Compile Data Set for Download or QSAR
Report error Found 9051 Enz. Inhib. hit(s) with Target = 'Leucine-rich repeat serine/threonine-protein kinase 2'
LigandPNGBDBM254918(US9675594, 1 | US9499542, 1)
Affinity DataEC50:  201nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254918(US9675594, 1 | US9499542, 1)
Affinity DataEC50:  247nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254919(US9675594, 2 | US9499542, 2)
Affinity DataEC50:  195nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254919(US9675594, 2 | US9499542, 2)
Affinity DataEC50:  170nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254920(US9675594, 3 | US9499542, 3)
Affinity DataEC50:  252nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254920(US9675594, 3 | US9499542, 3)
Affinity DataEC50:  266nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254921(US9675594, 4 | US9499542, 4)
Affinity DataEC50:  851nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254921(US9675594, 4 | US9499542, 4)
Affinity DataEC50:  1.28E+3nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254922(US9675594, 5 | US9499542, 5)
Affinity DataEC50:  1.31E+3nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254922(US9675594, 5 | US9499542, 5)
Affinity DataEC50:  5.44E+3nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254923(US9675594, 6 | US9499542, 6)
Affinity DataEC50:  650nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254923(US9675594, 6 | US9499542, 6)
Affinity DataEC50:  3.87E+3nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254924(US9675594, 7 | US9499542, 7)
Affinity DataEC50:  78nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254924(US9675594, 7 | US9499542, 7)
Affinity DataEC50:  620nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254925(US9675594, 8 | US9499542, 8)
Affinity DataEC50:  288nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254925(US9675594, 8 | US9499542, 8)
Affinity DataEC50:  549nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254926(US9675594, 9 | US9499542, 9)
Affinity DataEC50:  26nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254926(US9675594, 9 | US9499542, 9)
Affinity DataEC50:  149nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254927(US9675594, 10 | US9499542, 10)
Affinity DataEC50:  154nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254927(US9675594, 10 | US9499542, 10)
Affinity DataEC50:  919nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254928(US9675594, 11 | US9499542, 11)
Affinity DataEC50:  240nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254928(US9675594, 11 | US9499542, 11)
Affinity DataEC50:  216nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254929(US9675594, 12 | US9499542, 12)
Affinity DataEC50:  17nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254929(US9675594, 12 | US9499542, 12)
Affinity DataEC50:  15nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254930(US9675594, 13 | US9499542, 13)
Affinity DataEC50:  58nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254930(US9675594, 13 | US9499542, 13)
Affinity DataEC50:  48nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254931(US9675594, 14 | US9499542, 14)
Affinity DataEC50:  2nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254931(US9675594, 14 | US9499542, 14)
Affinity DataEC50:  1nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254932(US9675594, 15 | US9499542, 15)
Affinity DataEC50:  1nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254932(US9675594, 15 | US9499542, 15)
Affinity DataEC50:  4nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254933(US9675594, 16 | US9499542, 16)
Affinity DataEC50:  164nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254933(US9675594, 16 | US9499542, 16)
Affinity DataEC50:  97nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254934(US9675594, 17 | US9499542, 17)
Affinity DataEC50:  527nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254934(US9675594, 17 | US9499542, 17)
Affinity DataEC50:  340nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254935(US9675594, 18 | US9499542, 18)
Affinity DataEC50:  509nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254935(US9675594, 18 | US9499542, 18)
Affinity DataEC50:  358nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254936(US9675594, 19 | US9499542, 19)
Affinity DataEC50:  215nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254936(US9675594, 19 | US9499542, 19)
Affinity DataEC50:  145nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254937(US9675594, 20 | US9499542, 20)
Affinity DataEC50:  50nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254937(US9675594, 20 | US9499542, 20)
Affinity DataEC50:  36nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254938(US9675594, 21 | US9499542, 21)
Affinity DataEC50:  575nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254938(US9675594, 21 | US9499542, 21)
Affinity DataEC50:  393nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254939(US9675594, 22 | US9499542, 22)
Affinity DataEC50:  37nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254939(US9675594, 22 | US9499542, 22)
Affinity DataEC50:  27nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254940(US9675594, 23 | US9499542, 23)
Affinity DataEC50:  108nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254940(US9675594, 23 | US9499542, 23)
Affinity DataEC50:  215nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataKd:  870nMAssay Description:Binding constant for LRRK2 kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50603012(CHEMBL5169734)
Affinity DataEC50:  1.30E+4nMAssay Description:Inhibition of pcDNA5FRT-TO-GFP fused - LRRK2 G2019S mutant (unknown origin) transfected in HEK293 cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50603036(CHEMBL5207998)
Affinity DataEC50:  20nMAssay Description:Inhibition of pcDNA5FRT-TO-GFP fused - LRRK2 G2019S mutant (unknown origin) transfected in HEK293 cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50624631(CHEMBL5423852)
Affinity DataEC50:  920nMAssay Description:Inhibition of LRRK2 G2019S mutant in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
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