Compile Data Set for Download or QSAR
Report error Found 174 Enz. Inhib. hit(s) with Target = 'Isoleucine--tRNA ligase'
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50471296(CHEMBL87935)
Affinity DataIC50: 0.700nMAssay Description:Inhibition concentration against Isoleucyl-tRNA synthetase from Staphylococcus aureus NCTC 6571More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50290686(9-(4-((2S,3R,4R,5S)-3,4-dihydroxy-5-(((2S,3S)-3-((...)
Affinity DataIC50: 0.800nMAssay Description:Compound was evaluated for inhibitory activity against Isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article

TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50290686(9-(4-((2S,3R,4R,5S)-3,4-dihydroxy-5-(((2S,3S)-3-((...)
Affinity DataIC50: 0.850nMAssay Description:Inhibition concentration against Isoleucyl-tRNA synthetase from Staphylococcus aureus NCTC 6571More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50471292(CHEMBL315230)
Affinity DataIC50: 1.10nMAssay Description:Inhibition concentration against Isoleucyl-tRNA synthetase from Staphylococcus aureus NCTC 6571More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50471294(CHEMBL276855)
Affinity DataIC50: 1.90nMAssay Description:Inhibition concentration against Isoleucyl-tRNA synthetase from Staphylococcus aureus NCTC 6571More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50471297(CHEMBL424608)
Affinity DataIC50: 2.10nMAssay Description:Inhibition concentration against Isoleucyl-tRNA synthetase from Staphylococcus aureus NCTC 6571More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50471293(CHEMBL83449)
Affinity DataIC50: 3.60nMAssay Description:Inhibition concentration against Isoleucyl-tRNA synthetase from Staphylococcus aureus NCTC 6571More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50470911(CHEMBL122825)
Affinity DataIC50: 4.45nMAssay Description:Inhibitory activity against isoleucyl-tRNA synthetase (IRS) of Staphylococcus aureusMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217841(REVEROMYCIN A)
Affinity DataIC50: 4.46nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50471295(CHEMBL312853)
Affinity DataIC50: 5.30nMAssay Description:Inhibition concentration against Isoleucyl-tRNA synthetase from Staphylococcus aureus NCTC 6571More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50471291(CHEMBL83394)
Affinity DataIC50: 6nMAssay Description:Inhibition concentration against isoleucyl tRNA synthetase from Staphylococcus aureus NCTC 6571More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50470914(CHEMBL120343)
Affinity DataIC50: 6.67nMAssay Description:Inhibitory activity against isoleucyl-tRNA synthetase (IRS) of Staphylococcus aureus NCTC 3571More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Escherichia coli (strain K12))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50524451(CHEMBL4553017)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of recombinant Escherichia coli BL21(DE3) isoleucyl-tRNA synthetase expressed in Escherichia coli Rosetta 2 (DE3) assessed as reduction in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50470913(CHEMBL120798)
Affinity DataIC50: 6.87nMAssay Description:Inhibitory activity against isoleucyl-tRNA synthetase (IRS) of Staphylococcus aureusMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50470912(CHEMBL120437)
Affinity DataIC50: 7.98nMAssay Description:Inhibitory activity against isoleucyl-tRNA synthetase (IRS) of Staphylococcus aureusMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093003((4aR,6S,7R,7aS)-7-[2-((2S,3S)-2-Amino-3-methyl-pen...)
Affinity DataIC50: 14nMAssay Description:Compound was evaluated for its inhibitory activity against Isoleucyl-tRNA synthetase from staphylococcus aureus WCUH29More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50366870(CHEMBL605376)
Affinity DataIC50: 14nMAssay Description:Inhibitory activity against Escherichia coli Isoleucyl-tRNA synthetase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Trypanosoma brucei brucei (strain 927/4 GUTat10.1))
University of Washington

LigandPNGBDBM188488(NSC70422)
Affinity DataIC50: 14.1nMAssay Description:Compound stocks were prepared at a 10 mM concentration in dimethyl sulfoxide.T. brucei bloodstream forms (100 µl at 2.0 × 10^4 parasites/ml) were pla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50075058(((S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 15nMAssay Description:Inhibition of Escherichia coli isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50479281(2,3-DIHYDROREVEROMYCIN A)
Affinity DataIC50: 17.5nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50075061(((S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Escherichia coli isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50479274(4-HYDROXY REVEROMYCIN A)
Affinity DataIC50: 21.7nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50075056(((S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 30nMAssay Description:Inhibition of Escherichia coli isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50075059(((S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 30nMAssay Description:Inhibition of Escherichia coli isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50075058(((S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 34nMAssay Description:Compound tested for the inhibition of human isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50479284(CHEMBL442945)
Affinity DataIC50: 36.9nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093001((4aR,6S,7R,7aS)-7-[2-((S)-2-Amino-3-methyl-butyryl...)
Affinity DataIC50: 37nMAssay Description:Compound was evaluated for its inhibitory activity against Isoleucyl-tRNA synthetase from staphylococcus aureus WCUH29More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50366862(CHEMBL605592)
Affinity DataIC50: 39nMAssay Description:Inhibitory activity against Escherichia coli Isoleucyl-tRNA synthetase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075056(((S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 40nMAssay Description:Compound tested for the inhibition of Staphylococcus aureus isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50075056(((S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 40nMAssay Description:Compound tested for the inhibition of Staphylococcus aureus isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50075070(((S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 45nMAssay Description:Inhibition of Escherichia coli isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075058(((S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 50nMAssay Description:Compound tested for the inhibition of Staphylococcus aureus isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075067(((S)-2-Amino-4-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 54nMAssay Description:Compound tested for the inhibition of Staphylococcus aureus Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093004((4aR,6S,7R,7aS)-7-[2-((2S,3S)-2-Amino-3-methyl-pen...)
Affinity DataIC50: 60nMAssay Description:Compound was evaluated for its inhibitory activity against Isoleucyl-tRNA synthetase from staphylococcus aureus WCUH29More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50479277(2,3-DIHYDRO-5-EPIREVEROMYCIN A)
Affinity DataIC50: 88nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075069(((S)-2-Amino-4-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 90nMAssay Description:Compound tested for the inhibition of Staphylococcus aureus Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50222902(CHEMBL1163069)
Affinity DataIC50: 98nMAssay Description:Inhibitory activity against Escherichia coli Isoleucyl-tRNA synthetase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075063(((S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 100nMAssay Description:Compound tested for the inhibition of Staphylococcus aureus isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50075063(((S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Escherichia coli isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075055(((S)-2-Amino-4-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 100nMAssay Description:Compound tested for the inhibition of Staphylococcus aureus Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50290689(9-{(E)-4-[(2S,3R,4R,5S)-5-(3-Chloro-propane-1-sulf...)
Affinity DataIC50: 100nMAssay Description:Compound was evaluated for inhibitory activity against Isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50075068(((2S,3S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Escherichia coli isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217935(CHEMBL114859)
Affinity DataIC50: 100nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50075065(((S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 110nMAssay Description:Inhibition of Escherichia coli isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093002((4aR,6S,7R,7aS)-7-[2-((2S,3S)-2-Amino-3-methyl-pen...)
Affinity DataIC50: 120nMAssay Description:Compound was evaluated for its inhibitory activity against Isoleucyl-tRNA synthetase from staphylococcus aureus WCUH29More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075065(((S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 120nMAssay Description:Compound tested for the inhibition of Staphylococcus aureus isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50075062(((S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 120nMAssay Description:Inhibition of Escherichia coli isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Staphylococcus aureus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075061(((S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: 130nMAssay Description:Compound tested for the inhibition of Staphylococcus aureus isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217844(CHEMBL115953)
Affinity DataIC50: 168nMAssay Description:Inhibition of IleRSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoleucine--tRNA ligase(Escherichia coli (strain K12))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50227798(CHEMBL42269)
Affinity DataIC50: 191nMAssay Description:Inhibitory activity against Isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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