Compile Data Set for Download or QSAR
Report error Found 1422 Enz. Inhib. hit(s) with Target = 'Melatonin receptor type 1B'
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50316691(N-[2-(7-{4-[8-(2-(2-Furoyl)aminoethyl)naphthalen-2...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50316692(N-[2-(7-{4-(4'-Hydroxymethylbiphenyl-4-yloxy}butox...)
Affinity DataEC50:  26nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50316700(N-[2-(7-{4-[8-(2-Cyclopropanecarbonylaminoethyl)na...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50114703(N-[2-(5-Methoxy-2-phenyl-benzofuran-3-yl)-ethyl]-a...)
Affinity DataEC50:  0.0960nMAssay Description:Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50114704(N-{2-[5-Methoxy-2-(3-methoxy-benzyl)-benzofuran-3-...)
Affinity DataEC50:  0.720nMAssay Description:Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50114710(N-[2-(2-Cyclohexylmethyl-5-methoxy-benzofuran-3-yl...)
Affinity DataEC50:  10nMAssay Description:Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50114705(N-[2-(2-Benzyl-benzofuran-3-yl)-ethyl]-acetamide |...)
Affinity DataEC50: >1.00E+4nMAssay Description:Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50114723(N-{2-[5-Ethyl-2-(3-methoxy-benzyl)-benzofuran-3-yl...)
Affinity DataEC50:  19nMAssay Description:Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50114715(N-{2-[5-Methoxy-2-(4-methoxy-benzyl)-benzofuran-3-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50114702(N-{2-[5-Methoxy-2-(2-methoxy-benzyl)-benzofuran-3-...)
Affinity DataEC50:  0.410nMAssay Description:Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50114701(But-3-enoic acid {2-[5-methoxy-2-(3-methoxy-benzyl...)
Affinity DataEC50:  0.390nMAssay Description:Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.470nMAssay Description:Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50114707(But-3-enoic acid [2-(2-benzyl-5-methoxy-benzofuran...)
Affinity DataEC50:  0.170nMAssay Description:Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50114716(N-[2-(2-Benzyl-5-methoxy-benzofuran-3-yl)-ethyl]-a...)
Affinity DataEC50: >1.00E+4nMAssay Description:Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50114700(N-{2-[5-Methoxy-2-(3-trifluoromethyl-benzyl)-benzo...)
Affinity DataEC50:  1.26nMAssay Description:Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50125644(4-((R)-6-Methoxy-indan-1-yl)-piperazine-1-carboxyl...)
Affinity DataEC50:  2.40nMAssay Description:Effective concentration against human MT2 (Melatonin) receptor stably expressed in NIH3T3 cells in adenylyl cyclase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50035179(S 20098 | N-[2-(7-Methoxy-naphthalen-1-yl)-ethyl]-...)
Affinity DataEC50:  0.100nMAssay Description:Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.490nMAssay Description:Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50149169(Cyclopropanecarboxylic acid [3-(2-methyl-benzooxaz...)
Affinity DataEC50:  0.740nMAssay Description:Agonist activity for its ability to inhibit forskolin-stimulated cAMP accumulation against MT receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50153420(1N-[2-[2-(4-phenylbutyl)benzo[b]furan-4-yl]-(1R,2R...)
Affinity DataEC50:  21nMAssay Description:Agonist activity towards human Melatonin receptor type 1B was determined by its ability to inhibit forskolin stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50096967(CHEMBL3580916)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50096968(CHEMBL3580919)
Affinity DataEC50:  5.5nMAssay Description:Agonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50096973(CHEMBL3580907)
Affinity DataEC50:  81nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50096976(CHEMBL3580908)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50096977(CHEMBL3580909)
Affinity DataEC50:  132nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50097043(CHEMBL3580910)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50097050(CHEMBL3580912)
Affinity DataEC50:  503nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50097064(CHEMBL3580913)
Affinity DataEC50:  295nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50097066(CHEMBL3580915)
Affinity DataEC50:  71nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50096967(CHEMBL3580916)
Affinity DataEC50:  881nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50097067(CHEMBL3580917)
Affinity DataEC50:  457nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50097068(CHEMBL3580918)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50096968(CHEMBL3580919)
Affinity DataEC50:  29nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50097115(CHEMBL3580920)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50097116(CHEMBL3580921)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50097117(CHEMBL3580922)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50096969(CHEMBL3580924)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50096971(CHEMBL3580926)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM30707(3-(2-DIMETHYLAMINOETHYL)-5-METHOXYINDOLE | CHEMBL7...)
Affinity DataEC50:  112nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.0690nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.490nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50263659(N-[2-(3-(3-hydroxymethylphenyl)-7-methoxynaphth-1-...)
Affinity DataEC50:  0.760nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50263602(N-[2-(3-phenyl-7-methoxynaphth-1-yl)ethyl] acetami...)
Affinity DataEC50:  2.40nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50035179(S 20098 | N-[2-(7-Methoxy-naphthalen-1-yl)-ethyl]-...)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50263713(N-[2-(3-(3-Formylphenyl)-7-methoxynaphth-1-yl)ethy...)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50263661(N-[2-(3-(3-Hydroxymethylphenyl)-7-methoxynaphth-1-...)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50263662(N-[2-(3-(3-Hydroxymethylphenyl)-7-methoxynaphth-1-...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50263716(N-[2-(3-(3-Bromomethylphenyl)-7-methoxynaphth-1-yl...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50263758(N-[2-(3-(3-Aminophenyl)-7-methoxynaphth-1-yl)ethyl...)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50263551(N-[2-(3-(3-Methylaminophenyl)-7-methoxynaphth-1-yl...)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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