Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with Target = 'Isocitrate dehydrogenase [NADP] cytoplasmic/ mitochondrial'
TargetIsocitrate dehydrogenase [NADP] cytoplasmic/ mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM363585(US9850277, Compound 77 | US10689414, Compound 77 |...)
Affinity DataIC50: 100nMAssay Description:Inhibition of IDH1/2 in human U87-MG cells assessed as suppression of 2-HG production incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic/ mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM363545(US9850277, Compound 37 | US9850277, Compound 64 | ...)
Affinity DataIC50: 100nMAssay Description:Inhibition of IDH1/2 in human U87-MG cells assessed as suppression of 2-HG production incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic/ mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM363580(US9850277, Compound 72 | US10689414, Compound 72 |...)
Affinity DataIC50: 100nMAssay Description:Inhibition of IDH1/2 in human U87-MG cells assessed as suppression of 2-HG production incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic/ mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50503259(CHEMBL4591331)
Affinity DataIC50: 100nMAssay Description:Inhibition of IDH1/2 in human U87-MG cells assessed as suppression of 2-HG production incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic/ mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM363576(US9850277, Compound 68 | US10689414, Compound 68 |...)
Affinity DataIC50: 100nMAssay Description:Inhibition of IDH1/2 in human U87-MG cells assessed as suppression of 2-HG production incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic/ mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50400272(CHEMBL2180727)
Affinity DataIC50: 250nMAssay Description:Inhibition of IDH1/2 in human U87-MG cells assessed as suppression of 2-HG production incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed