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Report error Found 212 Enz. Inhib. hit(s) with Target = 'Lysine-specific demethylase 2A'
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158851(CHEMBL3786265)
Affinity DataEC50:  1.26E+3nMAssay Description:Inhibition of KDM2A in human MIAPaCa2 cells assessed as increase in H3K36me2 level after 48 hrs by Hoechst 33258 staining based immunofluorescence as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158852(CHEMBL3785340)
Affinity DataEC50:  280nMAssay Description:Inhibition of KDM2A in human MIAPaCa2 cells assessed as increase in H3K36me2 level after 48 hrs by Hoechst 33258 staining based immunofluorescence as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158853(CHEMBL3786188)
Affinity DataEC50:  930nMAssay Description:Inhibition of KDM2A in human MIAPaCa2 cells assessed as increase in H3K36me2 level after 48 hrs by Hoechst 33258 staining based immunofluorescence as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158851(CHEMBL3786265)
Affinity DataEC50:  3.96E+3nMAssay Description:Inhibition of KDM2A in human MIAPaCa2 cells assessed as increase in H3K9me3 level after 48 hrs by Hoechst 33258 staining based immunofluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158852(CHEMBL3785340)
Affinity DataEC50:  660nMAssay Description:Inhibition of KDM2A in human MIAPaCa2 cells assessed as increase in H3K9me3 level after 48 hrs by Hoechst 33258 staining based immunofluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158853(CHEMBL3786188)
Affinity DataEC50:  900nMAssay Description:Inhibition of KDM2A in human MIAPaCa2 cells assessed as increase in H3K9me3 level after 48 hrs by Hoechst 33258 staining based immunofluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50436040(CHEMBL2392184)
Affinity DataKd:  22nMAssay Description:Binding affinity to recombinant 6xHis-tagged JHDM1A (unknown origin) expressed in Escherichia coli BL21 by fluorescence polarization assay in presenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50436040(CHEMBL2392184)
Affinity DataKd:  9.30nMAssay Description:Binding affinity to recombinant 6xHis-tagged JHDM1A (unknown origin) expressed in Escherichia coli BL21 by fluorescence polarization assay in presenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50436040(CHEMBL2392184)
Affinity DataKd:  19nMAssay Description:Binding affinity to recombinant 6xHis-tagged JHDM1A (unknown origin) expressed in Escherichia coli BL21 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50436040(CHEMBL2392184)
Affinity DataKd:  8.20nMAssay Description:Binding affinity to recombinant 6xHis-tagged JHDM1A (unknown origin) expressed in Escherichia coli BL21 by fluorescence polarization assay in presenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50498675(CHEMBL3621881)
Affinity DataIC50: 63nMAssay Description:Inhibition of KDM2A (unknown origin) using Biotin-H3(28-48)K36Me2 and H3(28-48)K36Me2 substrates incubated for 30 mins by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50596053(CHEMBL5173876)
Affinity DataIC50: 63nMAssay Description:Inhibition of human KDM2A preincubated for 15 mins followed by substrate addition and measured after 30 mins using Biotin-H3(28-48)K36Me2 peptide as ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276042(2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-met...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276043(2-[1-(1-phenylethyl)imidazol-4-yl]-4-(1H-triazol-4...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276044(2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276045(2-[1-[2-(2-methoxyphenyl)ethyl]imidazol-4-yl]-4-(1...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276046(2-[1-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)imid...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276047(2-[1-[2-(2-ethoxyphenyl)ethyl]imidazol-4-yl]-4-(1H...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276059(2-[1-[(2,3-dichlorophenyl)methyl]imidazol-4-yl]-4-...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276060(2-[1-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]i...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276061(2-[1-(2-naphthalen-1-ylethyl)imidazol-4-yl]-4-(1H-...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276082(1-benzyl-4-{1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl}...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276083(1-[(2-chlorophenyl)methyl]-4-{1H-[1,2,3]triazolo[4...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276084(1-[(3-chlorophenyl)methyl]-4-{1H-[1,2,3]triazolo[4...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276085(1-[(4-chlorophenyl)methyl]-4-{1H-[1,2,3]triazolo[4...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276086(1-[(3,4-dichlorophenyl)methyl]-4-{1H-[1,2,3]triazo...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276087(1-(4-chlorophenyl)-4-{1H-[1,2,3]triazolo[4,5-c]pyr...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276088(1-(2-chlorophenyl)-4-{1H-[1,2,3]triazolo[4,5-c]pyr...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276042(2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-met...)
Affinity DataIC50: 100nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276043(2-[1-(1-phenylethyl)imidazol-4-yl]-4-(1H-triazol-4...)
Affinity DataIC50: 100nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276044(2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...)
Affinity DataIC50: 100nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276045(2-[1-[2-(2-methoxyphenyl)ethyl]imidazol-4-yl]-4-(1...)
Affinity DataIC50: 100nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276046(2-[1-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)imid...)
Affinity DataIC50: 100nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276047(2-[1-[2-(2-ethoxyphenyl)ethyl]imidazol-4-yl]-4-(1H...)
Affinity DataIC50: 100nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276059(2-[1-[(2,3-dichlorophenyl)methyl]imidazol-4-yl]-4-...)
Affinity DataIC50: 100nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276060(2-[1-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]i...)
Affinity DataIC50: 100nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276061(2-[1-(2-naphthalen-1-ylethyl)imidazol-4-yl]-4-(1H-...)
Affinity DataIC50: 100nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276082(1-benzyl-4-{1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl}...)
Affinity DataIC50: 100nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276083(1-[(2-chlorophenyl)methyl]-4-{1H-[1,2,3]triazolo[4...)
Affinity DataIC50: 100nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276084(1-[(3-chlorophenyl)methyl]-4-{1H-[1,2,3]triazolo[4...)
Affinity DataIC50: 100nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276085(1-[(4-chlorophenyl)methyl]-4-{1H-[1,2,3]triazolo[4...)
Affinity DataIC50: 100nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276086(1-[(3,4-dichlorophenyl)methyl]-4-{1H-[1,2,3]triazo...)
Affinity DataIC50: 100nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276087(1-(4-chlorophenyl)-4-{1H-[1,2,3]triazolo[4,5-c]pyr...)
Affinity DataIC50: 100nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM276088(1-(2-chlorophenyl)-4-{1H-[1,2,3]triazolo[4,5-c]pyr...)
Affinity DataIC50: 100nMAssay Description:PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50498680(CHEMBL3621878)
Affinity DataIC50: 126nMAssay Description:Inhibition of KDM2A (unknown origin) using Biotin-H3(28-48)K36Me2 and H3(28-48)K36Me2 substrates incubated for 30 mins by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50436040(CHEMBL2392184)
Affinity DataIC50: 135nMAssay Description:Competitive binding affinity to recombinant 6xHis-tagged JHDM1A (unknown origin) expressed in Escherichia coli BL21 incubated for 30 mins prior to co...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50324535(CHEMBL1215519 | CHEMBL1229308 | 3-{[9-(Dimethylami...)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDM2A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDM2A (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50495468(CHEMBL3108958)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant FBXL11 (unknown origin) incubated for 15 mins prior to substrate addition by AlphaScreen methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50395083(CHEMBL2164246)
Affinity DataIC50: 250nMAssay Description:Inhibition of human KDM2A expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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