Compile Data Set for Download or QSAR
Report error Found 2505 Enz. Inhib. hit(s) with Target = 'Melanocortin receptor 5'
TargetMelanocortin receptor 5(Mouse)
University of Florida

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  170nMAssay Description:Compound was evaluated for its agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50184359(MT-II | CHEMBL430239 | Ac-Nle-c[Asp-His-DPhe-Arg-T...)
Affinity DataEC50:  25nMAssay Description:Agonistic activity against human melanocortin receptor (hMC5R) for cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50454555(CHEMBL2115441)
Affinity DataEC50:  6nMAssay Description:Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.580nMAssay Description:Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50058158((3S,6S,9S,12S,15S,18S,26S)-18-((S)-2-Acetylamino-h...)
Affinity DataEC50:  269nMAssay Description:Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50184359(MT-II | CHEMBL430239 | Ac-Nle-c[Asp-His-DPhe-Arg-T...)
Affinity DataEC50:  1.5nMAssay Description:Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.580nMAssay Description:effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50121260(CID44366183 | 3-(2-Acetylamino-hexanoylamino)-17-[...)
Affinity DataEC50:  2.10nMAssay Description:Activity of cyclic alpha MSH analogues at human melanocortin receptor Melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50121259(6-(3-Guanidino-propyl)-3-(1H-indol-3-ylmethyl)-9-n...)
Affinity DataEC50:  530nMAssay Description:Binding affinity against human Melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50001477(CHEMBL2372588)
Affinity DataEC50: >100nMAssay Description:Binding affinity against human Melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50121267(CID44366214 | 5-(2-Acetylamino-hexanoylamino)-19-[...)
Affinity DataEC50:  0.0700nMAssay Description:Binding affinity against human Melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50121257(CID44366186 | 6-(2-Acetylamino-hexanoylamino)-20-[...)
Affinity DataEC50:  390nMAssay Description:Binding affinity against human Melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50001518(CHEMBL2112603)
Affinity DataEC50:  880nMAssay Description:Effective concentration of peptide at 50% maximal cAMP generation (10e-10 to 10e-4 M)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50001519(CHEMBL2111808)
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration of peptide at 50% maximal cAMP generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50001520(CHEMBL2111807)
Affinity DataEC50:  190nMAssay Description:Effective concentration of peptide at 50% maximal cAMP generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  1nMAssay Description:Effective concentration of peptide at 50% maximal cAMP generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataEC50:  8.10nMAssay Description:Effective concentration of peptide at 50% maximal cAMP generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50131880(Ac-c[Cys-Glu-His-D-Nal(2')-Arg-Trp-Cys]-Pro-Pro-Ly...)
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration of peptide at 50% maximal cAMP generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50001505(CHEMBL2112604)
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration of peptide at 50% maximal cAMP generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50131875(Ac-c[Pen-Glu-His-D-Phe-Arg-Trp-Cys]-Pro-Pro-Lys-As...)
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration of peptide at 50% maximal cAMP generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50131872(Ac-c[Asp-Glu-His-D-Phe-Arg-Trp-Lys]-Pro-Pro-Lys-As...)
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration of peptide at 50% maximal cAMP generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50131877(Ac-c[Cys-Glu-Pro-D-Nal(2')-Arg-Trp-Cys]-Pro-Pro-Ly...)
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration of peptide at 50% maximal cAMP generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Mouse)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50017128(CHEMBL3287322)
Affinity DataEC50:  0.840nMAssay Description:Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Mouse)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50017130(CHEMBL3287323)
Affinity DataEC50:  0.450nMAssay Description:Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Mouse)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50017131(CHEMBL3287324)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Mouse)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50017132(CHEMBL3287325)
Affinity DataEC50:  3nMAssay Description:Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Mouse)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50017133(CHEMBL3287326)
Affinity DataEC50:  0.630nMAssay Description:Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Mouse)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50017134(CHEMBL3287327)
Affinity DataEC50:  2.40nMAssay Description:Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Mouse)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50017135(CHEMBL3287328)
Affinity DataEC50:  1nMAssay Description:Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Mouse)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50017136(CHEMBL3287329)
Affinity DataEC50:  5.10nMAssay Description:Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Mouse)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50017181(CHEMBL441738)
Affinity DataEC50:  0.260nMAssay Description:Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50134950(H-Tyr-Val-Nle-Gly-His-D-Nal(2')-Arg-D-Nal(2')-Asp-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50134955(H-Tyr-Val-Nle-Gly-Pro-D-Nal(2')-Arg-Trp-Asp-Arg-Ph...)
Affinity DataEC50: >1.00E+4nMAssay Description:Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50134957(H-Tyr-Val-Nle-Gly-MePhe-Phe-Arg-D-Nal(2)-Asp-Arg-P...)
Affinity DataEC50:  210nMAssay Description:Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50134943(H-Tyr-Val-Nle-Gly-Aib-Phe-Arg-D-Nal(2')-Asp-Arg-Ph...)
Affinity DataEC50:  1.80nMAssay Description:Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50134949(H-Tyr-Val-Nle-c[Cys-His-Phe-Arg-Trp-D-Cys]-Arg-Phe...)
Affinity DataEC50:  270nMAssay Description:Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50134951(H-Tyr-Val-Nle-c[Asp-His-Phe-Arg-Trp-Lys]-Arg-Phe-G...)
Affinity DataEC50:  200nMAssay Description:Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50134942(H-Tyr-Val-c[Cys-Gly-His-Phe-Arg-Trp-D-Cys]-Arg-Phe...)
Affinity DataEC50: >1.00E+4nMAssay Description:Intracellular cAMP accumulation in human Melanocortin 5 receptor functional assay.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50: >3.00E+3nMAssay Description:Functional activity as concentration at 50% maximum cAMP accumulation in rat Melanocortin-5 receptor (rMC5R)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  736nMAssay Description:Evaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  737nMAssay Description:Functional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC5R) receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50105891(13-Ethyl-6-(3-guanidino-propyl)-3-(1H-indol-3-ylme...)
Affinity DataEC50:  220nMAssay Description:Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50105882(Cyclo Ac-Cys-Glu-His-D-Phe-(3,4-di-Cl)-Arg-Trp-Gly...)
Affinity DataEC50:  73nMAssay Description:Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50105884(9-(3-Guanidino-propyl)-6-(1H-indol-3-ylmethyl)-12-...)
Affinity DataEC50: >5.00E+3nMAssay Description:Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50105890(12-Amino-6-(3-guanidino-propyl)-3-(1H-indol-3-ylme...)
Affinity DataEC50:  200nMAssay Description:Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50105892(12-(2-Acetylamino-hexanoylamino)-6-(3-guanidino-pr...)
Affinity DataEC50:  87nMAssay Description:Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50105888(6-(3-Guanidino-propyl)-3-(1H-indol-3-ylmethyl)-9-n...)
Affinity DataEC50:  530nMAssay Description:Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50105893(9-(3-Guanidino-propyl)-15-(3H-imidazol-4-ylmethyl)...)
Affinity DataEC50:  210nMAssay Description:Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50105876(15-Amino-6-(3-guanidino-propyl)-12-(3H-imidazol-4-...)
Affinity DataEC50:  18nMAssay Description:Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50105880(15-Acetylamino-6-(3-guanidino-propyl)-12-(3H-imida...)
Affinity DataEC50:  4.20nMAssay Description:Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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