Compile Data Set for Download or QSAR
Report error Found 120 Enz. Inhib. hit(s) with Target = 'Methylated-DNA--protein-cysteine methyltransferase'
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50093336(6-(Thiophen-2-yloxy)-9H-purin-2-ylamine | CHEMBL33...)
Affinity DataIC50: 3nMAssay Description:Inhibition of AGT activity to 50% of control rate in HT-29 cell extractMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50106517(6-(4-Bromo-thiophen-2-ylmethoxy)-9H-purin-2-ylamin...)
Affinity DataIC50: 3nMAssay Description:Inactivation of human O-6-methylguanine-DNA methyltransferase assessed as [3H]methylated protein formation by liquid scintillation counting in presen...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068794(6-(5-Bromo-thiophen-2-ylmethoxy)-6,9-dihydro-1H-pu...)
Affinity DataIC50: 5nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50106517(6-(4-Bromo-thiophen-2-ylmethoxy)-9H-purin-2-ylamin...)
Affinity DataIC50: 9nMAssay Description:In vitro inhibition of MGMT using cell free extracts from HeLa S3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50397045(CHEMBL485756)
Affinity DataIC50: 9nMAssay Description:Inhibition of AGT in human HL60 cells assessed as AGT levels using [3H]AGT after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068794(6-(5-Bromo-thiophen-2-ylmethoxy)-6,9-dihydro-1H-pu...)
Affinity DataIC50: 10nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068792(6-(Thiophen-2-ylmethoxy)-6,9-dihydro-1H-purin-2-yl...)
Affinity DataIC50: 18nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50397044(CHEMBL2171205)
Affinity DataIC50: 25nMAssay Description:Inhibition of AGT in human HL60 cells assessed as AGT levels using [3H]AGT after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068792(6-(Thiophen-2-ylmethoxy)-6,9-dihydro-1H-purin-2-yl...)
Affinity DataIC50: 30nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50106510(2-{12-[2-Amino-6-(4-bromo-thiophen-2-ylmethoxy)-pu...)
Affinity DataIC50: 30nMAssay Description:In vitro inhibition of MGMT using cell free extracts from HeLa S3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50106518(2-{10-[2-Amino-6-(4-bromo-thiophen-2-ylmethoxy)-pu...)
Affinity DataIC50: 30nMAssay Description:In vitro inhibition of MGMT using cell free extracts from HeLa S3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50106511(2-{8-[2-Amino-6-(4-bromo-thiophen-2-ylmethoxy)-pur...)
Affinity DataIC50: 32nMAssay Description:In vitro inhibition of MGMT using cell free extracts from HeLa S3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068785(6-(Thiazol-5-ylmethoxy)-6,9-dihydro-1H-purin-2-yla...)
Affinity DataIC50: 33nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50106515(7-Benzyloxy-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-y...)
Affinity DataIC50: 38nMAssay Description:In vitro inhibition of MGMT using cell free extracts from HeLa S3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50: 39nMAssay Description:Inhibition of AGT in human HL60 cells assessed as AGT levels using [3H]AGT after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068786(6-(2-Chloro-pyridin-4-ylmethoxy)-6,9-dihydro-1H-pu...)
Affinity DataIC50: 40nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50: 40nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068786(6-(2-Chloro-pyridin-4-ylmethoxy)-6,9-dihydro-1H-pu...)
Affinity DataIC50: 50nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50062823(6-(4-Fluoro-benzyloxy)-5-nitroso-pyrimidine-2,4-di...)
Affinity DataIC50: 51nMAssay Description:In vitro inhibitory activity against human O6-alkylguanine-DNA alkyltransferase (AGAT)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50: 58nMAssay Description:concentration required to reduce AGT activity to 50% of control rate in intact HT-29 human colorectal carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068785(6-(Thiazol-5-ylmethoxy)-6,9-dihydro-1H-purin-2-yla...)
Affinity DataIC50: 60nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068784(6-(Isothiazol-4-ylmethoxy)-6,9-dihydro-1H-purin-2-...)
Affinity DataIC50: 70nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068784(6-(Isothiazol-4-ylmethoxy)-6,9-dihydro-1H-purin-2-...)
Affinity DataIC50: 70nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068783(6-(Furan-2-ylmethoxy)-6,9-dihydro-1H-purin-2-ylami...)
Affinity DataIC50: 80nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50397043(CHEMBL2171202)
Affinity DataIC50: 86nMAssay Description:Inhibition of AGT in human HL60 cells assessed as AGT levels using [3H]AGT after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068789(6-([1,3]Dioxolo[4,5-b]pyridin-6-ylmethoxy)-6,9-dih...)
Affinity DataIC50: 90nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50: 100nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068793(6-(6-Chloro-pyridin-3-ylmethoxy)-6,9-dihydro-1H-pu...)
Affinity DataIC50: 120nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068783(6-(Furan-2-ylmethoxy)-6,9-dihydro-1H-purin-2-ylami...)
Affinity DataIC50: 120nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM5573(CHEMBL71484 | 6-(benzyloxy)-5-nitrosopyrimidine-2,...)
Affinity DataIC50: 130nMAssay Description:In vitro inhibitory activity against human O6-alkylguanine-DNA alkyltransferase (AGAT)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068780(6-(Pyridin-4-ylmethoxy)-6,9-dihydro-1H-purin-2-yla...)
Affinity DataIC50: 130nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50: 180nMAssay Description:Inhibition of AGT activity to 50% of control rate in HT-29 cell extractMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068780(6-(Pyridin-4-ylmethoxy)-6,9-dihydro-1H-purin-2-yla...)
Affinity DataIC50: 200nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068788(6-(5-Bromo-pyridin-3-ylmethoxy)-6,9-dihydro-1H-pur...)
Affinity DataIC50: 200nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM5484(6-(cyclopent-1-en-1-ylmethoxy)-9H-purin-2-amine | ...)
Affinity DataIC50: 200nMAssay Description:concentration required to reduce AGT activity to 50% of control rate in intact HT-29 human colorectal carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068793(6-(6-Chloro-pyridin-3-ylmethoxy)-6,9-dihydro-1H-pu...)
Affinity DataIC50: 200nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068781(6-(Oxazol-5-ylmethoxy)-6,9-dihydro-1H-purin-2-ylam...)
Affinity DataIC50: 220nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068791(6-(Pyridin-3-ylmethoxy)-6,9-dihydro-1H-purin-2-yla...)
Affinity DataIC50: 220nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068789(6-([1,3]Dioxolo[4,5-b]pyridin-6-ylmethoxy)-6,9-dih...)
Affinity DataIC50: 230nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50062816(5-Nitroso-6-(pyridin-4-ylmethoxy)-pyrimidine-2,4-d...)
Affinity DataIC50: 230nMAssay Description:In vitro inhibitory activity against human O6-alkylguanine-DNA alkyltransferase (AGAT)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50106514(2-{4-[2-Amino-6-(4-bromo-thiophen-2-ylmethoxy)-pur...)
Affinity DataIC50: 250nMAssay Description:In vitro inhibition of MGMT using cell free extracts from HeLa S3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068788(6-(5-Bromo-pyridin-3-ylmethoxy)-6,9-dihydro-1H-pur...)
Affinity DataIC50: 250nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50338477(6-((4-bromothiophen-2-yl)methoxy)-5-nitropyrimidin...)
Affinity DataIC50: 320nMAssay Description:Inactivation of human O-6-methylguanine-DNA methyltransferase assessed as [3H]methylated protein formation by liquid scintillation counting in presen...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50062815(6-(4-Fluoro-benzyloxy)-5-nitro-pyrimidine-2,4-diam...)
Affinity DataIC50: 350nMAssay Description:In vitro inhibitory activity against human O6-alkylguanine-DNA alkyltransferase (AGAT)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068781(6-(Oxazol-5-ylmethoxy)-6,9-dihydro-1H-purin-2-ylam...)
Affinity DataIC50: 350nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM5484(6-(cyclopent-1-en-1-ylmethoxy)-9H-purin-2-amine | ...)
Affinity DataIC50: 390nMAssay Description:Inhibition of AGT activity to 50% of control rate in HT-29 cell extractMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068791(6-(Pyridin-3-ylmethoxy)-6,9-dihydro-1H-purin-2-yla...)
Affinity DataIC50: 430nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50106512(2-{6-[2-Amino-6-(4-bromo-thiophen-2-ylmethoxy)-pur...)
Affinity DataIC50: 450nMAssay Description:In vitro inhibition of MGMT using cell free extracts from HeLa S3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50106513(2-{4-[2-Amino-6-(4-bromo-thiophen-2-ylmethoxy)-pur...)
Affinity DataIC50: 450nMAssay Description:In vitro inhibition of MGMT using cell free extracts from HeLa S3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50093328(6-(Cyclobut-1-enylmethoxy)-9H-purin-2-ylamine | CH...)
Affinity DataIC50: 550nMAssay Description:Inhibition of AGT activity to 50% of control rate in HT-29 cell extractMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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