Compile Data Set for Download or QSAR
Report error Found 1880 Enz. Inhib. hit(s) with Target = 'Ketohexokinase'
TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769283((5R)-5'-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methy...)
Affinity DataIC50: 0.100nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
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TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769147((S)-5-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyla...)
Affinity DataIC50: 0.100nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769146(5-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methylazeti...)
Affinity DataIC50: 0.100nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769294((3R)-6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl...)
Affinity DataIC50: 0.100nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769276(N-[(3R)-6-[7,7-difluoro-2-[(2S,3R)-3-fluoro-2-meth...)
Affinity DataIC50: 0.100nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769086((5R)-5'-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methy...)
Affinity DataIC50: 0.100nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769095(6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methylazeti...)
Affinity DataIC50: 0.100nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM738719(2-((1R,5S,6R)-3-(5-cyano-6-((S)- 2-methylazetidine...)
Affinity DataIC50: 0.170nMAssay Description:I. Experimental Procedures:1) The compounds were transferred to a 384 reaction plates (PE, 6007290) with Echo (Labcyte, 550);2) After centrifugation,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769271(N-[6-[7,7-difluoro-2-[(2S,3R)-3-fluoro-2-methyl-az...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769290(6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl-azet...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769416(6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl-azet...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769084((S)-5'-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyl...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769126(N-((R)-6-(7,7-difluoro-2-((S)-2-methylazetidin-1-y...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769081((R)-6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyla...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769286(6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl-azet...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769097((S)-6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyla...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769074((S)-5-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyla...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769427((R)-6-(7,7-difluoro-2-((R)-2-(trifluoromethyl)azet...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769299((3S)-6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769157((3S)-6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyl...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769282((5R)-5'-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methy...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769156(6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methylazeti...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769297(6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl-azet...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769394(3-amino-3-(4-(7,7-difluoro-2-((2S,3R)-3-fluoro-2-m...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769273((5S)-5'-[7,7-difluoro-2-[(2R)-2-(fluoromethyl)azet...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769296(6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl-azet...)
Affinity DataIC50: 0.300nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769423((S)-6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyla...)
Affinity DataIC50: 0.300nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769287(6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methylazeti...)
Affinity DataIC50: 0.300nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769235((S)-5-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyla...)
Affinity DataIC50: 0.300nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769079(6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methylazeti...)
Affinity DataIC50: 0.300nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769272(N-[6-[7,7-difluoro-2-[(2S,3R)-3-fluoro-2-methyl-az...)
Affinity DataIC50: 0.300nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM738731(Preparation of 2-((1R,5S,6R)-3-(5-cyano-6-((S)-2-m...)
Affinity DataIC50: 0.390nMAssay Description:I. Experimental Procedures:1) The compounds were transferred to a 384 reaction plates (PE, 6007290) with Echo (Labcyte, 550);2) After centrifugation,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769185(3-[4-[7,7-difluoro-2-[(2R)-2-(trifluoromethyl)azet...)
Affinity DataIC50: 0.400nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769291(6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl-azet...)
Affinity DataIC50: 0.400nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769399((R)-3-amino-3-(4-(7,7-difluoro-2-(2-(trifluorometh...)
Affinity DataIC50: 0.400nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769300(6-[7,7-difluoro-2-[(2R)-2-(trifluoromethyl)azetidi...)
Affinity DataIC50: 0.400nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769075(N-(6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methylaz...)
Affinity DataIC50: 0.400nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM738730(Preparation of 2-((1R,5S,6R)-3-(5-cyano-6-((S)-2-m...)
Affinity DataIC50: 0.440nMAssay Description:I. Experimental Procedures:1) The compounds were transferred to a 384 reaction plates (PE, 6007290) with Echo (Labcyte, 550);2) After centrifugation,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769229(N-((S)-5-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-meth...)
Affinity DataIC50: 0.5nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769278(N-[(3R)-6-[2-[(2S)-3,3-difluoro-2-methyl-azetidin-...)
Affinity DataIC50: 0.5nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769400(3-amino-3-(4-(7,7-difluoro-2-((R)-2-(trifluorometh...)
Affinity DataIC50: 0.5nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769355(N-[6-[7,7-difluoro-2-[(2S)-2-methylazetidin-1-yl]-...)
Affinity DataIC50: 0.5nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM50628740(CHEMBL5402865 | US12410160, Example 696)
Affinity DataIC50: 0.5nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769064(N-((R)-6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-meth...)
Affinity DataIC50: 0.5nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769233(5-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methylazeti...)
Affinity DataIC50: 0.5nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769292(6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl-azet...)
Affinity DataIC50: 0.5nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM50628740(CHEMBL5402865 | US12410160, Example 696)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KHK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM749704(acid | US12331038, Compound 2)
Affinity DataIC50: 0.520nMAssay Description:1) The present compounds and the control drug were formulated in DMSO to 10 mM as stock solutions for test.2) The stock solutions of the compounds of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/9/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM50648642(CHEMBL5611924)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant His tagged human KHK-C incubated for 60 mins in presence of ATP by ADP-GloTM kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769175(N-((R)-6-(7,7-difluoro-2-((R)-2-(trifluoromethyl)a...)
Affinity DataIC50: 0.600nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/17/2025
Entry Details
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