Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with Target = 'Membrane-bound transcription factor site-1 protease'
LigandPNGBDBM50216194(N-(2-chlorophenethyl)-N-(pyrrolidin-3-yl)-4-((3-o-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216201(N-(2-methoxyphenethyl)-4-(6-aza-bicyclo[3.2.1]octa...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216180(N-(2-methoxyphenethyl)-N-(pyrrolidin-3-yl)-4-((3-o...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216199(4-(2-aza-bicyclo[2.2.1]heptan-2-ylmethyl)-N-(2-met...)
Affinity DataIC50: 95nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216188(N-(2-methoxyphenethyl)-4-(((1S,2S)-2-hydroxycycloh...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216193(N-(2-methoxyphenethyl)-4-(((S)-2-(methoxymethyl)py...)
Affinity DataIC50: 140nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216197(N-(2-methoxyphenethyl)-4-(((S)-2-(methoxymethyl)py...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216181(PF-429242 | (R)-N-(2-methoxyphenethyl)-4-((diethyl...)
Affinity DataIC50: 170nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216204(N-(2-methoxyphenethyl)-4-(piperidin-1-ylmethyl)-N-...)
Affinity DataIC50: 250nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216206(N-(2-methoxyphenethyl)-4-(benzyloxy)-N-(pyrrolidin...)
Affinity DataIC50: 310nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216191(N-(2,6-dichlorophenethyl)-4-((diethylamino)methyl)...)
Affinity DataIC50: 430nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216187(N-(3-chlorophenethyl)-4-(benzyloxy)-N-(pyrrolidin-...)
Affinity DataIC50: 510nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216196(N-(2-methoxyphenethyl)-4-((diethylamino)methyl)-N-...)
Affinity DataIC50: 540nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216183(N-(2-chlorophenethyl)-4-(benzyloxy)-N-(pyrrolidin-...)
Affinity DataIC50: 590nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216207(N-(2-chlorophenethyl)-4-((diethylamino)methyl)-N-(...)
Affinity DataIC50: 840nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216208((S)-N-(2-methoxyphenethyl)-4-((diethylamino)methyl...)
Affinity DataIC50: 970nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216186(N-(2-chlorophenethyl)-4-isopropoxy-N-(pyrrolidin-3...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216203(4-diethylaminomethyl-N-pyrrolidin-3-yl-N-(2-o-toly...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216190(N-(4-chlorophenethyl)-4-((diethylamino)methyl)-N-(...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216205(N-(2-chlorobenzyl)-4-isopropoxy-N-(pyrrolidin-3-yl...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216184(N-(2-fluorophenethyl)-4-isopropoxy-N-(pyrrolidin-3...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216189(N-(3-chlorophenethyl)-4-isopropoxy-N-(pyrrolidin-3...)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216182(N-(2-ethoxyphenethyl)-4-((diethylamino)methyl)-N-(...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216202(N-(2-chlorophenethyl)-4-(piperidin-1-ylmethyl)-N-(...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216200(N-(2-chlorophenethyl)-N-(1-formylpyrrolidin-3-yl)-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216198(N-(2-chlorophenethyl)-4-isopropoxy-N-(tetrahydroth...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216195(N-(2-chlorophenethyl)-4-isopropoxy-N-(piperidin-3-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216192(N-(2-chlorophenethyl)-N-(azetidin-3-yl)-4-isopropo...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50216185(N-(2-chlorophenethyl)-4-isopropoxy-N-(1-methylpyrr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50378789(CHEMBL1170117)
Affinity DataKi:  1.18E+4nMAssay Description:Inhibition of human recombinant soluble Kexin isozyme 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50378790(CHEMBL1171759)
Affinity DataKi:  7.50E+4nMAssay Description:Inhibition of human recombinant soluble Kexin isozyme 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50378788(CHEMBL1170116)
Affinity DataKi:  1.25E+5nMAssay Description:Inhibition of human recombinant soluble Kexin isozyme 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50378793(CHEMBL1170298)
Affinity DataKi:  1.40E+5nMAssay Description:Inhibition of human recombinant soluble Kexin isozyme 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50378791(CHEMBL1170119)
Affinity DataKi:  2.25E+5nMAssay Description:Inhibition of human recombinant soluble Kexin isozyme 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50378792(CHEMBL1170606)
Affinity DataKi:  2.65E+5nMAssay Description:Inhibition of human recombinant soluble Kexin isozyme 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed