Report error Found 117 Enz. Inhib. hit(s) with Target = 'Large neutral amino acids transporter small subunit 1'
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of [14C]-L-leucine uptake at LAT1 in human HT-29 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of [14C]-L-leucine uptake at LAT1 in human HT-29 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 790nMAssay Description:Inhibition of [14C]-L-leucine uptake at LAT1 in human YD-38 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 790nMAssay Description:Inhibition of [14C]-L-leucine uptake at LAT1 in human YD-38 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 980nMAssay Description:Inhibition of recombinant human LAT1More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 3.48E+3nMAssay Description:Induction of LAT1-mediated polyamine efflux in human L3.6PL cells assessed as reduction in cell viability after 48 hrs by MTS assayMore data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of human LAT1 expressed in HEK cells assessed as reduction in uptake of [3H]-gabapentin after 3 mins by scintillation counting based cis-i...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 6.60E+3nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of human LAT1 expressed in HEK cells assessed as reduction in uptake of [3H]-gabapentin after 3 mins by scintillation counting based cis-i...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 7.30E+3nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of human LAT1 expressed in HEK cells assessed as reduction in uptake of [3H]-gabapentin after 3 mins by scintillation counting based cis-i...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 1.04E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 1.70E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 1.82E+4nMAssay Description:Competitive inhibition of [14C]-L-leucine uptake at LAT1 in human MCF7 cells preincubated for 5 mins followed by addition of substrate measured durin...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 1.82E+4nMAssay Description:Competitive inhibition of [14C]-L-leucine uptake at LAT1 in human MCF7 cells preincubated for 5 mins followed by addition of substrate measured durin...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of LAT1 in human MCF7 cells assessed as inhibition of leucine uptakeMore data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 2.77E+4nMAssay Description:Inhibition of LAT1-mediated [14C]-L-leucine uptake in human MCF7 cells after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 2.90E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 3.24E+4nMAssay Description:Inhibition of LAT1-mediated [14C]-L-leucine uptake in human MCF7 cells after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 3.60E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 3.64E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 3.66E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 3.94E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 4.60E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 5.66E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 5.70E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 5.75E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 6.28E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 6.30E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 6.80E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 6.80E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 6.90E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 6.90E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 6.90E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 6.90E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC follo...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 6.90E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC follo...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 7.60E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 7.60E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 8.30E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 8.50E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 8.70E+4nMAssay Description:Inhibition of human LAT1 expressed in HEK293-T-Rex cells assessed as inhibition of [3H]-gabapentin uptake by scintillation counting cis-inhibition as...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 8.91E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 9.20E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 9.50E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 9.60E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 9.62E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of LAT1-mediated [14C]-L-leucine uptake in human MCF7 cells after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
3D Structure (crystal)TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Eastern Finland
Curated by ChEMBL
University of Eastern Finland
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC follo...More data for this Ligand-Target Pair
