular mammalian one hybrid assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50353386(US8592410, 88 | CHEMBL1829763 | US8598163, 61 | US...)
Affinity DataEC50: >5.00E+3nMAssay Description:Binding affinity to MRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataEC50:  0.00200nMAssay Description:Agonist activity at human mineralocorticoid receptor expressed in human A549 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50355735(CHEMBL1911270)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human mineralocorticoid receptor expressed in human A549 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50355730(CHEMBL1911274)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human mineralocorticoid receptor expressed in human A549 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50355740(CHEMBL1911272)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human mineralocorticoid receptor expressed in human A549 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348415(CHEMBL1800985)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human mineralocorticoid receptor expressed in human A549 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348401(CHEMBL1801012)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human mineralocorticoid receptor expressed in human A549 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442531(11BETA-HYDROXYPROGESTERONE)
Affinity DataEC50:  50nMAssay Description:Transactivation of wild-type human recombinant mineralocorticoid receptor expressed in COS7 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442534(CHEMBL2440896)
Affinity DataEC50:  4.10E+3nMAssay Description:Transactivation of human recombinant mineralocorticoid receptor expressed in HEK-293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442531(11BETA-HYDROXYPROGESTERONE)
Affinity DataEC50:  1.40E+4nMAssay Description:Transactivation of human recombinant mineralocorticoid receptor expressed in HEK-293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440242(CHEMBL2426663)
Affinity DataEC50: >5.00E+6nMAssay Description:Agonist activity at mineralocorticoid receptor in human A549 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440243(CHEMBL2426662)
Affinity DataEC50: >5.00E+6nMAssay Description:Agonist activity at mineralocorticoid receptor in human A549 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50407856(CHEMBL2112398)
Affinity DataKd:  20nMAssay Description:Affinity for recombinant Mineralocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50407855(CHEMBL2112397)
Affinity DataKd:  20nMAssay Description:Affinity for recombinant Mineralocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50422147(CHEMBL97531)
Affinity DataKd:  0.740nMAssay Description:Affinity for recombinant Mineralocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19214([3H]Aldosterone | (1S,2R,10S,11S,14S,15R,17S)-17-h...)
Affinity DataEC50:  3.80nMAssay Description:Agonist activity at mineralocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM18627(Mifeprex | (10S,11S,14S,15S,17R)-17-[4-(dimethylam...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc after 24 hrs by lucifer...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50415790(GSK-1564023A | CHEMBL1093774 | US10272074, Example...)
Affinity DataEC50: >2.00E+4nMAssay Description:Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50415792(CHEMBL1089743)
Affinity DataEC50: >1.00E+4nMAssay Description:Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50415794(GSK-325971A | CHEMBL1093602)
Affinity DataEC50: >1.00E+4nMAssay Description:Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50415796(CHEMBL1089350)
Affinity DataEC50: >1.00E+4nMAssay Description:Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19214([3H]Aldosterone | (1S,2R,10S,11S,14S,15R,17S)-17-h...)
Affinity DataEC50:  0.338nMAssay Description:Agonist activity at mineralocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity aft...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50412519(CHEMBL455662)
Affinity DataEC50: >1.00E+4nMAssay Description:Binding affinity to mineralocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at mineralocorticoid receptor in human A549 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348401(CHEMBL1801012)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at mineralocorticoid receptor in human A549 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348405(CHEMBL1801008)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at mineralocorticoid receptor in human A549 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348407(CHEMBL1801006)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at mineralocorticoid receptor in human A549 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348411(CHEMBL1800981)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at mineralocorticoid receptor in human A549 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348415(CHEMBL1800985)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at mineralocorticoid receptor in human A549 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348414(CHEMBL1800984)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at mineralocorticoid receptor in human A549 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50321176(rac-3-(4-Nitrophenylamino)-3-(3-fluorophenyl)-1-p-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc after 24 hrs by lucifer...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19214([3H]Aldosterone | (1S,2R,10S,11S,14S,15R,17S)-17-h...)
Affinity DataEC50:  0.470nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM323679(US10188667, Example 00020 | US10188667, Example 00...)
Affinity DataEC50:  2.85nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM13775([3H]cortisol | (1S,2R,10S,11S,14R,15S,17S)-14,17-d...)
Affinity DataEC50:  2.90nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM323672(US10188667, Example 00024 | US10188667, Example 00...)
Affinity DataEC50:  2.94nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM323675(US10188667, Example 00025 | US10188667, Example 00...)
Affinity DataEC50:  3.17nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM323674(US10188667, Example 00029 | US10188667, Example 00...)
Affinity DataEC50:  5.27nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM323673(US10188667, Example 00027 | US10188667, Example 00...)
Affinity DataEC50:  5.68nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM323671(US10188667, Example 00012 | US10188667, Example 00...)
Affinity DataEC50:  7.46nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM323674(US10188667, Example 00029 | US10188667, Example 00...)
Affinity DataEC50:  9.29nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM323676(US10188667, Example 00030 | US10188667, Example 00...)
Affinity DataEC50:  15.6nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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