Compile Data Set for Download or QSAR
Report error Found 1956 Enz. Inhib. hit(s) with Target = 'Lysine-specific demethylase 4C'
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50457156(CHEMBL4207071)
Affinity DataEC50:  32nMAssay Description:Inhibition of full-length KDM4C (unknown origin) expressed in human KYSE-150 cells assessed as increase in H3K36me3 level after 24 hrs by Western blo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM293660(3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of full-length KDM4C (unknown origin) expressed in human KYSE-150 cells assessed as increase in H3K36me3 level after 24 hrs by Western blo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM321348(US10179769, Example 62 | 3-({[(1R)-6-methoxy-1,2,3...)
Affinity DataEC50:  560nMAssay Description:Inhibition of full-length KDM4C (unknown origin) expressed in human KYSE-150 cells assessed as increase in H3K36me3 level after 24 hrs by Western blo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50457157(CHEMBL4216399)
Affinity DataEC50:  19nMAssay Description:Inhibition of full-length KDM4C (unknown origin) expressed in human KYSE-150 cells assessed as increase in H3K36me3 level after 24 hrs by Western blo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50457513(CHEMBL4212908)
Affinity DataKd:  1.29E+5nMAssay Description:Binding affinity to 6His-tagged and human KDM4C tandem TUDOR domain (874 to 990 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM293660(3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of KDM4C in human KYSE-150 cells overexpressing KDM4C assessed as increase in H3K36me3 measured by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50454844(CHEMBL4204694)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of KDM4C (unknown origin) expressed in Escherichia coli using biotinylated peptide as substrate pretreated for 15 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50598661(CHEMBL5203487)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of KDM4C (unknown origin) measured by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM263974(2-(5-(benzyloxy)-1H-pyrazol-1- yl)isonicotinic aci...)
Affinity DataIC50: 5nMAssay Description:Inhibition of KDM4C (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM321348(US10179769, Example 62 | 3-({[(1R)-6-methoxy-1,2,3...)
Affinity DataIC50: 6nMAssay Description:Inhibition of KDM4C (unknown origin) using biotinylated H3K9me3 peptide and alpha-ketoglutarate as substrate pretreated for 1 hr followed by substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM321334(US10179769, Example 48 | 3-{[(1R)-1,2,3,4-tetrahyd...)
Affinity DataIC50: 8nMAssay Description:Inhibition of KDM4C (unknown origin) using biotinylated H3K9me3 peptide and alpha-ketoglutarate as substrate pretreated for 1 hr followed by substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM188286(US9073941, 605)
Affinity DataIC50: 8nMAssay Description:Inhibition of KDM4C (unknown origin) using methylated H3 peptide as substrate by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM293660(3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Affinity DataIC50: 9nMAssay Description:Inhibition of KDM4C (unknown origin) using biotinylated H3K9me3 peptide and alpha-ketoglutarate as substrate pretreated for 1 hr followed by substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50538952(CHEMBL4648732)
Affinity DataIC50: 11nMAssay Description:Inhibition of KDM4C (unknown origin) using methylated H3 peptide as substrate by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50454854(CHEMBL4209038)
Affinity DataIC50: 12nMAssay Description:Inhibition of KDM4C (unknown origin) expressed in Escherichia coli using biotinylated peptide as substrate pretreated for 15 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM314142(US10179769, Example 46 | 3-[(1,2,3,4-tetrahydronap...)
Affinity DataIC50: 12nMAssay Description:Inhibition of KDM4C (unknown origin) using biotinylated H3K9me3 peptide and alpha-ketoglutarate as substrate pretreated for 1 hr followed by substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM264020(2-[5-[(4- cyanophenyl)methoxy]pyrazol-1- yl]pyridi...)
Affinity DataIC50: 14nMAssay Description:Inhibition of KDM4C (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50538954(CHEMBL4646339)
Affinity DataIC50: 16nMAssay Description:Inhibition of KDM4C (unknown origin) using methylated H3 peptide as substrate by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50457156(CHEMBL4207071)
Affinity DataIC50: 17nMAssay Description:Inhibition of KDM4C (unknown origin) using biotinylated H3K9me3 peptide and alpha-ketoglutarate as substrate pretreated for 1 hr followed by substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM264025(2-(4-[2-(dimethylamino)ethyl]- 5-[(4- fluorophenyl...)
Affinity DataIC50: 19nMAssay Description:Inhibition of KDM4C (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50538953(CHEMBL1316847)
Affinity DataIC50: 19nMAssay Description:Inhibition of KDM4C (unknown origin) using methylated H3 peptide as substrate by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM26113(pyridine-2,4-dicarboxylic acid | cid_10365 | pyrid...)
Affinity DataIC50: 19nMAssay Description:Inhibition of KDM4C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50454853(CHEMBL4205183)
Affinity DataIC50: 22nMAssay Description:Inhibition of KDM4C (unknown origin) expressed in Escherichia coli using biotinylated peptide as substrate pretreated for 15 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50454849(CHEMBL4218675)
Affinity DataIC50: 23nMAssay Description:Inhibition of KDM4C (unknown origin) expressed in Escherichia coli using biotinylated peptide as substrate pretreated for 15 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50454859(CHEMBL4206181)
Affinity DataIC50: 23nMAssay Description:Inhibition of KDM4C (unknown origin) expressed in Escherichia coli using biotinylated peptide as substrate pretreated for 15 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM263975(2-{5-[(4-fluorobenzyl)oxy]-1H- pyrazol-1-yl}pyridi...)
Affinity DataIC50: 24nMAssay Description:Inhibition of KDM4C (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50454855(CHEMBL4215000)
Affinity DataIC50: 27nMAssay Description:Inhibition of KDM4C (unknown origin) expressed in Escherichia coli using biotinylated peptide as substrate pretreated for 15 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50438921(CHEMBL1394266)
Affinity DataIC50: 29nMAssay Description:Inhibition of KDM4C (unknown origin) using methylated H3 peptide as substrate by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50598660(CHEMBL5203308)
Affinity DataIC50: 33nMAssay Description:Inhibition of KDM4C (unknown origin) measured by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM191600(US9714230, 89 | 2-(5-((4-chloro-2-methylbenzyl)oxy...)
Affinity DataIC50: 35nMAssay Description:Inhibition of KDM4C (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM293660(3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Affinity DataIC50: 35nMAssay Description:Inhibition of KDM4C (unknown origin) using biotinylated H3K9me3 peptide and alpha-ketoglutarate as substrate pretreated for 1 hr followed by substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM293660(3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Affinity DataIC50: 35nMAssay Description:Inhibition of KDM4C (unknown origin) using H3K9me3 as substrate and measured by LANCE TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM264012(2-[5-[(4-chloro-2- methoxyphenyl)methoxy]pyrazol- ...)
Affinity DataIC50: 38nMAssay Description:Inhibition of KDM4C (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50454848(CHEMBL4205285)
Affinity DataIC50: 38nMAssay Description:Inhibition of KDM4C (unknown origin) expressed in Escherichia coli using biotinylated peptide as substrate pretreated for 15 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM264012(2-[5-[(4-chloro-2- methoxyphenyl)methoxy]pyrazol- ...)
Affinity DataIC50: 38nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM191600(US9714230, 89 | 2-(5-((4-chloro-2-methylbenzyl)oxy...)
Affinity DataIC50: 41nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50538950(CHEMBL4640696)
Affinity DataIC50: 42nMAssay Description:Inhibition of KDM4C (unknown origin) using methylated H3 peptide as substrate by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50454847(CHEMBL4203936)
Affinity DataIC50: 46nMAssay Description:Inhibition of KDM4C (unknown origin) expressed in Escherichia coli using biotinylated peptide as substrate pretreated for 15 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50457157(CHEMBL4216399)
Affinity DataIC50: 48nMAssay Description:Inhibition of KDM4C (unknown origin) using biotinylated H3K9me3 peptide and alpha-ketoglutarate as substrate pretreated for 1 hr followed by substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50454858(CHEMBL4218774)
Affinity DataIC50: 53nMAssay Description:Inhibition of KDM4C (unknown origin) expressed in Escherichia coli using biotinylated peptide as substrate pretreated for 15 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50158703(US9714230, 53 | CHEMBL3785832 | US9604961, Example...)
Affinity DataIC50: 54nMAssay Description:Inhibition of KDM4C (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM670388(US20240139197, Compound 21)
Affinity DataIC50: 54nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50454846(CHEMBL4211201)
Affinity DataIC50: 55nMAssay Description:Inhibition of KDM4C (unknown origin) expressed in Escherichia coli using biotinylated peptide as substrate pretreated for 15 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50153331(CHEMBL3774552)
Affinity DataIC50: 63nMAssay Description:Inhibition of KDM4C (unknown origin) using H3K9Me3 peptide as substrate assessed as demethylation of substrate by Rapidfire mass spectrometric analys...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50153330(CHEMBL3774859)
Affinity DataIC50: 63nMAssay Description:Inhibition of KDM4C (unknown origin) using H3K9Me3 peptide as substrate assessed as demethylation of substrate by Rapidfire mass spectrometric analys...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50151392(CHEMBL3775262)
Affinity DataIC50: 64nMAssay Description:Inhibition of N-terminal His6-tagged KDM4C (1 to 352 residues) (unknown origin) expressed in Escherichia coli Rosetta 2(DE3)pLysS using biotinylated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50151392(CHEMBL3775262)
Affinity DataIC50: 64nMAssay Description:Inhibition of KDM4C (1 to 352 residues) (unknown origin) using biotin-tagged histone H3 (residues 1-21) lysine 9 trimethylated peptide as substrate i...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50151393(CHEMBL3775867)
Affinity DataIC50: 65nMAssay Description:Inhibition of N-terminal His6-tagged KDM4C (1 to 352 residues) (unknown origin) expressed in Escherichia coli Rosetta 2(DE3)pLysS using biotinylated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM50454856(CHEMBL4208277)
Affinity DataIC50: 65nMAssay Description:Inhibition of KDM4C (unknown origin) expressed in Escherichia coli using biotinylated peptide as substrate pretreated for 15 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM263978(2-{5-[(4-methoxybenzyl)oxy]-1H- pyrazol-1-yl}pyrid...)
Affinity DataIC50: 68nMAssay Description:Inhibition of KDM4C (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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