Compile Data Set for Download or QSAR
Report error Found 101 Enz. Inhib. hit(s) with Target = 'Isoform A of Ketohexokinase (Peripheral)'
LigandPNGBDBM707376((2S,3R)-1-{5-chloro-4-[1-(1- methyl-3-azetidinyl)-...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707376((2S,3R)-1-{5-chloro-4-[1-(1- methyl-3-azetidinyl)-...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707377((2S,3R)-1-{5-ethyl-4-[1-(1- methyl-3-azetidinyl)-4...)
Affinity DataIC50: 0.960nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707370(2-(4-{2-[(S)-2-methyl-1- azetidinyl]-5-chloro-6- (...)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707378((2S,3R)-2-methyl-1-{5-methyl-4- [1-(1-methyl-3-aze...)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707387((2S,3R)-1-{6-(difluoromethyl)-5- methyl-4-[1-(1-me...)
Affinity DataIC50: 1.46nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM518444(US11124500, Example 35 | (2S,3R)-2-Methyl-1-[4-[1-...)
Affinity DataIC50: 1.59nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM707370(2-(4-{2-[(S)-2-methyl-1- azetidinyl]-5-chloro-6- (...)
Affinity DataIC50: 1.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM707401((2S,3R)-1-{4-[1-(3-azetidinyl)-4- pyrazolyl]-6-(di...)
Affinity DataIC50: 1.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM707387((2S,3R)-1-{6-(difluoromethyl)-5- methyl-4-[1-(1-me...)
Affinity DataIC50: 2.05nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707367(2-(4-{2-[(R)-2-(trifluoromethyl)-1- azetidinyl]-5-...)
Affinity DataIC50: 2.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM707391((2R,3R)-1-{4-[1-(1-methyl-3- azetidinyl)-4-pyrazol...)
Affinity DataIC50: 2.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707372(2-(4-{2-[(S)-2-methyl-1- azetidinyl]-5-ethyl-6- (t...)
Affinity DataIC50: 2.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707369(2-(4-{2-[(S)-2-methyl-1- azetidinyl]-5-methyl-6- (...)
Affinity DataIC50: 2.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM518415(US11124500, Example 9 | 6-[1-[1-(2-Hydroxyethyl)-4...)
Affinity DataIC50: 3.58nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM518442(US11124500, Example 33 | 4-[1-(Azetidin-3-yl)pyraz...)
Affinity DataIC50: 3.63nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM518418(US11124500, Example 12 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 3.65nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM518445(US11124500, Example 36 | [(2R)-1-[4-[1-(1-Methylaz...)
Affinity DataIC50: 3.98nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM707378((2S,3R)-2-methyl-1-{5-methyl-4- [1-(1-methyl-3-aze...)
Affinity DataIC50: 4.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707384(2-(4-{2-[(R)-2-(trifluoromethyl)-1- azetidinyl]-6-...)
Affinity DataIC50: 4.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707394(2-(4-{2-[(R)-2-(trifluoromethyl)-1- azetidinyl]-5-...)
Affinity DataIC50: 4.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707401((2S,3R)-1-{4-[1-(3-azetidinyl)-4- pyrazolyl]-6-(di...)
Affinity DataIC50: 4.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM707409(2-(4-{2-[(R)-2-(difluoromethyl)-1- azetidinyl]-5-m...)
Affinity DataIC50: 4.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM707369(2-(4-{2-[(S)-2-methyl-1- azetidinyl]-5-methyl-6- (...)
Affinity DataIC50: 4.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM518435(US11124500, Example 27 | 6-[1-(3-Hydroxy-4-piperid...)
Affinity DataIC50: 4.63nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707390(2-(4-{2-[(S)-2-methyl-1- azetidinyl]-6-(difluorome...)
Affinity DataIC50: 5.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707392(2-(4-{2-[(S)-2-methyl-1- azetidinyl]-6-(difluorome...)
Affinity DataIC50: 5.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM518417(US11124500, Example 11 | 6-[1-(2-Hydroxyethyl)pyra...)
Affinity DataIC50: 5.23nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM707384(2-(4-{2-[(R)-2-(trifluoromethyl)-1- azetidinyl]-6-...)
Affinity DataIC50: 5.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM518443(US11124500, Example 34 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 5.41nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707374((2S,3R)-1-{5-methoxy-4-[1-(1- methyl-3-azetidinyl)...)
Affinity DataIC50: 5.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707391((2R,3R)-1-{4-[1-(1-methyl-3- azetidinyl)-4-pyrazol...)
Affinity DataIC50: 5.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM707367(2-(4-{2-[(R)-2-(trifluoromethyl)-1- azetidinyl]-5-...)
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM518413(US11124500, Example 7 | 2-[(2S,3R)-3-Hydroxy-2-met...)
Affinity DataIC50: 6.02nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM707404(2-(4-{2-[(R)-2-(difluoromethyl)-1- azetidinyl]-5-c...)
Affinity DataIC50: 6.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707385((2S,3R)-1-{6-(difluoromethyl)-5- methoxy-4-[1-(1-m...)
Affinity DataIC50: 6.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM518432(US11124500, Example 24b)
Affinity DataIC50: 6.75nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707409(2-(4-{2-[(R)-2-(difluoromethyl)-1- azetidinyl]-5-m...)
Affinity DataIC50: 6.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM518430(US11124500, Example 24 | 6-[1-(2,3-Dihydroxypropyl...)
Affinity DataIC50: 7.29nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)
Affinity DataIC50: 7.30nMAssay Description:Assay D, was performed using human KHK-A to assess the potency of compounds in inhibiting activity of this enzyme. Compounds were prepared in DMSO as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)
Affinity DataIC50: 7.30nMAssay Description:Assay D, was performed using human KHK-A to assess the potency of compounds in inhibiting activity of this enzyme. Compounds were prepared in DMSO as...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707404(2-(4-{2-[(R)-2-(difluoromethyl)-1- azetidinyl]-5-c...)
Affinity DataIC50: 7.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM518419(US11124500, Example 13 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 7.69nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM707374((2S,3R)-1-{5-methoxy-4-[1-(1- methyl-3-azetidinyl)...)
Affinity DataIC50: 7.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707398(2-(4-{2-[(S)-2-methyl-1- azetidinyl]-5-fluoro-6- (...)
Affinity DataIC50: 8.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM707377((2S,3R)-1-{5-ethyl-4-[1-(1- methyl-3-azetidinyl)-4...)
Affinity DataIC50: 8.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM707372(2-(4-{2-[(S)-2-methyl-1- azetidinyl]-5-ethyl-6- (t...)
Affinity DataIC50: 8.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707368(2-(4-{2-[(R)-2-(trifluoromethyl)-1- azetidinyl]-6-...)
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM518431(US11124500, Example 24a)
Affinity DataIC50: 9.99nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))TBA
LigandPNGBDBM707375((2S,3R)-1-{6-(difluoromethyl)-4- [1-(1-methyl-3-az...)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

Displayed 1 to 50 (of 101 total ) | Next | Last >>
Jump to: