BindingDB PrimarySearch_ki

Report error Found 906 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 3'

Mitogen-activated protein kinase 3(Human)
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)

Kd: 8.40E+6nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair

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Mitogen-activated protein kinase 3(Human)
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM103302(SCH772984 | US8546404, 6)

Kd: 213nMpH: 7.5 T: 2°CAssay Description:For ERK1 and ERK2, the buffer contained 20 mM HEPES (pH 7.5), 150 mM NaCl and 0.5 mM TCEP. For haspin, the buffer contained 20 mM HEPES (pH 7.5), 250...More data for this Ligand-Target Pair

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PubMed

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154585(US8999957, Column 141, Compound 1 | US8999957, Tab...)

Kd: 106nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154586(US8999957, Column 141, Compound 2)

Kd: 73nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154587(US8999957, Column 141, Compound 3)

Kd: 290nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154588(US8999957, Column 141, Compound 4 | US8999957, Tab...)

Kd: 0.580nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154589(US8999957, Column 141, Compound 5 | US8999957, Tab...)

Kd: 1.20nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154590(US8999957, Column 141, Compound 6 | US8999957, Tab...)

Kd: 2nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154591(US8999957, Column 141, Compound 7 | US8999957, Tab...)

Kd: 0.610nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154595(US8999957, Column 148, Compound 1)

Kd: 8nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154596(US8999957, Column 152, Compound 1)

Kd: 0.800nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154597(US8999957, Column 152, Compound 2 | US8999957, Tab...)

Kd: 118nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154598(US8999957, Column 153, Compound 3 | US8999957, Tab...)

Kd: 38nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154599(US8999957, Column 153, Compound 4 | US8999957, Tab...)

Kd: 0.300nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154600(US8999957, Column 153, Compound 5 | US8999957, Tab...)

Kd: 0.600nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154601(US8999957, Column 155, Compound 1 | US8999957, Tab...)

Kd: 1.40nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154602(US8999957, Column 162-163, Compound 1 | US8999957,...)

Kd: 9.20nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154604(US8999957, Column 162-163, Compound 3)

Kd: 82nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154605(US8999957, Column 162-163, Compound 4 | US8999957,...)

Kd: 76nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154607(US8999957, Column 162-163, Compound 6)

Kd: 10.5nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154608(US8999957, Column 162-163, Compound 7)

Kd: 1.00E+3nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154585(US8999957, Column 141, Compound 1 | US8999957, Tab...)

Kd: 106nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154634(US8999957, Table 1, Compound 2)

Kd: 0.300nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154635(US8999957, Table 1, Compound 3)

Kd: 0.600nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154597(US8999957, Column 152, Compound 2 | US8999957, Tab...)

Kd: 118nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154598(US8999957, Column 153, Compound 3 | US8999957, Tab...)

Kd: 38nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154599(US8999957, Column 153, Compound 4 | US8999957, Tab...)

Kd: 0.300nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154600(US8999957, Column 153, Compound 5 | US8999957, Tab...)

Kd: 0.600nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154640(US8999957, Table 1, Compound 8)

Kd: 2.90nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154641(US8999957, Table 1, Compound 9)

Kd: 1.40nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154642(US8999957, Table 1, Compound 10)

Kd: 2.60nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154643(US8999957, Table 1, Compound 11)

Kd: 804nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154588(US8999957, Column 141, Compound 4 | US8999957, Tab...)

Kd: 0.580nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154589(US8999957, Column 141, Compound 5 | US8999957, Tab...)

Kd: 1.20nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154590(US8999957, Column 141, Compound 6 | US8999957, Tab...)

Kd: 2nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154591(US8999957, Column 141, Compound 7 | US8999957, Tab...)

Kd: 0.610nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154602(US8999957, Column 162-163, Compound 1 | US8999957,...)

Kd: 9.20nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154605(US8999957, Column 162-163, Compound 4 | US8999957,...)

Kd: 76nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154601(US8999957, Column 155, Compound 1 | US8999957, Tab...)

Kd: 1.40nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154664(US8999957, Table 2, Compound 1)

Kd: 0.810nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154665(US8999957, Table 2, Compound 2)

Kd: 0.400nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154666(US8999957, Table 2, Compound 3)

Kd: 0.400nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154667(US8999957, Table 2, Compound 4)

Kd: 0.5nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154668(US8999957, Table 2, Compound 5)

Kd: 6.60nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154669(US8999957, Table 2, Compound 6)

Kd: 0.520nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154670(US8999957, Table 2, Compound 7)

Kd: 0.0520nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154671(US8999957, Table 2, Compound 8)

Kd: 11nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154672(US8999957, Table 2, Compound 9)

Kd: 2.36nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154673(US8999957, Table 2, Compound 10)

Kd: 0.220nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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US Patent

Mitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent

PNG

BDBM154674(US8999957, Table 2, Compound 11)

Kd: 0.510nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair

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Displayed 1 to 50 (of 906 total ) | Next | Last >>

Filter my 906 hits

Targets 1▿
- Mitogen-activated protein kinase 3 906
Publications 50▿
- US Patent US9796700 (2017) 349
- US Patent US8999957 (2015) 102
- Nat Biotechnol 29: 1046-51 (2011) 72
- J Med Chem 59: 5650-60 (2016) 42
- Nat Biotechnol 26: 127-32 (2008) 38
- US Patent US10493060 (2019) 33
- US Patent US10525036 (2020) 32
- Eur J Med Chem 127: 997-1011 (2017) 30
- Bioorg Med Chem Lett 26: 2600-4 (2016) 23
- Eur J Med Chem 94: 397-404 (2015) 21
- ACS Med Chem Lett 9: 761-767 (2018) 17
- Bioorg Med Chem 16: 4715-32 (2008) 7
- Blood 114: 2984-92 (2009) 7
- J Med Chem 65: 13561-13573 (2022) 7
- Proc Natl Acad Sci U S A 104: 20523-8 (2007) 6
- Eur J Med Chem 250: (2023) 5
- Eur J Med Chem 164: 334-341 (2019) 5
- Eur J Med Chem 220: (2021) 5
- J Med Chem 45: 2366-78 (2002) 5
- Bioorg Med Chem 17: 4302-12 (2009) 4
- Bioorg Med Chem Lett 15: 1973-7 (2005) 4
- Eur J Med Chem 68: 361-71 (2013) 4
- J Med Chem 53: 6368-77 (2010) 3
- Bioorg Med Chem Lett 21: 1167-70 (2011) 3
- Bioorg Med Chem Lett 16: 4163-8 (2006) 2
- Bioorg Med Chem Lett 25: 4047-56 (2015) 2
- US Patent US11440904 (2022) 2
- Bioorg Med Chem Lett 21: 7155-65 (2011) 2
- Science 281: 533-538 (1998) 2
- J Med Chem 55: 1868-97 (2012) 2
- Bioorg Med Chem Lett 28: 2622-2626 (2018) 2
- J Biol Chem 281: 9987-95 (2006) 2
- J Med Chem 62: 7697-7707 (2019) 2
- Nat Chem Biol 10: 853-860 (2014) 2
- US Patent US10844038 (2020) 1
- J Med Chem 65: 12650-12674 (2022) 1
- J Med Chem 51: 1637-48 (2008) 1
- Eur J Med Chem 161: 456-467 (2019) 1
- Bioorg Med Chem Lett 22: 4613-8 (2012) 1
- Eur J Med Chem 167: 61-75 (2019) 1
- Bioorg Med Chem 24: 2466-75 (2016) 1
- Bioorg Med Chem Lett 16: 5122-6 (2006) 1
- J Med Chem 54: 8030-50 (2011) 1
- Eur J Med Chem 45: 3389-93 (2010) 1
- J Med Chem 52: 1853-63 (2009) 1
- Bioorg Med Chem 24: 521-44 (2016) 1
- US Patent US20240309018 (2024) 1
- PubChem Bioassay (2008) 1
- Bioorg Med Chem 26: 1740-1750 (2018) 1
- Bioorg Med Chem Lett 21: 3856-60 (2011) 1
- ...
Institutions 41▿
- Celgene Car 349
- Ambit Biosciences 118
- Merck Sharp & Dohme 102
- Recurium Ip Holdings 65
- Array Biopharma 42
- Sichuan University 30
- Green Valley Research Institute 23
- Cairo University 21
- Merck 17
- Takeda Pharmaceutical 9
- Zhejiang University 8
- Southwest Jiaotong University 7
- Amgen 6
- University of Oxford 6
- Aventis Pharma Deutschland 5
- Peking University 5
- China Pharmaceutical University 5
- National Institute of Pharmaceutical Education and Research (NIPER) 5
- Bayer Research Center 4
- National University of Ireland 3
- Vertex Pharmaceuticals 2
- George Washington University 2
- Milstein Zhang & Wu 2
- Chiron 2
- Chengdu University 2
- University of Queensland 2
- University of California 2
- Ontario Institute For Cancer Research 2
- Ansaris 2
- Icahn School of Medicine At Mount Sinai 1
- University of Florida 1
- Beijing Normal University 1
- Institut Curie 1
- Cellzome 1
- Pfizer 1
- Sabila Biosciences 1
- East China Normal University 1
- University of Naples Federico Ii 1
- University of Illinois At Chicago 1
- Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories 1
- D3 Bio (Wuxi) Co. 1
- ...
Affinity: 0.010 to 1.0E+8 nM▿
- Ki 9
- IC50 669
- Kd 227
- EC50 1
- Affinity ≤ nM
Xtal structures: 3
Docked structures: 0
Catalog Cmpds: 121