Compile Data Set for Download or QSAR
Report error Found 578 Enz. Inhib. hit(s) with Target = 'LIM domain kinase 2'
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50611813(CHEMBL3798651)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of LIMK2 (unknown origin) in presence of ATP at 200 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50611814(CHEMBL3799932)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of LIMK2 (unknown origin) in presence of ATP at 200 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50611815(CHEMBL5269145)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of LIMK2 (unknown origin) in presence of ATP at 200 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50611812(CHEMBL3797519)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of LIMK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50611811(CHEMBL3797874)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of LIMK2 (unknown origin) in presence of ATP at 200 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50611812(CHEMBL3797519)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of LIMK2 (unknown origin) in presence of ATP at 200 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299619((S)-3-(N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299583((S)-N-(3-bromophenyl)-N'-cyano-2-methyl-4-(5-methy...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50117489(CHEMBL3613598)
Affinity DataIC50: 1nMAssay Description:Inhibition of LIMK2 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50117489(CHEMBL3613598)
Affinity DataIC50: 1nMAssay Description:Inhibition of LIMK2 (unknown origin) in presence of ATP at 200 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50117370(CHEMBL3613599)
Affinity DataIC50: 1nMAssay Description:Inhibition of LIMK2 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50117301(CHEMBL3613603)
Affinity DataIC50: 1nMAssay Description:Inhibition of LIMK2 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50117300(CHEMBL3613604)
Affinity DataIC50: 1nMAssay Description:Inhibition of LIMK2 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50044006(CHEMBL3356431)
Affinity DataIC50: 1nMAssay Description:Inhibition of human full-length LIMK2 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50117632(CHEMBL3613609)
Affinity DataIC50: 1nMAssay Description:Inhibition of LIMK2 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50124354(CHEMBL3623439)
Affinity DataIC50: 1nMAssay Description:Inhibition of human N-terminal GST-tagged LIMK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299616((S)-N-(3-tert-butylphenyl)-N'-cyano-2-methyl-4-(5-...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299615((S)-N'-cyano-N-(3-cyanophenyl)-2-methyl-4-(5-methy...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299607((S)-N-(3-bromophenyl)-4-(5-chloro-7H-pyrrolo[2,3-d...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50044086(CHEMBL3356064)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human full-length LIMK2 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human full-length LIMK2 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50117500(CHEMBL3613624)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of LIMK2 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50611810(CHEMBL3799326)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of LIMK2 (unknown origin) in presence of ATP at 200 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50117315(CHEMBL3613600)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of LIMK2 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299584((S)-N-(3-bromo-4-fluorophenyl)-N'-cyano-2-methyl-4...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50117501(CHEMBL3613623)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of LIMK2 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299611((S)-N-(3-chlorophenyl)-N'-cyano-2-methyl-4-(5-meth...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50044004(CHEMBL3356433)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of LIMK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50044004(CHEMBL3356433)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of LIMK2 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299623((S)-N'-cyano-N-(3-(N-isopropylsulfamoyl)phenyl)-2-...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299613((S)-N'-cyano-N-(3-fluorophenyl)-2-methyl-4-(5-meth...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50044012(CHEMBL3356424)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human full-length LIMK2 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299614((S)-N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50117635(CHEMBL3613606)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of LIMK2 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50044010(CHEMBL3356426)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human full-length LIMK2 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50117634(CHEMBL3613607)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of LIMK2 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299612((S)-N-(3-chlorophenyl)-2-methyl-4-(5-methyl-7H-pyr...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50044087(CHEMBL3356063)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human full-length LIMK2 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50044003(CHEMBL3356430)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human full-length LIMK2 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622419(US20230312576, Compound 75)
Affinity DataKi:  2.73nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent

TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50117503(CHEMBL3613621)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of LIMK2 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622485(US20230312576, Compound 198)
Affinity DataKi:  2.89nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent

TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299624((S)-N'-cyano-N-(3-(N-(2-hydroxyethyl)sulfamoyl)phe...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622495(US20230312576, Compound 222)
Affinity DataKi:  2.96nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent

TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299620((S)-N-(3-(2-hydroxyethylcarbamoyl)phenyl)-2-methyl...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50043510(CHEMBL3355507)
Affinity DataIC50: 3nMAssay Description:Inhibition of human full-length LIMK2 expressed in Sf9 cells assessed as incorporation of [33P] from ATP into biotinylated-cofilin substrate in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622419(US20230312576, Compound 75)
Affinity DataKi:  3nMAssay Description:Inhibition of LIMK2 (unknown origin) assessed as inhibition constant by LanthScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
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