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Report error Found 927 Enz. Inhib. hit(s) with Target = 'Matrilysin'
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50642814(CHEMBL5574207)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50642820(CHEMBL5590289)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50642822(CHEMBL5575564)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50642821(CHEMBL5590711)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50642825(CHEMBL5575333)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50642824(CHEMBL5573957)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50642827(CHEMBL5584155)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50642819(CHEMBL5572317)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50642826(CHEMBL5572421)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50287379(RS-39066 | 4-[(S)-2-((R)-2-Hydroxycarbamoylmethyl-...)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of matrilysin, matrix metalloprotease-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50642828(CHEMBL5573293)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50642818(CHEMBL5569043)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50642823(CHEMBL5570298)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50072583((2R,3S)-2,N*1*-Dihydroxy-N*4*-[(S)-1-(1H-indole-3-...)
Affinity DataIC50: 0.300nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloprotease 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50642813(CHEMBL5575734)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50642816(CHEMBL5570760)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50072563((2R,3S)-2-Allyl-N*1*-hydroxy-N*4*-[(S)-1-(1H-indol...)
Affinity DataIC50: 0.780nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloprotease 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50102594(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of matrix metalloprotease-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50642817(CHEMBL5567332)
Affinity DataIC50: 0.960nMAssay Description:Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50287383((R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-3-methyl-1-(...)
Affinity DataIC50: 1nMAssay Description:Inhibition of matrilysin, matrix metalloprotease-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50287376(2-[(S)-1-((R)-2-Hydroxycarbamoylmethyl-4-methyl-pe...)
Affinity DataIC50: 1nMAssay Description:Inhibition of matrilysin, matrix metalloprotease-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50072564((2R,3S)-N*4*-[(S)-1-Benzyl-2-(1H-indol-3-yl)-2-oxo...)
Affinity DataIC50: 1.10nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloprotease 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50072582((2R,3S)-2-Allyl-N*4*-[(S)-1-benzyl-2-oxo-2-(1H-pyr...)
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloprotease 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50102608(11-Isobutyl-2,10-dioxo-1-oxa-3,9-diaza-cyclopentad...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of matrix metalloprotease-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50072572((7S,8R,11S)-11-(4-Hydroxymethyl-benzoyl)-8-isobuty...)
Affinity DataIC50: 1.5nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloprotease 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50071263((7S,8R,11S)-8-Isobutyl-9-oxo-2-oxa-10-aza-bicyclo[...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of fibroblast matrilysin (MMP-7)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50071263((7S,8R,11S)-8-Isobutyl-9-oxo-2-oxa-10-aza-bicyclo[...)
Affinity DataIC50: 1.60nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloprotease 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50071268((7S,8R,11S)-8-Isobutyl-9-oxo-2-oxa-10-aza-bicyclo[...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of fibroblast matrilysin (MMP-7)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50642812(CHEMBL5590933)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50630425(CHEMBL5416269)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant human MMP7 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50630424(CHEMBL5432095)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of recombinant human MMP7 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50287378((R)-N*1*-[(S)-1-(1H-Benzoimidazol-2-yl)-3-methyl-b...)
Affinity DataIC50: 2nMAssay Description:Inhibition of matrilysin, matrix metalloprotease-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50072566((2R,3S)-2-Allyl-N*4*-[(S)-1-benzyl-2-(1H-indol-3-y...)
Affinity DataIC50: 2.20nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloprotease 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50072566((2R,3S)-2-Allyl-N*4*-[(S)-1-benzyl-2-(1H-indol-3-y...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human MMP7 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50072579((8S,9R,12S)-12-Benzoyl-9-isobutyl-10-oxo-2-oxa-11-...)
Affinity DataIC50: 2.20nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloprotease 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50: 2.40nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloprotease 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50071269((7S,8R,11S)-8-Isobutyl-9-oxo-2-oxa-10-aza-bicyclo[...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of fibroblast matrilysin (MMP-7)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50071262((8S,9R,12S)-9-Isobutyl-10-oxo-2-oxa-11-aza-bicyclo...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of fibroblast matrilysin (MMP-7)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50630413(CHEMBL5417105)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant human MMP7 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50071265((7S,8R,11S)-9-Oxo-8-(3-p-tolyl-propyl)-2-oxa-10-az...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of fibroblast matrilysin (MMP-7)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50630427(CHEMBL5403802)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant human MMP7 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50630413(CHEMBL5417105)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant human MMP7 assessed as enzyme activity by measuring fluorescence using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50086884(N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO...)
Affinity DataKi:  3nMAssay Description:Inhibition of Matrix metalloprotease-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50064341(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataIC50: 3nMAssay Description:Inhibition of fibroblast matrilysin (MMP-7)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50287381((S)-2-Cyclohexyl-N*4*-hydroxy-N*1*-[(S)-3-methyl-1...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of matrilysin, matrix metalloprotease-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50072568((8S,9R,12S)-12-(1H-Indole-3-carbonyl)-9-isobutyl-1...)
Affinity DataIC50: 3.10nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloprotease 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50072567((7S,8R,11S)-11-Benzoyl-8-isobutyl-9-oxo-2-oxa-10-a...)
Affinity DataIC50: 3.30nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloprotease 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50072578((2R,3S)-2-Allyl-N*4*-((S)-1-benzyl-2-oxo-2-phenyl-...)
Affinity DataIC50: 3.60nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloprotease 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50630429(CHEMBL5426536)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of recombinant human MMP7 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM28485((2S)-2-({4-[4-(1-benzofuran-2-amido)phenyl]benzene...)
Affinity DataEC50:  4nMAssay Description:Inhibitory concentration against MMP-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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